KEGG   PATHWAY: gste04625
Entry
gste04625                   Pathway                                
Name
C-type lectin receptor signaling pathway - Gavia stellata (red-throated loon)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
gste04625  C-type lectin receptor signaling pathway
gste04625

Organism
Gavia stellata (red-throated loon) [GN:gste]
Gene
104256041  LSP1; lymphocyte-specific protein 1 [KO:K14957]
104254756  HRAS; GTPase HRas [KO:K02833]
104250297  GTPase HRas [KO:K07827]
104260191  GTPase NRas [KO:K07828]
104262633  MRAS; ras-related protein M-Ras [KO:K07831]
104254364  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104251683  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
104260245  IL12B; interleukin-12 subunit beta [KO:K05425]
104255974  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
104263928  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
104261814  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
104263875  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104260485  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104250779  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
104253546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
104257964  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104263844  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104264423  LOW QUALITY PROTEIN: calmodulin-A-like [KO:K02183]
104252770  calmodulin [KO:K02183]
104250866  CALML4; calmodulin-like protein 4 [KO:K02183]
104262516  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104258085  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104264770  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104252255  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104261207  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104257465  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
104251414  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
104256903  interleukin-15-like [KO:K05429]
104253454  IL10; LOW QUALITY PROTEIN: interleukin-10 [KO:K05443]
104264982  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
104261920  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
104265038  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104264268  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
104251815  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
104252423  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
104253027  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
104261757  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
104255507  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104262083  caspase-8-like [KO:K04398] [EC:3.4.22.61]
104250915  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104258165  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104261864  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104250287  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104254581  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104251718  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104251557  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104255912  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104261666  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104262317  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
104253202  JUN; transcription factor AP-1 [KO:K04448]
104256257  hepatic lectin-like [KO:K06563]
104254954  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
104261228  RHOA; transforming protein RhoA [KO:K04513]
104263993  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104257490  KSR1; kinase suppressor of Ras 1 [KO:K14958]
104255518  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
104259693  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
104254457  IL17D; interleukin-17D [KO:K05492]
104257954  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
104259330  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
104261014  C-C motif chemokine 5-like [KO:K21083]
104258937  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104260572  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104261063  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104262659  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
104259647  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104257515  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104253346  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104263412  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104251128  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104264416  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104258917  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   
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