KEGG   PATHWAY: mlf04020
Entry
mlf04020                    Pathway                                
Name
Calcium signaling pathway - Myotis lucifugus (little brown bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mlf04020  Calcium signaling pathway
mlf04020

Other DBs
GO: 0019722
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102417974  SLC8A1; LOW QUALITY PROTEIN: sodium/calcium exchanger 1 [KO:K05849]
102439868  SLC8A3; sodium/calcium exchanger 3 [KO:K05849]
102422638  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
102418820  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X3 [KO:K05850] [EC:7.2.2.10]
102419529  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X6 [KO:K05850] [EC:7.2.2.10]
102426795  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
102424413  plasma membrane calcium-transporting ATPase 4-like [KO:K05850] [EC:7.2.2.10]
102431423  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102432519  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102436564  ADORA2A; adenosine receptor A2a [KO:K04266]
102439466  ADORA2B; adenosine receptor A2b [KO:K04267]
102437112  ADRB2; beta-2 adrenergic receptor [KO:K04142]
102434895  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
102427259  DRD1; D(1A) dopamine receptor [KO:K04144]
102423058  D(1B) dopamine receptor [KO:K05840]
102440103  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
102437422  HTR4; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 4 [KO:K04160]
102421217  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
102422303  5-hydroxytryptamine receptor 7-like [KO:K04163]
102428502  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X11 [KO:K04632]
102433989  neuroendocrine secretory protein 55-like [KO:K04632]
102428060  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
102430354  ADCY2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
102442682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102417969  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102423495  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102422477  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102437773  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102417960  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102424805  PLN; cardiac phospholamban [KO:K05852]
102437040  SLN; sarcolipin [KO:K22642]
102439534  MRLN; myoregulin [KO:K22643]
102427387  SMIM6; small integral membrane protein 6 [KO:K26468]
102438797  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
102434429  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
102431228  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102422391  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
102439554  STIM2; stromal interaction molecule 2 isoform X2 [KO:K18196]
102418943  ORAI1; LOW QUALITY PROTEIN: calcium release-activated calcium channel protein 1 [KO:K16056]
102441100  ORAI2; protein orai-2 isoform X1 [KO:K16057]
102424719  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102420982  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102434312  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
102423622  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102418865  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102425815  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
102432804  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
102440836  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102436175  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
102433108  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102430817  GRIN3A; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3A [KO:K05213]
102425604  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
102438494  P2RX1; P2X purinoceptor 1 [KO:K05215]
102441703  P2RX2; P2X purinoceptor 2 [KO:K05216]
102433161  P2RX3; P2X purinoceptor 3 [KO:K05217]
102422146  P2RX4; P2X purinoceptor 4 isoform X4 [KO:K05218]
102423653  P2RX5; P2X purinoceptor 5 [KO:K05219]
102422022  P2RX6; P2X purinoceptor 6 [KO:K05221]
102422647  P2RX7; P2X purinoceptor 7 isoform X2 [KO:K05220]
102437305  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
102433630  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
102429678  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
102431991  TRDN; triadin [KO:K23449]
102441961  CASQ1; calsequestrin-1 [KO:K23468]
102420101  calsequestrin-2 [KO:K23445]
102442781  calsequestrin-2 [KO:K23445]
102438511  splicing regulatory glutamine/lysine-rich protein 1-like [KO:K00476] [EC:1.14.11.16]
102418625  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X8 [KO:K00476] [EC:1.14.11.16]
102417231  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
102436620  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X2 [KO:K04323]
102431567  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102434728  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
102435324  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
102442270  ADRA1D; LOW QUALITY PROTEIN: alpha-1D adrenergic receptor [KO:K04137]
102418550  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102437634  EDNRA; endothelin-1 receptor [KO:K04197]
102436123  EDNRB; endothelin receptor type B [KO:K04198]
102421923  F2R; proteinase-activated receptor 1 [KO:K03914]
102428336  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
102418574  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
102417702  GRPR; gastrin-releasing peptide receptor [KO:K04169]
102439287  HRH1; histamine H1 receptor [KO:K04149]
102432483  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
102433399  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
102428115  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
102435177  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
102430568  OXTR; oxytocin receptor [KO:K04229]
102421909  AVPR1A; vasopressin V1a receptor [KO:K04226]
102426619  AVPR1B; vasopressin V1b receptor [KO:K04227]
102419035  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
102427767  PTAFR; platelet-activating factor receptor [KO:K04279]
102420060  PTGER1; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP1 subtype [KO:K04258]
102442487  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
102433435  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
102425270  BDKRB1; LOW QUALITY PROTEIN: B1 bradykinin receptor [KO:K03915]
102424220  BDKRB2; B2 bradykinin receptor [KO:K03916]
102423641  TACR1; substance-P receptor [KO:K04222]
102440739  TACR2; substance-K receptor [KO:K04223]
102421498  TACR3; neuromedin-K receptor [KO:K04224]
102426051  TBXA2R; LOW QUALITY PROTEIN: thromboxane A2 receptor [KO:K04264]
102440710  CCKAR; cholecystokinin receptor type A [KO:K04194]
102416985  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
102427675  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102424688  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102424028  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102424377  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X2 [KO:K04636]
102436920  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
102424256  EGF; pro-epidermal growth factor [KO:K04357]
102434624  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
102422469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102426780  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102442814  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102418575  PDGFD; platelet-derived growth factor D [KO:K05450]
102431344  FGF1; fibroblast growth factor 1 [KO:K18496]
111825710  FGF2; fibroblast growth factor 2 [KO:K18497]
102420818  FGF16; fibroblast growth factor 16 [KO:K04358]
102438838  FGF10; fibroblast growth factor 10 [KO:K04358]
102421786  FGF6; fibroblast growth factor 6 [KO:K04358]
102422136  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102432454  FGF20; fibroblast growth factor 20 [KO:K04358]
102442835  FGF9; fibroblast growth factor 9 [KO:K04358]
102426314  FGF4; fibroblast growth factor 4 [KO:K04358]
102428863  FGF7; fibroblast growth factor 7 [KO:K04358]
102428528  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102429928  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
102426634  FGF3; fibroblast growth factor 3 [KO:K04358]
102440432  FGF18; fibroblast growth factor 18 [KO:K04358]
102426451  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102426004  FGF19; fibroblast growth factor 19 [KO:K22603]
