KEGG   PATHWAY: hsa04530
Entry
hsa04530                    Pathway                                
Name
Tight junction - Homo sapiens (human)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
hsa04530  Tight junction
hsa04530

Network
nt06166  Human papillomavirus (HPV)
nt06180  Pathogenic Escherichia coli
  Element
N00340  The Scribble/Dlg/Lgl polarity module
N00344  CRB3-Pals1-PATJ complex
N01287  Tight junction-Actin signaling pathway
Drug
D09916  Ivacaftor (USAN/INN)
D10685  Lumacaftor and ivacaftor
D11042  Tezacaftor and ivacaftor
D11527  Zolbetuximab (USAN/INN)
D11700  Elexacaftor, ivacaftor and tezacaftor
D12722  Bexotegrast (USAN/INN)
D12781  Osemitamab (USAN/INN)
D12997  Lixudebart (USAN/INN)
D13024  Vanzacaftor, tezacaftor and deutivacaftor
D13158  Spevatamig (USAN/INN)
D13163  Sonesitatug (USAN/INN)
D13164  Sonesitatug vedotin (USAN/INN)
D13271  Ixotatug (USAN/INN)
D13340  Ixotatug vedotin (USAN/INN)
Other DBs
GO: 0005923
Organism
Homo sapiens (human) [GN:hsa]
Gene
100132463  CLDN24; claudin-24 [KO:K06087]
100288814  CLDN34; claudin-34 [KO:K06087]
100506658  OCLN; occludin isoform a [KO:K06088]
10092  ARPC5; actin-related protein 2/3 complex subunit 5 isoform 1 [KO:K05754]
10093  ARPC4; actin-related protein 2/3 complex subunit 4 isoform a [KO:K05755]
10094  ARPC3; actin-related protein 2/3 complex subunit 3 isoform 1 [KO:K05756]
10095  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
10096  ACTR3; actin-related protein 3 isoform 1 [KO:K18584]
10097  ACTR2; actin-related protein 2 isoform b [KO:K17260]
10109  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
1019  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
10207  PATJ; inaD-like protein isoform 1 [KO:K06092]
10376  TUBA1B; tubulin alpha-1B chain [KO:K07374]
103910  MYL12B; myosin regulatory light chain 12B [KO:K12757]
10398  MYL9; myosin regulatory light polypeptide 9 isoform a [KO:K12755]
10552  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform 1 [KO:K05757]
10627  MYL12A; myosin regulatory light chain 12A isoform 1 [KO:K12757]
10686  CLDN16; claudin-16 [KO:K06087]
1080  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
11149  POPDC1; popeye domain-containing protein 1 [KO:K21108]
112714  TUBA3E; tubulin alpha-3E chain [KO:K07374]
113457  TUBA3D; tubulin alpha-3D chain [KO:K07374]
11346  SYNPO; synaptopodin isoform C [KO:K21112]
123720  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
1364  CLDN4; claudin-4 [KO:K06087]
1365  CLDN3; claudin-3 [KO:K06087]
1366  CLDN7; claudin-7 isoform 1 [KO:K06087]
137075  CLDN23; claudin-23 [KO:K06087]
140465  MYL6B; myosin light chain 6B [KO:K12751]
149461  CLDN19; claudin-19 isoform a [KO:K06087]
150084  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
153562  MARVELD2; MARVEL domain-containing protein 2 isoform 1 [KO:K17291]
154796  AMOT; angiomotin isoform 1 [KO:K16819]
154810  AMOTL1; angiomotin-like protein 1 isoform 1 [KO:K06104]
1739  DLG1; disks large homolog 1 isoform 1 [KO:K12076]
1740  DLG2; disks large homolog 2 isoform 2 [KO:K12075]
1741  DLG3; disks large homolog 3 isoform a [KO:K21098]
2017  CTTN; src substrate cortactin isoform a [KO:K06106]
2064  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform a precursor [KO:K05083] [EC:2.7.10.1]
23327  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform 1 [KO:K13305] [EC:2.3.2.26]
23370  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform c [KO:K21066]
23513  SCRIB; protein scribble homolog isoform a [KO:K16175]
23562  CLDN14; claudin-14 [KO:K06087]
24146  CLDN15; claudin-15 [KO:K06087]
2626  GATA4; transcription factor GATA-4 isoform 2 [KO:K09183]
26285  CLDN17; claudin-17 [KO:K06087]
27134  TJP3; tight junction protein ZO-3 isoform 1 [KO:K06097]
3059  HCLS1; hematopoietic lineage cell-specific protein isoform 1 [KO:K06106]
