KEGG   PATHWAY: lco04150
Entry
lco04150                    Pathway                                
Name
mTOR signaling pathway - Larimichthys crocea (large yellow croaker)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
lco04150  mTOR signaling pathway
lco04150

Organism
Larimichthys crocea (large yellow croaker) [GN:lco]
Gene
104935930  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
104920210  large neutral amino acids transporter small subunit 1 isoform X1 [KO:K13780]
104929379  4F2 cell-surface antigen heavy chain [KO:K06519]
104937562  4F2 cell-surface antigen heavy chain [KO:K06519]
104937690  slc3a2; 4F2 cell-surface antigen heavy chain [KO:K06519]
104939284  slc38a9; sodium-coupled neutral amino acid transporter 9 isoform X2 [KO:K14995]
109141826  atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104929394  V-type proton ATPase subunit B, brain isoform [KO:K02147]
104935770  LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147]
104926070  V-type proton ATPase subunit C 1-B [KO:K02148]
104937165  V-type proton ATPase subunit C 1-A [KO:K02148]
104931583  atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
104924929  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
104940272  V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
109141503  atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
104938441  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
104937366  V-type proton ATPase subunit G 1-like [KO:K02152]
104917738  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
104920126  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
104932165  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
104922569  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
104938443  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
104926711  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
104929739  flcn; folliculin isoform X1 [KO:K09594]
104921038  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
109136711  ras-related GTP-binding protein A [KO:K16185]
109137645  rragc; ras-related GTP-binding protein C [KO:K16186]
104921534  ras-related GTP-binding protein C [KO:K16186]
104936004  ras-related GTP-binding protein D isoform X1 [KO:K16186]
104922075  sestrin-2 isoform X1 [KO:K20394]
104923684  cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
104923981  cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
109139840  mios; GATOR complex protein MIOS [KO:K20407]
104936233  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
104919694  wdr24; GATOR complex protein WDR24 [KO:K20408]
104931983  sec13; protein SEC13 homolog [KO:K14004]
104931867  depdc5; GATOR complex protein DEPDC5 isoform X2 [KO:K20404]
104930953  nprl2; GATOR complex protein NPRL2 [KO:K20405]
104918694  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
104938172  skp2; S-phase kinase-associated protein 2 isoform X2 [KO:K03875]
104931683  rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
104921544  rptor; regulatory-associated protein of mTOR isoform X2 [KO:K07204]
104939070  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
104919512  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
104939571  DEP domain-containing mTOR-interacting protein [KO:K20402]
104937887  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
104918918  mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
104919683  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
104929164  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
104920291  clip1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
104937607  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
104934758  growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
104937108  growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
104936292  phosphatidate phosphatase LPIN2 isoform X2 [KO:K15728] [EC:3.1.3.4]
104926156  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
104921770  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
104925299  lpin2; phosphatidate phosphatase LPIN2 isoform X2 [KO:K15728] [EC:3.1.3.4]
104925645  lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
104933467  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
104920108  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
104930671  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
104920315  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104920089  eukaryotic translation initiation factor 4E-binding protein 2 isoform X1 [KO:K07205]
104917906  eukaryotic translation initiation factor 4E-1A [KO:K03259]
104935096  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X5 [KO:K03259]
104934894  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
104929590  eukaryotic translation initiation factor 4E-1A [KO:K03259]
104930148  eukaryotic translation initiation factor 4E-like [KO:K03259]
104933515  rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104930044  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
104937286  eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
104930182  rps6; 40S ribosomal protein S6 [KO:K02991]
104930220  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
104921753  STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
104929660  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104920572  calcium-binding protein 39 [KO:K08272]
104929106  calcium-binding protein 39 [KO:K08272]
104919395  cab39; calcium-binding protein 39 [KO:K08272]
104924922  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
104919125  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
104923614  tsc1; hamartin [KO:K07206]
104927875  tsc2; tuberin isoform X2 [KO:K07207]
104932408  TBC1 domain family member 7 [KO:K20396]
104932042  rheb; GTP-binding protein Rheb [KO:K07208]
104938403  GTP-binding protein Rheb [KO:K07208]
104928555  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
104930521  DNA damage-inducible transcript 4 protein [KO:K08270]
104932478  wnt1; proto-oncogene Wnt-1 [KO:K03209]
104922301  protein Wnt-2b-A [KO:K00182]
104925521  wnt2; protein Wnt-2 isoform X1 [KO:K00182]
104932064  protein Wnt-2b-A [KO:K00182]
104925160  proto-oncogene Wnt-3 [KO:K00312]
109141721  wnt3a; protein Wnt-3a [KO:K00312]
104923622  wnt4; protein Wnt-4 [KO:K00408]
104932544  protein Wnt-4 [KO:K00408]
