KEGG   PATHWAY: cpic04146
Entry
cpic04146                   Pathway                                
Name
Peroxisome - Chrysemys picta (western painted turtle)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
cpic04146  Peroxisome
cpic04146

Other DBs
GO: 0005777
Organism
Chrysemys picta (western painted turtle) [GN:cpic]
Gene
101953542  PEX16; peroxisomal biogenesis factor 16 [KO:K13335]
101936933  PEX3; peroxisomal biogenesis factor 3 [KO:K13336]
103306240  PEX19; peroxisomal biogenesis factor 19 isoform X1 [KO:K13337]
101943980  ABCD3; ATP-binding cassette sub-family D member 3 isoform X1 [KO:K05677] [EC:7.6.2.4]
101936958  PEX1; peroxisome biogenesis factor 1 isoform X1 [KO:K13338]
101947860  PEX6; peroxisome biogenesis factor 6 [KO:K13339]
101937979  PEX26; peroxisome assembly protein 26 isoform X1 [KO:K13340]
101944222  PEX7; peroxisomal biogenesis factor 7 [KO:K13341]
101946664  PEX5; peroxisomal biogenesis factor 5 isoform X3 [KO:K13342]
101938425  PEX5L; PEX5-related protein [KO:K13342]
101951782  PEX14; peroxisomal membrane protein PEX14 [KO:K13343]
101951170  PEX13; peroxisome biogenesis factor 13 [KO:K13344]
101937393  PEX12; peroxisome assembly protein 12 [KO:K13345]
101954183  PEX10; peroxisome biogenesis factor 10 isoform X1 [KO:K13346]
101946156  PEX2; peroxisome biogenesis factor 2 [KO:K06664]
101953343  PXMP2; peroxisomal membrane protein 2 [KO:K13347]
101945128  MPV17L2; mpv17-like protein 2 [KO:K13348]
101931987  MPV17; protein Mpv17 [KO:K13348]
101950731  MPV17L; mpv17-like protein isoform X2 [KO:K13349]
101953719  PXMP4; peroxisomal membrane protein 4 [KO:K13350]
101934152  PEX11A; peroxisomal membrane protein 11A [KO:K13351]
101940022  PEX11B; peroxisomal membrane protein 11B isoform X1 [KO:K13352]
101934537  SLC25A17; peroxisomal membrane protein PMP34 isoform X1 [KO:K13354]
101939557  HACL1; 2-hydroxyacyl-CoA lyase 1 [KO:K12261] [EC:4.1.2.63]
101934712  AMACR; alpha-methylacyl-CoA racemase [KO:K01796] [EC:5.1.99.4]
101936756  PHYH; phytanoyl-CoA dioxygenase, peroxisomal [KO:K00477] [EC:1.14.11.18]
101934853  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
101943673  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X2 [KO:K00232] [EC:1.3.3.6]
101950611  ACOX2; peroxisomal acyl-coenzyme A oxidase 2 isoform X1 [KO:K10214] [EC:1.17.99.3]
101945395  HSD17B4; peroxisomal multifunctional enzyme type 2 isoform X2 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
101937963  SCP2; sterol carrier protein 2 isoform X2 [KO:K08764] [EC:2.3.1.176]
101932563  acyl-coenzyme A amino acid N-acyltransferase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
101938826  BAAT; bile acid-CoA:amino acid N-acyltransferase [KO:K00659] [EC:2.3.1.65 3.1.2.2]
101941626  EHHADH; peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
101943221  ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal isoform X1 [KO:K07513] [EC:2.3.1.16]
101947023  DECR2; peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X2 [KO:K13237] [EC:1.3.1.124]
101938914  ECH1; delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial [KO:K12663] [EC:5.3.3.21]
101943317  ATP-binding cassette sub-family D member 1 [KO:K05675] [EC:7.6.2.4]
101947557  ABCD2; ATP-binding cassette sub-family D member 2 [KO:K05676] [EC:7.6.2.4]
101953341  ABCD4; lysosomal cobalamin transporter ABCD4 isoform X3 [KO:K05678] [EC:7.6.2.8]
101944975  SLC27A5; bile acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
101938413  SLC27A2; very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
101942555  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X2 [KO:K01897] [EC:6.2.1.3]
101950016  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
101942204  ACSL5; LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
101949613  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X4 [KO:K01897] [EC:6.2.1.3]
101947978  ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:6.2.1.3]
101933632  PECR; peroxisomal trans-2-enoyl-CoA reductase [KO:K07753] [EC:1.3.1.38]
101939042  ECI2; enoyl-CoA delta isomerase 2 isoform X1 [KO:K13239] [EC:5.3.3.8]
101934147  NUDT7; peroxisomal coenzyme A diphosphatase NUDT7 isoform X1 [KO:K17879] [EC:3.6.1.77]
101948071  NUDT12; NAD-capped RNA hydrolase NUDT12 isoform X3 [KO:K03426] [EC:3.6.1.22]
101945950  NUDT13; NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X1 [KO:K03426] [EC:3.6.1.22]
101948184  NUDT19; LOW QUALITY PROTEIN: nucleoside diphosphate-linked moiety X motif 19 [KO:K13355] [EC:3.6.1.77]
101938495  ACOT8; acyl-coenzyme A thioesterase 8 [KO:K11992] [EC:3.1.2.27]
101944462  CRAT; carnitine O-acetyltransferase isoform X1 [KO:K00624] [EC:2.3.1.7]
101949514  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
101942862  CROT; peroxisomal carnitine O-octanoyltransferase [KO:K05940] [EC:2.3.1.137]
101954180  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
101948121  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
101952600  AGPS; alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1 [KO:K00803] [EC:2.5.1.26]
101934674  FAR2; fatty acyl-CoA reductase 2 isoform X1 [KO:K13356] [EC:1.2.1.84]
101931748  FAR1; fatty acyl-CoA reductase 1 isoform X3 [KO:K13356] [EC:1.2.1.84]
101939185  MVK; mevalonate kinase [KO:K00869] [EC:2.7.1.36]
101930857  PMVK; phosphomevalonate kinase [KO:K13273] [EC:2.7.4.2]
101942906  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
101943950  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
101933580  DDO; D-aspartate oxidase isoform X2 [KO:K00272] [EC:1.4.3.1]
101940863  IDH1; isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
101934619  IDH2; isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
101935511  PAOX; peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X1 [KO:K00308] [EC:1.5.3.13]
101941340  PIPOX; LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101939287  HMGCL; hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1 [KO:K01640] [EC:4.1.3.4]
101931589  HMGCLL1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X1 [KO:K01640] [EC:4.1.3.4]
101946672  HAO2; hydroxyacid oxidase 2 isoform X1 [KO:K11517] [EC:1.1.3.15]
101933199  HAO1; hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
101937020  CAT; catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
101937951  PRDX5; peroxiredoxin-5, mitochondrial [KO:K11187] [EC:1.11.1.24]
101937246  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101954175  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
101941684  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101951902  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
101948727  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101946179  GSTK1; glutathione S-transferase kappa 1 isoform X1 [KO:K13299] [EC:2.5.1.18]
101953114  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101953306  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
cpic00071  Fatty acid degradation
cpic00120  Primary bile acid biosynthesis
cpic00230  Purine metabolism
cpic00564  Glycerophospholipid metabolism
cpic00565  Ether lipid metabolism
cpic00830  Retinol metabolism
cpic00900  Terpenoid backbone biosynthesis
cpic03320  PPAR signaling pathway
KO pathway
ko04146   
LinkDB

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