KEGG   PATHWAY: cjc04020
Entry
cjc04020                    Pathway                                
Name
Calcium signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
cjc04020  Calcium signaling pathway
cjc04020

Other DBs
GO: 0019722
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385008  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100385029  LHCGR; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
100385253  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
100385383  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100385658  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100385763  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100385862  FGF20; fibroblast growth factor 20 [KO:K04358]
100385966  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100386041  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100386343  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100386369  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
100386452  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100386514  PLN; cardiac phospholamban [KO:K05852]
100386665  CASQ2; calsequestrin-2 [KO:K23445]
100386734  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
100386819  CALM2; calmodulin-2 isoform X2 [KO:K02183]
100386921  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100386978  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100387000  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
100387059  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100387454  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
100387477  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
100387535  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
100387664  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100387695  FGF10; fibroblast growth factor 10 [KO:K04358]
100387720  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
100387937  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100388148  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100388195  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X4 [KO:K05211]
100388327  ADORA2B; adenosine receptor A2b [KO:K04267]
100388404  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100388410  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
100388537  TRDN; triadin isoform X4 [KO:K23449]
100388550  FGF16; fibroblast growth factor 16 [KO:K04358]
100388587  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2 [KO:K13755] [EC:3.1.4.17]
100388628  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100388651  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100388984  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100389629  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100389852  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100389889  FGF21; fibroblast growth factor 21 [KO:K22429]
100389992  TBXA2R; thromboxane A2 receptor isoform X2 [KO:K04264]
100390112  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100390180  CALM1; calmodulin-1 [KO:K02183]
100390192  FGFR1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100390347  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100390442  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100390531  FGF6; fibroblast growth factor 6 [KO:K04358]
100390599  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100390843  [KO:K04960]
100390938  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100391162  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100391332  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100391424  [KO:K04515] [EC:2.7.11.17]
100391801  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100391837  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100392014  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100392123  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100392161  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
100392199  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100392537  ITPKC; inositol-trisphosphate 3-kinase C isoform X2 [KO:K00911] [EC:2.7.1.127]
100392653  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100392656  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100392707  FGF23; fibroblast growth factor 23 [KO:K22428]
100392792  FGF9; fibroblast growth factor 9 [KO:K04358]
100392986  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100393010  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100393329  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
100393510  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
100393573  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
100393973  TACR3; neuromedin-K receptor [KO:K04224]
100394234  NTSR1; neurotensin receptor type 1 [KO:K04211]
100394265  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100394497  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100394728  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
100394752  HTR6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
100395031  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
100395085  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
100395294  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100395554  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
100395618  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100395759  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
100395984  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100396053  PTAFR; platelet-activating factor receptor [KO:K04279]
100396102  TACR1; substance-P receptor [KO:K04222]
100396206  AVPR1A; vasopressin V1a receptor [KO:K04226]
100396232  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100396387  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100396434  P2RX4; P2X purinoceptor 4 [KO:K05218]
100396690  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100396705  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
100396892  PHKA1; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
100396964  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
100397220  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100397253  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
100397413  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
100397497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100397583  HRH2; histamine H2 receptor [KO:K04150]
100397824  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
100397860  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
100397905  RYR3; ryanodine receptor 3 isoform X6 [KO:K04963]
100397940  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
100397956  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515] [EC:2.7.11.17]
100398033  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100398162  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100398261  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
100398535  DRD1; D(1A) dopamine receptor [KO:K04144]
100398595  [KO:K04358]
100399376  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
100399481  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100399591  BDKRB2; B2 bradykinin receptor [KO:K03916]
100399716  STIM1; stromal interaction molecule 1 isoform X2 [KO:K16059]
100399873  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
100400074  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100400081  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100400126  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X2 [KO:K08794] [EC:2.7.11.17]
100400167  [KO:K04161]
100400356  F2R; proteinase-activated receptor 1 [KO:K03914]
100400563  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
100400613  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100400670  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100400737  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100400803  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100401180  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
100401190  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
100401418  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100401632  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
100401797  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100401859  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
