KEGG   PATHWAY: mlf04972
Entry
mlf04972                    Pathway                                
Name
Pancreatic secretion - Myotis lucifugus (little brown bat)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
mlf04972  Pancreatic secretion
mlf04972

Other DBs
GO: 0030157
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102431423  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102417971  CCK; cholecystokinin [KO:K05226]
102440710  CCKAR; cholecystokinin receptor type A [KO:K04194]
102424688  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102432706  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102438291  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102432440  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102429686  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102441813  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102428240  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102419083  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
102417248  RAB3D; ras-related protein Rab-3D isoform X1 [KO:K07884]
102437221  RAB8A; ras-related protein Rab-8A [KO:K07901]
102422199  RAB11A; ras-related protein Rab-11A isoform X1 [KO:K07904]
102438698  RAB27B; ras-related protein Rab-27B isoform X1 [KO:K07886]
102418362  RAP1A; ras-related protein Rap-1A [KO:K04353]
102441232  RAP1B; ras-related protein Rap-1b [KO:K07836]
102422264  RHOA; transforming protein RhoA [KO:K04513]
102430746  transforming protein RhoA-like isoform X1 [KO:K04513]
102435667  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102438242  pancreatic alpha-amylase [KO:K01176] [EC:3.2.1.1]
102426099  cationic trypsin-3 [KO:K01312] [EC:3.4.21.4]
102426413  anionic trypsin [KO:K01312] [EC:3.4.21.4]
102427040  anionic trypsin-like [KO:K01312] [EC:3.4.21.4]
102438386  CTRB1; chymotrypsinogen B [KO:K01310] [EC:3.4.21.1]
102422511  CTRL; chymotrypsin-like protease CTRL-1 isoform X1 [KO:K09632] [EC:3.4.21.-]
102427918  chymotrypsin-like elastase family member 2A [KO:K01346] [EC:3.4.21.71]
102438424  CELA3B; chymotrypsin-like elastase family member 3B [KO:K01345] [EC:3.4.21.70]
102418649  CPA1; carboxypeptidase A1 [KO:K08779] [EC:3.4.17.1]
102419807  CPA2; carboxypeptidase A2 [KO:K01298] [EC:3.4.17.15]
102419383  CPA3; mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
102419077  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
102429248  CPB2; carboxypeptidase B2 isoform X1 [KO:K01300] [EC:3.4.17.20]
102434164  pancreatic triacylglycerol lipase [KO:K14073] [EC:3.1.1.3]
102434478  PNLIPRP1; inactive pancreatic lipase-related protein 1 [KO:K14074] [EC:3.1.1.3]
111825871  pancreatic lipase-related protein 2-like [KO:K14075] [EC:3.1.1.3]
102435411  pancreatic lipase-related protein 2-like [KO:K14075] [EC:3.1.1.3]
102435717  pancreatic lipase-related protein 2-like [KO:K14075] [EC:3.1.1.3]
102436035  pancreatic lipase-related protein 2-like [KO:K14075] [EC:3.1.1.3]
102436647  pancreatic lipase-related protein 2-like isoform X1 [KO:K14075] [EC:3.1.1.3]
102425654  pancreatic lipase-related protein 2-like [KO:K14075] [EC:3.1.1.3]
102436335  pancreatic lipase-related protein 2-like [KO:K14075] [EC:3.1.1.3]
102435101  pancreatic lipase-related protein 2-like [KO:K14075] [EC:3.1.1.3]
102416858  pancreatic lipase-related protein 2-like [KO:K14075] [EC:3.1.1.3]
102431153  LOW QUALITY PROTEIN: bile salt-activated lipase-like [KO:K12298] [EC:3.1.1.13 3.1.1.3]
102442628  bile salt-activated lipase isoform X1 [KO:K12298] [EC:3.1.1.13 3.1.1.3]
102418309  bile salt-activated lipase-like [KO:K12298] [EC:3.1.1.13 3.1.1.3]
102431173  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102427978  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102428297  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102417707  phospholipase A2, membrane associated-like isoform X2 [KO:K01047] [EC:3.1.1.4]
102427359  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102431800  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102429635  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102430532  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102427659  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
102427037  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
102427352  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
102419823  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
102441692  PLA2G3; LOW QUALITY PROTEIN: group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102425307  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102422734  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102442861  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102433630  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
102434861  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102437542  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
102425694  TPCN2; LOW QUALITY PROTEIN: two pore calcium channel protein 2 [KO:K14077]
102438797  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
102434429  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
102431228  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102427976  calcium-activated chloride channel regulator 1 [KO:K05027]
102428295  calcium-activated chloride channel regulator 2 isoform X1 [KO:K05028]
102432967  calcium-activated chloride channel regulator 1-like [KO:K05030]
102433283  CLCA4; calcium-activated chloride channel regulator 4 [KO:K05030]
102433592  calcium-activated chloride channel regulator 4 [KO:K05030]
102441488  TRPC1; short transient receptor potential channel 1 [KO:K04964]
102438553  SLC12A2; LOW QUALITY PROTEIN: solute carrier family 12 member 2 [KO:K10951]
102441641  sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
102417711  LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-2-like [KO:K01539] [EC:7.2.2.13]
102429118  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
102432129  ATP1A1; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
102420715  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
102442187  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
102422636  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X3 [KO:K01540]
102428886  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
102423315  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
102437577  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
102422084  KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X6 [KO:K04936]
102422638  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
102418820  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X3 [KO:K05850] [EC:7.2.2.10]
102419529  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X6 [KO:K05850] [EC:7.2.2.10]
102426795  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
102424413  plasma membrane calcium-transporting ATPase 4-like [KO:K05850] [EC:7.2.2.10]
102436075  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
102432248  SLC4A2; anion exchange protein 2 [KO:K13855]
102423916  SCTR; secretin receptor [KO:K04588]
102428502  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X11 [KO:K04632]
102433989  neuroendocrine secretory protein 55-like [KO:K04632]
102430354  ADCY2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
102442682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102417969  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102425254  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102433159  ADCY6; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102423495  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102422477  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102419125  CFTR; cystic fibrosis transmembrane conductance regulator isoform X2 [KO:K05031] [EC:5.6.1.6]
102439079  SLC26A3; chloride anion exchanger [KO:K14078]
102433901  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 [KO:K13575]
102436958  carbonic anhydrase 2-like [KO:K18245] [EC:4.2.1.1]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
mlf04020  Calcium signaling pathway
mlf04530  Tight junction
mlf04973  Carbohydrate digestion and absorption
mlf04974  Protein digestion and absorption
mlf04975  Fat digestion and absorption
mlf04977  Vitamin digestion and absorption
KO pathway
ko04972   
LinkDB

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