KEGG   PATHWAY: efo00600
Entry
efo00600                    Pathway                                
Name
Sphingolipid metabolism - Epinephelus fuscoguttatus (brown-marbled grouper)
Class
Metabolism; Lipid metabolism
Pathway map
efo00600  Sphingolipid metabolism
efo00600

Module
efo_M00066  Lactosylceramide biosynthesis [PATH:efo00600]
efo_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:efo00600]
efo_M00094  Ceramide biosynthesis [PATH:efo00600]
efo_M00099  Sphingosine biosynthesis [PATH:efo00600]
efo_M00100  Sphingosine degradation [PATH:efo00600]
Other DBs
GO: 0006665
Organism
Epinephelus fuscoguttatus (brown-marbled grouper) [GN:efo]
Gene
125897074  sptlc2b; serine palmitoyltransferase 2b [KO:K00654] [EC:2.3.1.50]
125903712  sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
125905830  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
125900398  sptlc2a; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
125902181  kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
125895282  cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
125895612  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
125902189  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
125904670  cers2a; ceramide synthase 2a [KO:K24621] [EC:2.3.1.297]
125893374  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
125905346  cers3a; LOW QUALITY PROTEIN: ceramide synthase 2 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
125887456  cers3b; ceramide synthase 2 isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
125889337  cers5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
125891306  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
125899476  cers6; ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
125885453  asah1b; acid ceramidase [KO:K12348] [EC:3.5.1.23]
125881203  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
125896390  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
125885827  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
125898008  acer3; alkaline ceramidase 3 isoform X1 [KO:K04711] [EC:3.5.1.-]
125903997  degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
125900631  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
125883766  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
125903277  sgms1a; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
125885645  sgms2a; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
125898234  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
125894016  smpd2b; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
125893250  smpd5; sphingomyelin phosphodiesterase 5 isoform X1 [KO:K12352] [EC:3.1.4.12]
125887531  smpd3; sphingomyelin phosphodiesterase 3 isoform X1 [KO:K12352] [EC:3.1.4.12]
125894667  smpd4; sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
125879678  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
125892999  zgc:153896; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 isoform X1 [KO:K12354] [EC:3.1.4.12]
125881000  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like isoform X1 [KO:K12354] [EC:3.1.4.12]
125881242  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
125883139  cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
125891311  zgc:158263; ceramide kinase family protein [KO:K04715] [EC:2.7.1.138]
125887266  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
125895952  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
125896279  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
125890989  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
125878549  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
125886319  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
125879784  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
125901148  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
125901596  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
125896703  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
125901195  sgpp1b; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
125888257  sgpp2; sphingosine-1-phosphate phosphatase 2 isoform X1 [KO:K04717] [EC:3.1.3.-]
125886215  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
125879259  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
125893379  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
125903141  sgpl1; sphingosine-1-phosphate lyase 1 isoform X1 [KO:K01634] [EC:4.1.2.27]
125906313  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
125892582  gba; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
125884144  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
125895600  b4galt6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
125891080  b4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
125884362  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
125886638  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
125900948  galcb; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
125890922  gal3st1a; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
125885915  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
125906025  gal3st1b; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
125886725  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
125904526  neu1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
125885776  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
125898340  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
125888846  neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
125894122  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
125889274  b4galnt1b; beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
125891661  b4galnt1a; beta-1,4 N-acetylgalactosaminyltransferase 1a [KO:K00725] [EC:2.4.1.92]
125878647  hexb; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
125887095  hexa; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
125894820  ganglioside GM2 activator-like [KO:K12383]
125895003  gm2a; ganglioside GM2 activator [KO:K12383]
125903258  prosaposin [KO:K12382]
125890766  sftpbb; surfactant protein Bb [KO:K12382]
125905613  prosaposin [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
efo00260  Glycine, serine and threonine metabolism
efo00601  Glycosphingolipid biosynthesis - lacto and neolacto series
efo00603  Glycosphingolipid biosynthesis - globo and isoglobo series
efo00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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