104931731  wnt5a; protein Wnt-5a [KO:K00444]
104924622  wnt5b; protein Wnt-5b isoform X2 [KO:K00444]
104919603  wnt6; protein Wnt-6 [KO:K00445]
104940226  protein Wnt-7a [KO:K00572]
104929678  protein Wnt-7a [KO:K00572]
104921012  protein Wnt-7b isoform X2 [KO:K00572]
104933513  protein Wnt-7b isoform X1 [KO:K00572]
104930490  wnt8b; protein Wnt-8b [KO:K00714]
104924241  protein Wnt-8 [KO:K00714]
104924242  protein Wnt-8a-like [KO:K00714]
104923918  protein Wnt-9b [KO:K01064]
109140386  wnt9a; protein Wnt-9a isoform X1 [KO:K01064]
104932464  wnt10b; protein Wnt-10b isoform X2 [KO:K01357]
104919614  wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
104933905  wnt11; protein Wnt-11 [KO:K01384]
104934562  wnt16; protein Wnt-16 [KO:K01558]
104925482  frizzled-1 isoform X1 [KO:K02432]
104936971  frizzled-7-A [KO:K02432]
104925888  fzd2; frizzled-2 [KO:K02235]
104940210  frizzled-3 [KO:K02329]
104927081  fzd3; frizzled-3 isoform X1 [KO:K02329]
104920116  fzd4; frizzled-4 [KO:K02354]
104923589  frizzled-5 [KO:K02375]
104929446  frizzled-8 [KO:K02375]
104927254  fzd8; frizzled-8 [KO:K02375]
104923779  fzd6; frizzled-6 [KO:K02376]
104923087  fzd10; frizzled-10 [KO:K02842]
109138626  fzd9; frizzled-9 [KO:K02842]
104933402  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
104939163  low-density lipoprotein receptor-related protein 5 [KO:K03068]
104937819  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
104924672  dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
104933929  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
104934174  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
104936875  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104931067  tumor necrosis factor [KO:K03156]
104931068  tumor necrosis factor-like [KO:K03156]
104933337  tumor necrosis factor-like [KO:K03156]
104929001  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104921662  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104923900  insulin isoform X1 [KO:K04526]
109142434  ins; insulin [KO:K04526]
104931882  insulin isoform X1 [KO:K04526]
104935275  insulin-like growth factor I [KO:K05459]
104926290  igf1; insulin-like growth factor I precursor [KO:K05459]
104926189  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
104920253  insulin receptor [KO:K04527] [EC:2.7.10.1]
104920736  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104921706  LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104929435  grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104935981  sos2; son of sevenless homolog 2 [KO:K03099]
104935443  sos1; son of sevenless homolog 1 [KO:K03099]
104920460  hras; GTPase HRas [KO:K02833]
104924376  kras; GTPase KRas isoform X1 [KO:K07827]
104930345  GTPase HRas [KO:K07827]
104938610  braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104940217  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104922316  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104920827  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104929670  dual specificity mitogen-activated protein kinase kinase 2-like isoform X1 [KO:K04369] [EC:2.7.12.2]
104929510  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104932685  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104934069  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104940400  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
104920608  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104927893  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
104923989  insulin receptor substrate 1-B [KO:K16172]
104935068  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104928409  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104935222  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104930938  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
104921004  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104934458  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
104927097  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104919391  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104934900  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104921281  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104933269  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104936542  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104929647  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104923215  pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
104918516  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104940519  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104931217  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104924791  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104935530  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104930409  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104928982  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104934740  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
104928039  rapamycin-insensitive companion of mTOR isoform X2 [KO:K08267]
104930662  rictor; rapamycin-insensitive companion of mTOR [KO:K08267]
104940542  proline-rich protein 5 isoform X2 [KO:K20411]
104940455  proline-rich protein 5 isoform X1 [KO:K20411]
104938934  prr5l; proline-rich protein 5-like [KO:K20411]
104933039  rho-related GTP-binding protein RhoA-C [KO:K04513]
104933314  transforming protein RhoA [KO:K04513]
104931794  rho-related GTP-binding protein RhoA-C [KO:K04513]
104932082  transforming protein RhoA [KO:K04513]
104918352  rho-related GTP-binding protein RhoA-B [KO:K04513]
104918810  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104927125  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104929965  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104917655  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104929793  protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
104923042  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
104937362  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
104925665  sgk1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
lco00561  Glycerolipid metabolism
lco04010  MAPK signaling pathway
lco04140  Autophagy - animal
lco04810  Regulation of actin cytoskeleton
lco04910  Insulin signaling pathway
KO pathway
ko04150   
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