3308  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
3688  ITGB1; integrin beta-1 isoform 1A precursor [KO:K05719]
3725  JUN; transcription factor Jun [KO:K04448]
387  RHOA; transforming protein RhoA isoform 1 precursor [KO:K04513]
3993  LLGL2; LLGL scribble cell polarity complex component 2 isoform c [KO:K06094]
3996  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
4214  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
4217  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform 2 [KO:K04426] [EC:2.7.11.25]
4218  RAB8A; ras-related protein Rab-8A [KO:K07901]
4301  AFDN; afadin isoform 6 [KO:K05702]
4478  MSN; moesin isoform 1 [KO:K05763]
4627  MYH9; myosin-9 [KO:K10352]
4628  MYH10; myosin-10 isoform 2 [KO:K10352]
4629  MYH11; myosin-11 isoform SM1A [KO:K10352]
4633  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 1 [KO:K10351]
4637  MYL6; myosin light polypeptide 6 isoform 1 [KO:K12751]
4734  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform 3 [KO:K10591] [EC:2.3.2.26]
4771  NF2; merlin isoform 1 [KO:K16684]
49861  CLDN20; claudin-20 precursor [KO:K06087]
5010  CLDN11; claudin-11 isoform 1 [KO:K06087]
50848  F11R; junctional adhesion molecule A isoform 1 precursor [KO:K06089]
50855  PARD6A; partitioning defective 6 homolog alpha isoform 1 [KO:K06093]
5111  PCNA; proliferating cell nuclear antigen [KO:K04802]
51208  CLDN18; claudin-18 isoform 1 [KO:K06087]
51421  AMOTL2; angiomotin-like protein 2 isoform 4 [KO:K06104]
51422  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform a [KO:K07200]
51735  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform 2 [KO:K08020]
51762  RAB8B; ras-related protein Rab-8B [KO:K07902]
51807  TUBA8; tubulin alpha-8 chain isoform 1 [KO:K07374]
53632  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
53842  CLDN22; claudin-22 [KO:K06087]
54566  EPB41L4B; band 4.1-like protein 4B isoform 2 [KO:K21111]
55114  ARHGAP17; rho GTPase-activating protein 17 isoform 1 [KO:K20638]
5515  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1 [KO:K04382] [EC:3.1.3.16]
5516  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
5518  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 1 [KO:K03456]
5519  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a [KO:K03456]
5520  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1 [KO:K04354]
5521  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform e [KO:K04354]
5522  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform a [KO:K04354]
5562  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 [KO:K07198] [EC:2.7.11.31]
5563  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
5564  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
5565  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
5566  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 [KO:K04345] [EC:2.7.11.11]
5567  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
5568  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
5571  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform 1 [KO:K07200]
5581  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
5584  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
55844  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform a [KO:K04354]
5590  PRKCZ; protein kinase C zeta type isoform 1 [KO:K18952] [EC:2.7.11.13]
5599  MAPK8; mitogen-activated protein kinase 8 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
5609  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform 3 [KO:K04431] [EC:2.7.12.2]
56288  PARD3; partitioning defective 3 homolog isoform 1 [KO:K04237]
57180  ACTR3B; actin-related protein 3B isoform 1 [KO:K18584]
57530  CGN; cingulin [KO:K06102]
57826  RAP2C; ras-related protein Rap-2c isoform 1 precursor [KO:K07839]
58494  JAM2; junctional adhesion molecule B isoform 1 precursor [KO:K06735]
