KEGG   PATHWAY: epa03040
Entry
epa03040                    Pathway                                
Name
Spliceosome - Exaiptasia diaphana (Aiptasia)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
epa03040  Spliceosome
epa03040

Other DBs
GO: 0005681
Organism
Exaiptasia diaphana (Aiptasia) [GN:epa]
Gene
114576438  U2 spliceosomal RNA [KO:K14277]
114576730  U4 spliceosomal RNA [KO:K14278]
114575241  U4 spliceosomal RNA [KO:K14278]
114576706  U5 spliceosomal RNA [KO:K14279]
114576704  U5 spliceosomal RNA [KO:K14279]
114574955  U6 spliceosomal RNA [KO:K14280]
110254808  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
110245989  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
110246420  spliceosome RNA helicase Ddx39b [KO:K12812] [EC:5.6.2.7]
110233464  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
110248780  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
110231812  LOW QUALITY PROTEIN: pre-mRNA-processing factor 17-like [KO:K12816]
110247344  pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
110235061  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
110253037  ATP-dependent RNA helicase DEAH12, chloroplastic [KO:K12818] [EC:5.6.2.6]
110246142  pre-mRNA-splicing factor SLU7 [KO:K12819]
110246296  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 isoform X1 [KO:K12820] [EC:5.6.2.6]
110232217  small nuclear ribonucleoprotein-associated protein B' [KO:K11086]
110236559  small nuclear ribonucleoprotein Sm D1 [KO:K11087]
110247229  small nuclear ribonucleoprotein Sm D2 [KO:K11096]
110243978  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
110232985  LOW QUALITY PROTEIN: small nuclear ribonucleoprotein E-like [KO:K11097]
110250094  small nuclear ribonucleoprotein F [KO:K11098]
110238553  small nuclear ribonucleoprotein G [KO:K11099]
110242651  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
110233511  U1 small nuclear ribonucleoprotein A [KO:K11091]
110249035  pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
110240364  RNA-binding protein 25 [KO:K12822]
110251258  transcription elongation regulator 1 [KO:K12824]
110245386  RNA-binding protein FUS [KO:K13098]
110255097  U2 small nuclear ribonucleoprotein A' [KO:K11092]
110238806  splicing factor 3A subunit 1-like [KO:K12825]
110233524  splicing factor 3A subunit 2 [KO:K12826]
110239416  splicing factor 3A subunit 3 [KO:K12827]
110254764  splicing factor 3B subunit 1 isoform X1 [KO:K12828]
110235765  splicing factor 3B subunit 2 [KO:K12829]
110236520  splicing factor 3B subunit 3 [KO:K12830]
110239070  splicing factor 3B subunit 4 [KO:K12831]
114576614  splicing factor 3B subunit 5-like [KO:K12832]
110236148  splicing factor 3B subunit 6 [KO:K12833]
110246554  PHD finger-like domain-containing protein 5A [KO:K12834]
110249573  PHD finger-like domain-containing protein 5A [KO:K12834]
110254639  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
110251195  splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
110240030  splicing factor U2AF 65 kDa subunit [KO:K12837]
110251248  poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
110249353  survival of motor neuron-related-splicing factor 30 [KO:K12839]
110237958  splicing factor 45 [KO:K12840]
110234690  calcium homeostasis endoplasmic reticulum protein [KO:K12841]
110241170  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
110233401  retinitis pigmentosa 9 protein homolog [KO:K19604]
110244621  retinitis pigmentosa 9 protein homolog [KO:K19604]
110250267  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
110236762  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
110236707  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
110244101  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
110243051  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
110237851  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
110233967  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
110238664  U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
110244760  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
110239074  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
110247204  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
110240820  NHP2-like protein 1 [KO:K12845]
110245563  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
110241503  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
110254702  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
110244880  zinc finger matrin-type protein 2 [KO:K12848]
110231594  pre-mRNA-splicing factor 38A [KO:K12849]
110248854  pre-mRNA-splicing factor 38B [KO:K12850]
110234172  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
110234187  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
110238910  U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
110249405  pre-mRNA-processing factor 6 isoform X2 [KO:K12855]
110254473  pre-mRNA-processing-splicing factor 8 [KO:K12856]
110239124  LOW QUALITY PROTEIN: U5 small nuclear ribonucleoprotein 40 kDa protein-like [KO:K12857]
110234737  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
110234988  thioredoxin-like protein 4A [KO:K12859]
110233583  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
110250012  cell division cycle 5-related protein [KO:K12860]
110241797  pre-mRNA-splicing factor SPF27 [KO:K12861]
110240526  pleiotropic regulator 1 [KO:K12862]
110246772  spliceosome-associated protein CWC15 homolog [KO:K12863]
110245357  beta-catenin-like protein 1 [KO:K12864]
110232318  heat shock 70 kDa protein [KO:K03283]
110247847  heat shock 70 kDa protein 1B [KO:K03283]
110254734  heat shock cognate 71 kDa protein [KO:K03283]
110240270  polyglutamine-binding protein 1 [KO:K12865]
110241476  WW domain-binding protein 11 [KO:K12866]
110247053  SNW domain-containing protein 1 [KO:K06063]
110252781  pre-mRNA-splicing factor SYF1 [KO:K12867]
110248347  LOW QUALITY PROTEIN: pre-mRNA-splicing factor SYF2-like [KO:K12868]
110240993  crooked neck-like protein 1 [KO:K12869]
110233291  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
110253190  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
110242733  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
110253450  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
110243671  coiled-coil domain-containing protein 12 [KO:K12871]
110233503  pre-mRNA-splicing factor RBM22 [KO:K12872]
110246310  protein BUD31 homolog [KO:K12873]
110233948  RNA helicase aquarius [KO:K12874]
110253029  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
110238819  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
110245655  RNA-binding protein 8A isoform X1 [KO:K12876]
110237861  protein mago nashi homolog [KO:K12877]
110252215  THO complex subunit 1 [KO:K12878]
110248488  THO complex subunit 2 isoform X1 [KO:K12879]
110242743  THO complex subunit 3 isoform X2 [KO:K12880]
110239951  THO complex subunit 4 [KO:K12881]
110243098  nuclear cap-binding protein subunit 1 [KO:K12882]
110245457  nuclear cap-binding protein subunit 2 [KO:K12883]
110249096  nuclear cap-binding protein subunit 2 [KO:K12883]
110254220  heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
110251709  heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
110253684  RNA-binding protein Musashi homolog Rbp6 [KO:K12741]
110245146  RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
110243189  heterogeneous nuclear ribonucleoprotein K [KO:K12886]
110236463  serine/arginine-rich splicing factor 1B isoform X1 [KO:K12890]
110240026  serine/arginine-rich splicing factor 2 [KO:K12891]
110247637  serine/arginine-rich splicing factor 7 [KO:K12892]
110233615  serine-arginine protein 55 isoform X1 [KO:K12893]
110233032  serine/arginine-rich splicing factor 6 [KO:K12893]
110233131  serine-arginine protein 55 [KO:K12893]
110240697  serine/arginine-rich splicing factor 6 [KO:K12893]
110242388  serine/arginine-rich splicing factor 5 [KO:K12893]
110242389  serine/arginine-rich splicing factor 5 [KO:K12893]
110235190  serine/arginine-rich splicing factor 7 [KO:K12896]
110249430  serine/arginine-rich splicing factor RS2Z33 [KO:K12896]
110234111  transformer-2 protein homolog beta [KO:K12897]
110245554  serine/arginine-rich splicing factor 10 [KO:K12900]
110245556  serine/arginine-rich splicing factor 10 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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