100402086  STIM2; stromal interaction molecule 2 isoform X3 [KO:K18196]
100402660  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100402888  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100402965  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100403006  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
100403192  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
100403194  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X4 [KO:K05850] [EC:7.2.2.10]
100403358  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100403390  CCKAR; cholecystokinin receptor type A [KO:K04194]
100403424  [KO:K05863]
100403503  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X7 [KO:K00476] [EC:1.14.11.16]
100403515  CASQ1; calsequestrin-1 [KO:K23468]
100403596  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
100403811  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100404098  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
100404136  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
100404210  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
100404308  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100404341  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100404378  TFEB; transcription factor EB isoform X1 [KO:K15590]
100404440  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100404484  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100404537  [KO:K05863]
100404620  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100404812  TPCN2; two pore channel protein 2 isoform X2 [KO:K14077]
100405019  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
100405187  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100405403  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100405490  [KO:K05863]
100405844  [KO:K05863]
100405886  FGF7; fibroblast growth factor 7 [KO:K04358]
100405903  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100405957  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
100406081  CALM3; calmodulin-3 [KO:K02183]
100406252  P2RX2; LOW QUALITY PROTEIN: P2X purinoceptor 2 [KO:K05216]
100406276  ADRA1A; alpha-1A adrenergic receptor isoform X2 [KO:K04135]
100406295  OXTR; oxytocin receptor [KO:K04229]
100406419  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100406548  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100406587  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100406733  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
100406735  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X36 [KO:K04850]
100406801  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100406916  RYR2; ryanodine receptor 2 isoform X7 [KO:K04962]
100406954  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100407045  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100407472  BDKRB1; B1 bradykinin receptor [KO:K03915]
100407692  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100407701  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
100407908  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100408115  [KO:K04345] [EC:2.7.11.11]
100408128  DRD5; D(1B) dopamine receptor [KO:K05840]
100408289  CALML3; calmodulin-like protein 3 [KO:K02183]
100408515  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
100408539  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
100408551  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100408572  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
100408597  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
100408935  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X6 [KO:K04855]
100408980  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100409044  [KO:K10784]
100409206  [KO:K04345] [EC:2.7.11.11]
100409380  [KO:K05863]
100409440  MYLK; myosin light chain kinase, smooth muscle isoform X3 [KO:K00907] [EC:2.7.11.18]
100409540  FGF4; fibroblast growth factor 4 [KO:K04358]
100409716  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100409758  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100409938  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100409940  [KO:K26467]
100410075  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100410253  FGF3; fibroblast growth factor 3 [KO:K04358]
100410292  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
100410312  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100410352  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4 [KO:K04515] [EC:2.7.11.17]
100410901  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100411083  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
100411164  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
100411168  P2RX5; P2X purinoceptor 5 isoform X2 [KO:K05219]
100411371  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100411479  ORAI2; protein orai-2 isoform X1 [KO:K16057]
100411569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
100411629  TNNC2; troponin C, skeletal muscle [KO:K12042]
100411714  HRH1; histamine H1 receptor [KO:K04149]
100411879  GRPR; gastrin-releasing peptide receptor [KO:K04169]
100412022  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
100412081  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100412198  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
100412331  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100412379  MCOLN3; mucolipin-3 isoform X3 [KO:K04994]
100412528  TACR2; substance-K receptor isoform X1 [KO:K04223]
100412630  SLC8A3; sodium/calcium exchanger 3 isoform X4 [KO:K05849]
100412645  EDNRB; endothelin receptor type B [KO:K04198]
100412760  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
100412906  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
100413191  NTRK3; NT-3 growth factor receptor isoform X5 [KO:K05101] [EC:2.7.10.1]
100413506  HTR4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
100413680  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100413758  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100413857  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100414073  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
100414106  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
100414185  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
100414246  AVPR1B; vasopressin V1b receptor [KO:K04227]
100414268  P2RX1; P2X purinoceptor 1 [KO:K05215]
100414296  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2 [KO:K13755] [EC:3.1.4.17]
100414348  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100414371  FGF22; fibroblast growth factor 22 isoform X3 [KO:K04358]
100414478  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
100414522  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5 [KO:K13755] [EC:3.1.4.17]
100414635  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
100414671  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
100414856  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100415104  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X10 [KO:K04854]
100415141  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100415165  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100415252  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100415275  ORAI3; protein orai-3 [KO:K16058]
100895717  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100896470  [KO:K10785]
100896987  [KO:K10785]
103787209  [KO:K04632]
103789024  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103791887  C3H4orf3; uncharacterized protein C4orf3 homolog isoform X3 [KO:K26467]
103793381  SMIM6; small integral membrane protein 6 [KO:K26468]
103793556  [KO:K06856]
103796001  SLN; sarcolipin [KO:K22642]
103796730  MRLN; myoregulin [KO:K22643]
108588103  [KO:K05863]
108590441  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
108592443  CALML5; calmodulin-like protein 5 [KO:K02183]
118144170  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118148021  [KO:K02183]
118151333  [KO:K04345] [EC:2.7.11.11]
118152209  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
128929061  FGF19; fibroblast growth factor 19 [KO:K22603]
128930731  [KO:K05863]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
cjc04010  MAPK signaling pathway
cjc04070  Phosphatidylinositol signaling system
cjc04210  Apoptosis
cjc04720  Long-term potentiation
cjc04730  Long-term depression
KO pathway
ko04020   

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