102432520  FGF21; fibroblast growth factor 21 [KO:K22429]
102439118  fibroblast growth factor 21-like [KO:K22429]
102432233  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
102426433  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102438597  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102421161  VEGFD; vascular endothelial growth factor D [KO:K05449]
102438038  VEGFC; vascular endothelial growth factor C [KO:K05449]
102427030  NGF; beta-nerve growth factor [KO:K02582]
102441297  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102431995  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102435209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102427788  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102438329  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
102442922  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102417415  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102441579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102423450  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102419131  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102417951  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102422327  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102430005  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102442473  KDR; vascular endothelial growth factor receptor 2 isoform X3 [KO:K05098] [EC:2.7.10.1]
102431497  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102426842  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102443290  LOW QUALITY PROTEIN: NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
102433411  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
102441042  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102437061  MST1R; LOW QUALITY PROTEIN: macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
102420377  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102431544  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
102437533  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
102422228  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
102432706  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102438291  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102432440  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102429686  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102441813  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102421330  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102420000  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
102427329  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
102418100  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
102422734  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102442861  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102434861  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102430592  TPCN1; two pore calcium channel protein 1 [KO:K16896]
102425694  TPCN2; LOW QUALITY PROTEIN: two pore calcium channel protein 2 [KO:K14077]
102435909  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
102417360  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
102417678  MCOLN3; mucolipin-3 isoform X2 [KO:K04994]
102434379  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
102421251  SPHK1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
102420868  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
102433336  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102431583  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102441962  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102425183  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102423425  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102442613  ADP/ATP translocase 3-like [KO:K05863]
102426982  ADP/ATP translocase 3-like [KO:K05863]
102435956  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102431195  PPIF; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102422482  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
102422286  troponin C, skeletal muscle-like [KO:K12042]
102422790  TNNC2; troponin C, skeletal muscle [KO:K12042]
102430787  CALM2; calmodulin-2 isoform X1 [KO:K02183]
102417912  calmodulin-A-like isoform X1 [KO:K02183]
102419493  calmodulin-like protein 3 [KO:K02183]
102419808  calmodulin-like protein 5 [KO:K02183]
102426645  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102434863  CALM1; calmodulin-1 [KO:K02183]
102440407  calmodulin-like [KO:K02183]
102443136  calmodulin-like [KO:K02183]
102423171  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
102441572  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
102431515  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
102437379  PHKA2; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
102431229  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
102427404  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102443301  MYLK2; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102416877  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102424117  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
102440601  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
102421827  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X2 [KO:K08794] [EC:2.7.11.17]
102428043  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
102427134  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5 [KO:K04515] [EC:2.7.11.17]
102440347  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102433506  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
102434410  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102441003  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102421207  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102430192  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102428803  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102436654  TFEB; transcription factor EB isoform X1 [KO:K15590]
102428507  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102441857  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
102426111  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102417139  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102433074  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
102424107  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
102436714  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
102439889  PDE1B; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
102431768  PDE1C; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
102427182  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
102442091  PTK2B; protein-tyrosine kinase 2-beta isoform X4 [KO:K05871] [EC:2.7.10.2]
102425506  ITPKB; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
102422931  ITPKC; inositol-trisphosphate 3-kinase C isoform X2 [KO:K00911] [EC:2.7.1.127]
102420988  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102428240  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102419083  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
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L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
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Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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PMID:11698232
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
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Reference
PMID:9235901
  Authors
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  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
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Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
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Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
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PMID:14517314
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Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
PMID:19172794
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
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Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mlf04010  MAPK signaling pathway
mlf04070  Phosphatidylinositol signaling system
mlf04210  Apoptosis
mlf04720  Long-term potentiation
mlf04730  Long-term depression
KO pathway
ko04020   
LinkDB

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