Entry Name Fc epsilon RI signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map lve04664 Fc epsilon RI signaling pathway
Ortholog table Other DBs Organism Lipotes vexillifer (Yangtze River dolphin) [GN:
lve ]
Gene 103075075 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856 ]
103075361 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856 ]
103077379 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089 ]
103091403 MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090 ]
103085198 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
103068930 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
103070997 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
103089257 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
103088756 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
103085303 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103070370 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
103078725 PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
103083960 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
103074749 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
103081641 LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433 ] [EC:2.7.12.2 ]
103089107 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
103082841 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
103088874 VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
103084123 LAT; linker for activation of T-cells family member 1 [KO:K07362 ]
103079766 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
103069504 ALOX5AP; arachidonate 5-lipoxygenase-activating protein [KO:K20735 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kawakami T, Galli SJ.
Title Regulation of mast-cell and basophil function and survival by IgE.
Journal Reference Authors Siraganian RP.
Title Mast cell signal transduction from the high-affinity IgE receptor.
Journal Reference Authors Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title Immunobiology 6th edition
Journal Garland Science Publishing (2005)
Reference Authors Turner H, Kinet JP.
Title Signalling through the high-affinity IgE receptor Fc epsilonRI.
Journal Reference Authors Gilfillan AM, Tkaczyk C.
Title Integrated signalling pathways for mast-cell activation.
Journal Reference Authors Nadler MJ, Matthews SA, Turner H, Kinet JP.
Title Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Journal Reference Authors Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Title Essential role for Gab2 in the allergic response.
Journal Reference Authors Nadler MJ, Kinet JP.
Title Uncovering new complexities in mast cell signaling.
Journal Related lve04070 Phosphatidylinositol signaling system
KO pathway LinkDB All DBs
