KEGG   PATHWAY: dord00600
Entry
dord00600                   Pathway                                
Name
Sphingolipid metabolism - Dipodomys ordii (Ord's kangaroo rat)
Class
Metabolism; Lipid metabolism
Pathway map
dord00600  Sphingolipid metabolism
dord00600

Module
dord_M00066  Lactosylceramide biosynthesis [PATH:dord00600]
dord_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:dord00600]
dord_M00094  Ceramide biosynthesis [PATH:dord00600]
dord_M00099  Sphingosine biosynthesis [PATH:dord00600]
dord_M00100  Sphingosine degradation [PATH:dord00600]
Other DBs
GO: 0006665
Organism
Dipodomys ordii (Ord's kangaroo rat) [GN:dord]
Gene
105981440  Sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
105986406  Sptlc2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
105993233  Sptlc1; serine palmitoyltransferase 1 isoform X1 [KO:K00654] [EC:2.3.1.50]
105987607  Kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
105994765  Cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
105984890  Cers2; ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
105998758  Cers4; ceramide synthase 4 [KO:K24621] [EC:2.3.1.297]
105982319  Cers3; ceramide synthase 3 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
105987427  Cers5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
105994475  Cers6; ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
105993070  Asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
105986279  neutral ceramidase-like [KO:K12349] [EC:3.5.1.23]
105990305  Acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
105988952  Acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
105983864  Acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
105984962  Degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
105984343  Degs2; sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
105991179  Sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
105986327  Sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
106000385  Smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
105990033  Smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
105983194  Smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
105997232  Smpd4; sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
106002138  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
105992712  Cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
105990482  Ppap2c; lipid phosphate phosphohydrolase 2 [KO:K01080] [EC:3.1.3.4]
105987356  Ppap2a; lipid phosphate phosphohydrolase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
105989998  Ppap2b; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
105983794  Sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
105987962  Sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
105994375  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
106001315  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
105986340  Sgpl1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
105990777  Ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
105984926  Gba; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
105993371  Gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
105984681  B4galt6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
105991655  B4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
105994858  Glb1; LOW QUALITY PROTEIN: beta-galactosidase [KO:K12309] [EC:3.2.1.23]
105991238  Ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
105983491  Galc; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
105984135  Gal3st1; galactosylceramide sulfotransferase isoform X1 [KO:K01019] [EC:2.8.2.11]
105992750  Arsa; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
105999824  Neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
105990170  Neu2; sialidase-2 [KO:K12357] [EC:3.2.1.18]
105983992  Neu3; sialidase-3 [KO:K12357] [EC:3.2.1.18]
105998825  Neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
105999934  Gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
105988581  B4galnt1; beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
105992375  Hexb; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
105982524  Hexa; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
105998958  Gm2a; ganglioside GM2 activator [KO:K12383]
105991248  Psapl1; proactivator polypeptide-like 1 [KO:K12382]
105992630  Psap; prosaposin [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
dord00260  Glycine, serine and threonine metabolism
dord00601  Glycosphingolipid biosynthesis - lacto and neolacto series
dord00603  Glycosphingolipid biosynthesis - globo and isoglobo series
dord00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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