Entry Name Vasopressin-regulated water reabsorption - Homo sapiens (human)
Description In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again.
Class Organismal Systems; Excretory systemBRITE hierarchy
Pathway map hsa04962 Vasopressin-regulated water reabsorption
Ortholog table Network Element N00915 AVP-V2R-PKA signaling pathway
Drug D01213 Tolvaptan (JAN/USAN/INN)
D01236 Conivaptan hydrochloride (JAN/USAN)
D01855 Mozavaptane hydrochloride (JAN)
D02235 Desmopressin acetate (USP)
D02983 Argipressin tannate (USAN)
D06672 Terlipressin (USAN/INN)
D08571 Terlipressin acetate (JAN)
D09820 Vasopressin tannate (JAN)
D11659 Tolvaptan sodium phosphate (JAN)
Organism Homo sapiens (human) [GN:
hsa ]
Gene 554 AVPR2; arginine vasopressin receptor 2 [KO:K04228 ]
397 ARHGDIB; Rho GDP dissociation inhibitor beta [KO:K12462 ]
396 ARHGDIA; Rho GDP dissociation inhibitor alpha [KO:K12462 ]
398 ARHGDIG; Rho GDP dissociation inhibitor gamma [KO:K12462 ]
1385 CREB1; cAMP responsive element binding protein 1 [KO:K05870 ]
10488 CREB3; cAMP responsive element binding protein 3 [KO:K09048 ]
90993 CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048 ]
64764 CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048 ]
84699 CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048 ]
148327 CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048 ]
9586 CREB5; cAMP responsive element binding protein 5 [KO:K09047 ]
8766 RAB11A; RAB11A, member RAS oncogene family [KO:K07904 ]
9230 RAB11B; RAB11B, member RAS oncogene family [KO:K07905 ]
1778 DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413 ]
79659 DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414 ]
1780 DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415 ]
1781 DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415 ]
1783 DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416 ]
51143 DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416 ]
51626 DYNC2LI1; dynein cytoplasmic 2 light intermediate chain 1 [KO:K10417 ]
8655 DYNLL1; dynein light chain LC8-type 1 [KO:K10418 ]
6844 VAMP2; vesicle associated membrane protein 2 [KO:K13504 ]
4905 NSF; N-ethylmaleimide sensitive factor, vesicle fusing ATPase [KO:K06027 ] [EC:3.6.4.6 ]
5868 RAB5A; RAB5A, member RAS oncogene family [KO:K07887 ]
5869 RAB5B; RAB5B, member RAS oncogene family [KO:K07888 ]
5878 RAB5C; RAB5C, member RAS oncogene family [KO:K07889 ]
360 AQP3; aquaporin 3 (Gill blood group) [KO:K09876 ]
Compound Reference Authors Boone M, Deen PM
Title Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Journal Reference Authors Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T
Title Localization and trafficking of aquaporin 2 in the kidney.
Journal Reference Authors Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frokiaer J, Marples D
Title Physiology and pathophysiology of renal aquaporins.
Journal J Am Soc Nephrol 10:647-63 (1999)
Reference Authors Marples D, Frokiaer J, Nielsen S
Title Long-term regulation of aquaporins in the kidney.
Journal Reference Authors Ward DT, Hammond TG, Harris HW
Title Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.
Journal Reference Authors Fenton RA, Moeller HB
Title Recent discoveries in vasopressin-regulated aquaporin-2 trafficking.
Journal Reference Authors Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA
Title Aquaporins in the kidney: from molecules to medicine.
Journal Reference Authors Deen PM, van Balkom BW, Kamsteeg EJ
Title Routing of the aquaporin-2 water channel in health and disease.
Journal Reference Authors Bonilla-Felix M
Title Development of water transport in the collecting duct.
Journal Reference Authors Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA
Title Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.
Journal Reference Authors Nguyen MK, Nielsen S, Kurtz I
Title Molecular pathogenesis of nephrogenic diabetes insipidus.
Journal Related KO pathway LinkDB All DBs
