KEGG   PATHWAY: gga04145
Entry
gga04145                    Pathway                                
Name
Phagosome - Gallus gallus (chicken)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
gga04145  Phagosome
gga04145

Other DBs
GO: 0045335
Organism
Gallus gallus (chicken) [GN:gga]
Gene
419368  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
769300  STX12; syntaxin-12 isoform X2 [KO:K13813]
426930  STX7; syntaxin-7 [KO:K08488]
776816  actin, cytoplasmic 2 [KO:K05692]
415296  ACTG1; actin, cytoplasmic type 5 [KO:K05692]
396526  ACTB; actin, cytoplasmic 1 [KO:K05692]
422848  STX18; syntaxin-18 [KO:K08492]
424377  SEC22B; vesicle-trafficking protein SEC22b precursor [KO:K08517]
417057  MHCIA6; class I histocompatibility antigen, F10 alpha chain [KO:K06751]
417067  MICA; class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
100859134  HLA-F10AL4; class I histocompatibility antigen, F10 alpha chain [KO:K06751]
100859374  MHCIA2; class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
107049124  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
107050538  class I histocompatibility antigen, F10 alpha chain-like isoform X2 [KO:K06751]
425389  BF2; Major histocompatibility complex class I antigen BF2 precursor [KO:K06751]
427746  YF5; MHC class I antigen YF5 precursor [KO:K06751]
430600  MHCIA7; class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
693260  BF1; MHC BF1 class I precursor [KO:K06751]
425256  BLB3; class II histocompatibility antigen, B-L beta chain isoform X1 [KO:K06752]
693256  BLB1; Major histocompatibility complex class II beta chain BLB1, (similar to HLA class II, D beta chain) precursor [KO:K06752]
417051  DMB2; major histocompatibility complex, class II, DM beta 2 precursor [KO:K06752]
417050  MHCDMA; B locus M alpha chain 1 precursor [KO:K06752]
430189  BLA; B-LA precursor [KO:K06752]
101747454  BLB2; uncharacterized protein LOC101747454 precursor [KO:K06752]
101748499  MHCBL2; class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752]
107057103  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
420649  RAB5A; ras-related protein Rab-5A [KO:K07887]
100529061  RAB5B; ras-related protein Rab-5B [KO:K07888]
395197  RAB5C; ras-related protein Rab-5C [KO:K07889]
417896  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
100857877  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
396191  TFR2; transferrin receptor protein 1 [KO:K06503]
428675  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
395821  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
776719  ATP6V1AL; V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
395497  ATP6V1B2; V-type proton ATPase subunit B [KO:K02147]
421939  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
420259  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
423280  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
418162  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
417249  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
424349  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
768854  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
769770  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
395474  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
395473  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
395472  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
418104  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
415674  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
420210  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
426199  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
416753  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
424575  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
427854  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
416016  RAB7A; ras-related protein Rab-7a [KO:K07897]
771782  RAB7B; ras-related protein Rab-7b [KO:K07898]
417558  RILP; rab-interacting lysosomal protein [KO:K13883]
423461  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
418979  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X2 [KO:K10414]
420571  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
424151  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 [KO:K10415]
415793  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
420668  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
776720  DYNC1LI2L; cytoplasmic dynein 1 light intermediate chain 2-like [KO:K10416]
107053365  cytoplasmic dynein 1 light intermediate chain 2-like [KO:K10416]
396426  TUBA8B; tubulin alpha-2 chain [KO:K07374]
