KEGG   PATHWAY: lve04010
Entry
lve04010                    Pathway                                
Name
MAPK signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
lve04010  MAPK signaling pathway
lve04010

Other DBs
GO: 0000165
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068318  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
103068442  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
103068473  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103068522  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103068554  AREG; amphiregulin isoform X1 [KO:K09782]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103068734  NRAS; GTPase NRas [KO:K07828]
103068812  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103069000  STMN1; stathmin isoform X1 [KO:K04381]
103069069  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103069074  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
103069136  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103069139  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
103069161  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103069204  EREG; proepiregulin [KO:K09784]
103069239  RAP1A; ras-related protein Rap-1A [KO:K04353]
103069327  FGF5; fibroblast growth factor 5 [KO:K04358]
103069562  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
103069563  EFNA2; ephrin-A2 [KO:K05462]
103069566  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
103069787  [KO:K04360] [EC:2.7.10.1]
103069814  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
103069902  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103070068  RASA1; ras GTPase-activating protein 1 [KO:K04352]
103070069  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
103070103  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103070268  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103070441  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103070526  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103070557  EFNA1; ephrin-A1 [KO:K05462]
103070633  FLNA; filamin-A isoform X1 [KO:K04437]
103070662  RRAS; ras-related protein R-Ras [KO:K07829]
103070705  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
103070759  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
103070826  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
103070834  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
103070949  CACNB1; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
103071003  MAPK8IP3; c-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
103071458  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
103071473  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103071477  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
103071570  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
103071756  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
103071861  JUN; transcription factor AP-1 [KO:K04448]
103071879  FGF18; fibroblast growth factor 18 [KO:K04358]
103071909  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103071944  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
103071954  TGFBR1; LOW QUALITY PROTEIN: TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103072304  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
103072433  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
103072461  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103072490  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
103072575  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
103072653  NF1; neurofibromin isoform X1 [KO:K08052]
103072843  ARRB1; beta-arrestin-1 [KO:K04439]
103072869  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103072956  [KO:K04379]
103072981  FGF16; fibroblast growth factor 16 [KO:K04358]
103073028  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103073066  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103073201  MAP3K13; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
103073396  MAPK8IP2; c-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
103073411  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
103073501  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103073518  [KO:K03283]
103073618  DUSP10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103073636  MAX; protein max isoform X1 [KO:K04453]
103073774  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103073792  [KO:K03283]
103073819  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103073883  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103073987  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103074069  HSPA1L; LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
103074112  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103074326  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103074334  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103074358  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103074388  FGF23; fibroblast growth factor 23 [KO:K22428]
103074544  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103074827  VEGFC; vascular endothelial growth factor C [KO:K05449]
103074840  [KO:K03283]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103075247  NTF3; neurotrophin-3 [KO:K04356]
103075265  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103075340  MAP3K7; mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
103075402  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103075622  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
103075672  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103075844  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
103075846  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
103075969  ANGPT2; angiopoietin-2 [KO:K05466]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103076085  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
103076122  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
103076318  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
103076342  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076387  PDGFC; platelet-derived growth factor C [KO:K05450]
103076487  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
103076541  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103076636  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103076750  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103076968  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103076982  TGFA; protransforming growth factor alpha [KO:K08774]
103077067  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
103077071  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
103077265  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
103077422  FGF6; fibroblast growth factor 6 [KO:K04358]
103077464  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103077530  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103077552  PSPN; persephin [KO:K25416]
103077579  KRAS; GTPase KRas [KO:K07827]
103077803  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103077870  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
103077876  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103077980  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
103078049  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103078201  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
103078212  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
103078286  NRTN; neurturin [KO:K25414]
103078350  ERBB4; receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
103078399  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103078406  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103078502  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
103078586  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
103078710  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103078792  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103078845  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
103078928  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103079072  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103079150  STK4; serine/threonine-protein kinase 4 [KO:K04411]
103079241  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103079256  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103079439  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
103079514  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103079648  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103079692  [KO:K04424] [EC:2.7.11.25]
103079754  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079965  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
103080020  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