58538  MPP4; MAGUK p55 subfamily member 4 isoform 1 [KO:K21109]
5872  RAB13; ras-related protein Rab-13 isoform 1 [KO:K06109]
5879  RAC1; ras-related C3 botulinum toxin substrate 1 isoform Rac1 [KO:K04392]
5906  RAP1A; ras-related protein Rap-1A precursor [KO:K04353]
595  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
5962  RDX; radixin isoform 2 [KO:K05762]
60  ACTB; actin, cytoplasmic 1 [KO:K05692]
6093  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
64398  PALS1; protein PALS1 isoform 1 [KO:K06091]
644672  CLDN25; claudin-25 [KO:K06087]
653857  ACTR3C; actin-related protein 3C isoform a precursor [KO:K18584]
6714  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
6794  STK11; serine/threonine-protein kinase STK11 isoform 1 [KO:K07298] [EC:2.7.11.1]
7074  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform 1 [KO:K05731]
7082  TJP1; tight junction protein 1 isoform a [KO:K05701]
71  ACTG1; actin, cytoplasmic 2 [KO:K05692]
7122  CLDN5; claudin-5 isoform 2 [KO:K06087]
7277  TUBA4A; tubulin alpha-4A chain isoform 1 [KO:K07374]
7278  TUBA3C; tubulin alpha-3C chain [KO:K07374]
7408  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
7430  EZR; ezrin [KO:K08007]
7454  WAS; actin nucleation-promoting factor WAS isoform 1 [KO:K05747]
776  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform b [KO:K04851]
7846  TUBA1A; tubulin alpha-1A chain isoform 1 [KO:K07374]
79778  MICALL2; MICAL-like protein 2 [KO:K21068]
79784  MYH14; myosin-14 isoform 2 [KO:K10352]
79861  TUBAL3; tubulin alpha chain-like 3 isoform 1 [KO:K07374]
81  ACTN4; alpha-actinin-4 isoform 1 [KO:K05699]
81873  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
8189  SYMPK; symplekin [KO:K06100]
83700  JAM3; junctional adhesion molecule C isoform 1 precursor [KO:K06785]
84552  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
84612  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
84790  TUBA1C; tubulin alpha-1C chain isoform c [KO:K07374]
84952  CGNL1; cingulin-like protein 1 [KO:K21110]
8531  YBX3; Y-box-binding protein 3 isoform a [KO:K06099]
861  RUNX1; runt-related transcription factor 1 isoform AML1b [KO:K08367]
87  ACTN1; alpha-actinin-1 isoform b [KO:K05699]
8777  MPDZ; multiple PDZ domain protein isoform 4 [KO:K06095]
9069  CLDN12; claudin-12 [KO:K06087]
9071  CLDN10; claudin-10 isoform b [KO:K06087]
9073  CLDN8; claudin-8 [KO:K06087]
9074  CLDN6; claudin-6 [KO:K06087]
9075  CLDN2; claudin-2 [KO:K06087]
9076  CLDN1; claudin-1 [KO:K06087]
9080  CLDN9; claudin-9 [KO:K06087]
909  CD1A; T-cell surface glycoprotein CD1a isoform 1 precursor [KO:K06448]
910  CD1B; T-cell surface glycoprotein CD1b precursor [KO:K06448]
911  CD1C; T-cell surface glycoprotein CD1c precursor [KO:K06448]
912  CD1D; antigen-presenting glycoprotein CD1d isoform 1 precursor [KO:K06448]
913  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform a precursor [KO:K06448]
9181  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform 1 [KO:K12791]
91862  MARVELD3; MARVEL domain-containing protein 3 isoform 2 [KO:K21099]
9223  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c [KO:K05631]
92359  CRB3; protein crumbs homolog 3 isoform a precursor [KO:K06090]
93643  TJAP1; tight junction-associated protein 1 isoform a [KO:K06105]
9368  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
9414  TJP2; tight junction protein 2 isoform 1 [KO:K06098]
9475  ROCK2; rho-associated protein kinase 2 isoform 1 [KO:K17388] [EC:2.7.11.39]
9693  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform 5 [KO:K08018]
998  CDC42; cell division control protein 42 homolog isoform 1 precursor [KO:K04393]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
hsa04520  Adherens junction
hsa04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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