KEGG   PATHWAY: mmf04144
Entry
mmf04144                    Pathway                                
Name
Endocytosis - Molossus molossus (Pallas's mastiff bat)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
mmf04144  Endocytosis
mmf04144

Other DBs
GO: 0006897
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118638290  ARF6; ADP-ribosylation factor 6 [KO:K07941]
118629413  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
118636949  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
118643601  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
118630228  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
118633939  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
118617100  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
118629454  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
118637128  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
118615272  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
118629565  CLTA; clathrin light chain A isoform X1 [KO:K04644]
118616255  CLTB; clathrin light chain B isoform X1 [KO:K04645]
118635039  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
118643182  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
118639450  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
118635047  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
118617203  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
118638928  AP2S1; AP-2 complex subunit sigma [KO:K11827]
118639473  EHD2; EH domain-containing protein 2 [KO:K12469]
118629403  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
118633307  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118625997  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
118641786  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
118627567  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
118618734  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
118638472  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
118616858  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
118620077  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118624129  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118632260  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118633856  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118643683  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118640813  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
118628368  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
118617083  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
118638889  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
118635958  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
118640991  SH3GL3; endophilin-A3 [KO:K11247]
118629633  SH3GL2; endophilin-A1 [KO:K11247]
118615140  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
118626329  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
118629658  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
118620326  AMPH; amphiphysin isoform X1 [KO:K12562]
118625223  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
118641273  EPN2; epsin-2 isoform X1 [KO:K12471]
118634948  EPN3; epsin-3 isoform X1 [KO:K12471]
118639181  EPN1; LOW QUALITY PROTEIN: epsin-1 [KO:K12471]
118626586  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
118643566  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
118622999  SPART; spartin [KO:K19366]
118630785  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
118618257  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
118623649  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118628151  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
118624473  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
118619138  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
118633915  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
118643609  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
118631398  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
118615655  LDLR; low-density lipoprotein receptor [KO:K12473]
118626635  LDLRAP1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
118642801  DAB2; disabled homolog 2 [KO:K12475]
118633424  C-C chemokine receptor type 5-like [KO:K04180]
118625201  C-X-C chemokine receptor type 2-like [KO:K05050]
118625406  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
118633542  GRK7; LOW QUALITY PROTEIN: rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
118622775  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
118639875  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
118627698  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
118643634  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
118632060  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
118638950  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
118634043  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
118627946  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
118619836  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
118630616  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
118620002  ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
118624975  ACTR3; actin-related protein 3 [KO:K18584]
118641757  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
118641961  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
118635289  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2-like [KO:K05758]
118637223  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2-like [KO:K05758]
118625144  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
118640245  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
118615988  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
118633033  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
118635357  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
118629871  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
118637571  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
118634085  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
118620064  WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
118623694  synapsin-1-like [KO:K19475]
118625168  WIPF1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
118639973  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
118621036  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
118621339  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
118621340  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
118627194  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
118623454  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
118631491  WASHC5; WASH complex subunit 5 [KO:K18464]
118632045  WASH complex subunit 2-like isoform X1 [KO:K18462]
118624006  WASHC1; WASH complex subunit 1 [KO:K18461]
118624013  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
118619877  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
118620081  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1-like [KO:K10364]
118636918  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
118624538  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
118626495  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
118640242  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
118640193  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
118632399  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
118638517  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
118636481  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
118621862  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
118632907  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
118631037  STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
118618120  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
118634370  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