103080104  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103080206  EFNA5; ephrin-A5 [KO:K05462]
103080218  HSPA8; LOW QUALITY PROTEIN: heat shock 70kDa protein 8 [KO:K03283]
103080479  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103080643  KITLG; kit ligand isoform X1 [KO:K05461]
103080704  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
103080813  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
103080860  RELB; transcription factor RelB [KO:K09253]
103080866  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103080890  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
103080961  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103081110  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103081170  [KO:K22603]
103081291  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103081325  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
103081641  [KO:K04433] [EC:2.7.12.2]
103081717  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
103081870  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
103081969  FGF21; fibroblast growth factor 21 [KO:K22429]
103082053  PGF; placenta growth factor isoform X1 [KO:K16859]
103082192  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
103082256  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103082363  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103082365  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
103082417  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
103082490  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103082742  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103082798  DUSP8; LOW QUALITY PROTEIN: dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103083140  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103083209  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103083231  TNF; tumor necrosis factor [KO:K03156]
103083306  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103083354  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
103083385  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103083410  SRF; serum response factor [KO:K04378]
103083426  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
103083510  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103083784  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103083844  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103083922  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
103083967  FGF10; fibroblast growth factor 10 [KO:K04358]
103084028  [KO:K04386]
103084128  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103084220  NGF; beta-nerve growth factor [KO:K02582]
103084433  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
103084559  HSPB1; heat shock protein beta-1 [KO:K04455]
103084630  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103084737  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
103084885  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103085046  PDGFD; platelet-derived growth factor D-like isoform X1 [KO:K05450]
103085069  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103085088  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
103085145  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103085446  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
103085622  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103085645  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
103085713  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
103085721  JUND; transcription factor jun-D [KO:K04449]
103085742  INS; insulin [KO:K04526]
103085873  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
103085900  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
103086359  FGF7; fibroblast growth factor 7 [KO:K04358]
103086371  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
103086387  NTF4; neurotrophin-4 [KO:K12457]
103086424  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103086562  TGFB3; transforming growth factor beta-3 [KO:K13377]
103086653  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103086777  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
103086828  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
103087133  FIGF; vascular endothelial growth factor D [KO:K05449]
103087241  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
103087256  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103087313  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103087340  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
103087588  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
103087676  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103087746  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
103087751  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
103087802  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103087905  CRK; adapter molecule crk isoform X1 [KO:K04438]
103087915  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103087986  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103088020  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
103088140  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5-like [KO:K04463] [EC:2.7.12.2]
103088182  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103088205  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103088257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103088294  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103088460  MAPK8IP1; c-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
103088485  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103088738  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103088795  [KO:K03175] [EC:2.3.2.27]
103088928  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
103088976  [KO:K07836]
103089070  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103089071  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103089095  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
103089110  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
103089216  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103089447  DUSP9; LOW QUALITY PROTEIN: dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
103089479  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
103089656  [KO:K17534] [EC:2.7.11.25]
103089756  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103089793  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103089875  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103089902  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
103089907  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
103089962  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103090018  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103090085  FGF4; fibroblast growth factor 4 [KO:K04358]
103090095  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103090247  IL1A; interleukin-1 alpha [KO:K04383]
103090402  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
103090427  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103090463  CRKL; crk-like protein [KO:K04438]
103090480  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103090482  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103090549  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103090575  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103090681  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103090694  ANGPT4; angiopoietin-4 [KO:K05467]
103090714  ARTN; artemin [KO:K25415]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103090784  IL1B; interleukin-1 beta [KO:K04519]
103090812  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103090898  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103090934  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
103090937  DAXX; death domain-associated protein 6 [KO:K02308]
103090977  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103090984  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
103091027  FGF20; fibroblast growth factor 20 [KO:K04358]
103091045  FGF9; fibroblast growth factor 9 [KO:K04358]
103091203  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103091499  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103091506  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
103091611  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103091628  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
lve04070  Phosphatidylinositol signaling system
lve04110  Cell cycle
lve04115  p53 signaling pathway
lve04210  Apoptosis
lve04310  Wnt signaling pathway
lve04668  TNF signaling pathway
KO pathway
ko04010   

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