KEGG   PATHWAY: ggn03040
Entry
ggn03040                    Pathway                                
Name
Spliceosome - Gavialis gangeticus (Gharial)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
ggn03040  Spliceosome
ggn03040

Other DBs
GO: 0005681
Organism
Gavialis gangeticus (Gharial) [GN:ggn]
Gene
109289951  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
109289244  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
109299612  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
109292203  PRPF18; pre-mRNA-splicing factor 18 [KO:K12817]
109302118  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
109290090  SLU7; pre-mRNA-splicing factor SLU7 isoform X1 [KO:K12819]
109303626  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
109292464  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
109291772  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
109290387  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
109295216  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
109296392  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
109295352  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
109301308  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
109298820  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
109296972  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
109290009  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
109288457  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
109296737  SNRPB2; U2 small nuclear ribonucleoprotein B'' isoform X1 [KO:K11094]
109290310  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
109294830  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
109294225  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
109301870  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
109289668  SF3B3; splicing factor 3B subunit 3 isoform X1 [KO:K12830]
109296960  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
109304766  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
109300204  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
109295944  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
109302098  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
109302751  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
109305258  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
109287604  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
109292240  RBM17; splicing factor 45 [KO:K12840]
109295015  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
109288147  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
109291833  RP9; retinitis pigmentosa 9 protein [KO:K19604]
109289042  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
109294996  LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
109291828  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
109301195  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
109294670  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
109292803  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
109293872  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
109286893  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 isoform X1 [KO:K12844]
109295938  SNU13; NHP2-like protein 1 [KO:K12845]
109295496  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
109295520  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
109301655  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
109289802  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
109286656  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
109287110  PRPF38B; pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
109302048  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
109291338  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase isoform X1 [KO:K12854] [EC:5.6.2.6]
109292573  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
109293399  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
109293977  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
109302442  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
109300278  CDC5L; cell division cycle 5-like protein [KO:K12860]
109295325  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
109300831  PLRG1; pleiotropic regulator 1 [KO:K12862]
109303240  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
109292488  CTNNBL1; beta-catenin-like protein 1 isoform X1 [KO:K12864]
109294207  heat shock 70 kDa protein 1A-like [KO:K03283]
109297365  heat shock 70 kDa protein II-like [KO:K03283]
109292446  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
109298569  SNW1; SNW domain-containing protein 1 [KO:K06063]
109294148  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
109296645  CRNKL1; crooked neck-like protein 1 [KO:K12869]
109289140  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
109295168  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 isoform X1 [KO:K12733] [EC:5.2.1.8]
109294106  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
109289879  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
109294329  BUD31; protein BUD31 homolog [KO:K12873]
109298702  AQR; intron-binding protein aquarius [KO:K12874]
109296679  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
109296478  RBM8A; LOW QUALITY PROTEIN: RNA-binding protein 8A [KO:K12876]
109286640  MAGOH; protein mago nashi homolog [KO:K12877]
109303771  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
109300766  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
109289832  THOC3; THO complex subunit 3 [KO:K12880]
109298073  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
109300565  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
109301758  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
109300610  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
109297557  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
109294733  HNRNPM; heterogeneous nuclear ribonucleoprotein M [KO:K12887]
109304469  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
109293250  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
109287683  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
109295208  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
109293912  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
109294611  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
109298839  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
109296686  serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
109296690  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
109290347  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
109294310  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
109291552  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
109294129  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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