KEGG   PATHWAY: daz03040
Entry
daz03040                    Pathway                                
Name
Spliceosome - Drosophila arizonae
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
daz03040  Spliceosome
daz03040

Other DBs
GO: 0005681
Organism
Drosophila arizonae [GN:daz]
Gene
108618261  probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
108611823  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
108611695  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
108619452  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
108613566  pre-mRNA-processing factor 17 [KO:K12816]
108612370  pre-mRNA-splicing factor 18 [KO:K12817]
108616142  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
108620734  pre-mRNA-splicing factor Slu7 [KO:K12819]
108617391  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
108610918  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
108614196  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
108609275  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
108616713  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
108609769  probable small nuclear ribonucleoprotein E [KO:K11097]
108618862  probable small nuclear ribonucleoprotein G [KO:K11099]
108610814  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
108619401  U1 small nuclear ribonucleoprotein C [KO:K11095]
108611559  pre-mRNA-processing factor 40 homolog A [KO:K12821]
108619168  RNA-binding protein 25 isoform X1 [KO:K12822]
108621821  ATP-dependent RNA helicase p62 isoform X1 [KO:K12823] [EC:5.6.2.7]
108618369  ATP-dependent RNA helicase dbp2 [KO:K12823] [EC:5.6.2.7]
108614439  ATP-dependent RNA helicase p62-like [KO:K12823] [EC:5.6.2.7]
108613549  ATP-dependent RNA helicase dbp2 [KO:K12823] [EC:5.6.2.7]
108608824  transcription elongation regulator 1 isoform X1 [KO:K12824]
108619617  RNA-binding protein cabeza isoform X1 [KO:K13098]
108616032  probable U2 small nuclear ribonucleoprotein A' [KO:K11092]
108618718  U1 small nuclear ribonucleoprotein A [KO:K11094]
108620839  splicing factor 3A subunit 1 [KO:K12825]
108613713  splicing factor 3A subunit 2 [KO:K12826]
108621515  splicing factor 3A subunit 3 [KO:K12827]
108611528  splicing factor 3B subunit 1 [KO:K12828]
108611560  splicing factor 3B subunit 2 [KO:K12829]
108613888  splicing factor 3B subunit 3 [KO:K12830]
108618644  splicing factor 3B subunit 4 [KO:K12831]
108613529  splicing factor 3B subunit 6-like protein [KO:K12833]
108611403  uncharacterized protein CG9548 [KO:K12834]
108613337  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
108609756  splicing factor U2af 38 kDa subunit [KO:K12836]
108615090  splicing factor U2AF 50 kDa subunit [KO:K12837]
108617830  splicing factor U2AF 50 kDa subunit [KO:K12837]
108613322  poly(U)-binding-splicing factor half pint [KO:K12838]
108608858  survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
108611841  splicing factor 45 [KO:K12840]
108612484  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
108616526  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
108614586  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
108609306  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
108610919  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
108613461  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
108617108  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
108610142  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
108613048  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
108613022  U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
108613649  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
108616245  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
108613432  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
108611567  NHP2-like protein 1 homolog [KO:K12845]
108616137  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
108619487  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
108611619  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
108612513  zinc finger matrin-type protein 2 [KO:K12848]
108617105  pre-mRNA-splicing factor 38A [KO:K12849]
108619189  pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
108608707  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
108616711  pre-mRNA-processing-splicing factor 8 [KO:K12856]
108609752  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
108611631  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
108611054  thioredoxin-like protein 4A isoform X1 [KO:K12859]
108615689  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
108613293  cell division cycle 5-like protein [KO:K12860]
108611184  pre-mRNA-splicing factor SPF27 [KO:K12861]
108619250  pleiotropic regulator 1 [KO:K12862]
108617906  protein CWC15 homolog [KO:K12863]
108608746  beta-catenin-like protein 1 [KO:K12864]
108608704  heat shock 70 kDa protein cognate 4 [KO:K03283]
108616831  heat shock 70 kDa protein cognate 2 [KO:K03283]
108612602  heat shock 70 kDa protein cognate 1 [KO:K03283]
108612285  heat shock protein 68 [KO:K03283]
108608941  uncharacterized protein LOC108608941 [KO:K12865]
108618775  WW domain-binding protein 11 [KO:K12866]
108618776  puff-specific protein Bx42 [KO:K06063]
108611269  pre-mRNA-splicing factor SYF1 [KO:K12867]
108615506  pre-mRNA-splicing factor Syf2 [KO:K12868]
108619236  protein crooked neck [KO:K12869]
108621794  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
108621642  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1 [KO:K12733] [EC:5.2.1.8]
108617549  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
108621740  coiled-coil domain-containing protein 12 [KO:K12871]
108618021  pre-mRNA-splicing factor RBM22 [KO:K12872]
108617353  protein BUD31 homolog [KO:K12873]
108620653  protein BUD31 homolog [KO:K12873]
108621358  intron-binding protein aquarius [KO:K12874]
108611781  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
108621047  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
108615792  RNA-binding protein 8A [KO:K12876]
108617092  protein mago nashi [KO:K12877]
108608867  THO complex subunit 1 [KO:K12878]
108610227  THO complex subunit 2 isoform X1 [KO:K12879]
108620941  THO complex subunit 3 [KO:K12880]
108620728  THO complex subunit 4 [KO:K12881]
108611699  nuclear cap-binding protein subunit 1-like [KO:K12882]
108618267  nuclear cap-binding protein subunit 1 [KO:K12882]
108621779  nuclear cap-binding protein subunit 2 [KO:K12883]
108620790  heterogeneous nuclear ribonucleoprotein 87F [KO:K12741]
108621366  heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
108615894  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
108621728  serine/arginine-rich splicing factor 1B isoform X1 [KO:K12890]
108610493  serine/arginine-rich splicing factor 2 [KO:K12891]
108621266  RNA-binding protein 1 isoform X1 [KO:K12892]
108620791  serine-arginine protein 55 isoform X1 [KO:K12893]
108610663  probable splicing factor, arginine/serine-rich 6 [KO:K12896]
108611754  RNA-binding protein Rsf1 [KO:K12896]
108618241  RNA-binding protein 1 [KO:K12896]
108615826  transformer-2 sex-determining protein isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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