416695  tubulin alpha chain [KO:K07374]
418166  TUBA8A; tubulin alpha-4 chain [KO:K07374]
421169  TUBA3E; tubulin alpha-8 chain [KO:K07374]
425049  tubulin alpha-3 chain [KO:K07374]
100857247  TUBA4A; tubulin alpha-5 chain-like [KO:K07374]
416694  TUBAL3; tubulin alpha-3 chain [KO:K07374]
100859737  TUBA1A1; tubulin alpha-1B chain [KO:K07374]
429035  TUBA1C; tubulin alpha-1 chain [KO:K07374]
100857858  TUBA1C; tubulin alpha-1C chain [KO:K07374]
100857214  TUBA4B; tubulin alpha-4A chain [KO:K07374]
396254  TUBB; tubulin beta-7 chain [KO:K07375]
396427  TUBB1; tubulin beta-6 chain [KO:K07375]
420883  TUBB2B; tubulin beta-2 chain [KO:K07375]
421037  TUBB6; tubulin beta-5 chain [KO:K07375]
431043  TUBB3; tubulin beta-4 chain [KO:K07375]
417255  TUBB4B; tubulin beta-3 chain [KO:K07375]
768337  TUBB2A; tubulin beta-1 chain-like [KO:K07375]
396220  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
414800  LAMP2; lysosome-associated membrane glycoprotein 2 precursor [KO:K06528]
424114  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
396044  M6PR; cation-dependent mannose-6-phosphate receptor isoform X4 [KO:K10089]
427721  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
417467  MPO; eosinophil peroxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
417466  LPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
427466  CTSV; cathepsin L1 precursor [KO:K01365] [EC:3.4.22.15]
420160  cathepsin L1-like isoform 1 precursor [KO:K01365] [EC:3.4.22.15]
425657  CTSS; cathepsin S precursor [KO:K01368] [EC:3.4.22.27]
416023  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
426369  SEC61A2; protein transport protein Sec61 subunit alpha [KO:K10956]
420997  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
776639  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
427727  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
427728  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100859104  CALR; calreticulin [KO:K08057]
420146  CALR3; calreticulin-3 precursor [KO:K08057]
416288  CANX; calnexin precursor [KO:K08054]
101750160  immunoglobulin epsilon heavy chain-like [KO:K06856]
418295  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
396181  ITGB2; integrin beta-2 precursor [KO:K06464]
396370  C3; complement C3 precursor [KO:K03990]
428649  COLEC11; collectin-11 precursor [KO:K10066]
421061  COLEC12; collectin-12 [KO:K10062]
374267  MBL2; mannose-binding lectin precursor [KO:K03991]
395308  SFTPA2; surfactant protein A2 precursor [KO:K10067]
423630  SFTPA1; surfactant protein A1 precursor [KO:K10067]
396420  ITGAV; integrin alpha-V precursor [KO:K06487]
100857227  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
374058  ITGB1; integrin beta-1 precursor [KO:K05719]
374209  ITGB3; integrin beta-3 precursor [KO:K06493]
395142  ITGB5; integrin beta-5 precursor [KO:K06588]
373987  THBS1; thrombospondin-1 precursor [KO:K16857]
414837  THBS2; thrombospondin-2 precursor [KO:K04659]
420120  COMP; cartilage oligomeric matrix protein [KO:K04659]
396306  THBS4; thrombospondin 4 precursor [KO:K04659]
374141  TLR2A; toll-like receptor 2 type-1 precursor [KO:K10159]
769014  TLR2B; toll-like receptor 2 type-2 precursor [KO:K10159]
426274  TLR1A; toll-like receptor1 precursor [KO:K10169]
417241  TLR4; toll-like receptor 4 precursor [KO:K10160]
100194427  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
404304  PLA2R1; secretory phospholipase A2 receptor precursor [KO:K06560]
419950  MRC2; C-type mannose receptor 2 [KO:K06560]
420515  MMR1L3; macrophage mannose receptor 1-like 3 precursor [KO:K06560]
420516  MRC1; mannose receptor C-type 1 precursor [KO:K06560]
428421  MMR1L2; macrophage mannose receptor 1-like 2 precursor [KO:K06560]
771876  MMR1L1; macrophage mannose receptor 1-like 1 precursor [KO:K06560]
771888  MMR1L4; macrophage mannose receptor 1-like 4 precursor [KO:K06560]
396477  hepatic lectin [KO:K06563]
395488  MARCO; macrophage receptor MARCO [KO:K13884]
416814  SCARB1; scavenger receptor class B member 1 isoform X2 [KO:K13885]
417730  CD36; platelet glycoprotein 4 [KO:K06259]
100859840  CYBA; cytochrome b-245 light chain [KO:K08009]
418581  CYBB; cytochrome b-245 beta chain [KO:K21421] [EC:1.-.-.-]
395871  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
417485  NCF1; neutrophil cytosol factor 1 [KO:K08011]
424445  NCF2; neutrophil cytosol factor 2 [KO:K08010]
418052  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
gga04142  Lysosome
gga04144  Endocytosis
gga04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
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