118638465  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
118625457  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
118628221  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
118629632  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
118615696  MVB12A; multivesicular body subunit 12A [KO:K12186]
118643280  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
118640154  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
118629044  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
118642606  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
118622836  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
118633814  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
118622571  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
118634281  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
118634383  CHMP6; charged multivesicular body protein 6 [KO:K12195]
118618323  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
118627796  CHMP4A; LOW QUALITY PROTEIN: charged multivesicular body protein 4a [KO:K12194]
118631645  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
118630620  CHMP3; charged multivesicular body protein 3 [KO:K12193]
118638230  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
118617688  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
118616218  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
118618778  VPS4B; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
118639229  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
118621184  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
118631369  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
118618222  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
118636201  charged multivesicular body protein 1b-2 isoform X1 [KO:K12197]
118632569  charged multivesicular body protein 1b-2-like [KO:K12197]
118639414  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
118629537  CHMP5; charged multivesicular body protein 5 [KO:K12198]
118639077  IST1 homolog [KO:K19476]
118639392  IST1; IST1 homolog isoform X1 [KO:K19476]
118633030  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
118635778  SPG21; maspardin [KO:K19367]
118620944  IGF2R; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
118641626  SNX2; sorting nexin-2 [KO:K17917]
118632321  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
118618268  SNX5; sorting nexin-5 [KO:K17920]
118628746  SNX32; LOW QUALITY PROTEIN: sorting nexin-32 [KO:K17920]
118643360  SNX6; sorting nexin-6 [KO:K17920]
118618720  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118632297  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
118624074  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
118635917  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
118632939  RHOA; transforming protein RhoA [KO:K04513]
118621148  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
118621233  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
118639188  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118639189  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118627690  folate receptor beta-like [KO:K13649]
118627691  folate receptor beta-like [KO:K13649]
118627692  folate receptor alpha-like [KO:K13649]
118627693  folate receptor alpha-like isoform X1 [KO:K13649]
118620482  CAV1; caveolin-1 isoform X1 [KO:K06278]
118619898  CAV2; caveolin-2 [KO:K12958]
118633298  CAV3; caveolin-3 [KO:K12959]
118630685  EHD3; EH domain-containing protein 3 [KO:K12476]
118638396  EHD4; EH domain-containing protein 4 [KO:K12477]
118624186  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
118633623  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
118623493  RAB5B; ras-related protein Rab-5B [KO:K07888]
118634576  RAB5C; ras-related protein Rab-5C [KO:K07889]
118633879  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
118633238  RBSN; rabenosyn-5 [KO:K12481]
118640674  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
118632592  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
118615704  RUFY1; RUN and FYVE domain-containing protein 1 [KO:K12482]
118627602  EHD1; EH domain-containing protein 1 [KO:K12483]
118638001  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
118617860  SNX4; sorting nexin-4 [KO:K17919]
118618237  RAB31; ras-related protein Rab-31 isoform X1 [KO:K07891]
118618772  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
118630495  RAB10; ras-related protein Rab-10 isoform X1 [KO:K07903]
118615433  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
118639789  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
118640930  RAB11A; ras-related protein Rab-11A [KO:K07904]
118615299  RAB11B; ras-related protein Rab-11B isoform X1 [KO:K07905]
118622505  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
118630766  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
118632442  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
118632040  ZFYVE27; protrudin isoform X1 [KO:K19368]
118625741  KIF5C; kinesin heavy chain [KO:K10396]
118624249  KIF5A; kinesin heavy chain [KO:K10396]
118624582  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
118634717  RAB11FIP4; rab11 family-interacting protein 4 [KO:K12485]
118642539  RAB11FIP3; rab11 family-interacting protein 3 [KO:K12485]
118616553  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
118618742  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
118619358  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
118638707  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
118643394  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
118617164  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
118626070  CDC42; cell division control protein 42 homolog [KO:K04393]
118638912  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
118627143  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
118620941  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
118634363  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
118640261  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
118626341  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
118630748  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
118631397  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
118617411  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
118634491  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
118643412  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
118628024  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
118618782  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
118615668  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
118625477  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
118620109  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
118623857  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
118618901  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
118627651  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
118624497  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
118622270  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
118630640  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
118615868  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
118632004  PSD; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
118635953  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
118624499  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
118617055  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
118634828  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
118623471  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
118615723  CYTH3; cytohesin-3 [KO:K18441]
118639380  CYTH2; cytohesin-2 [KO:K18441]
118618216  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
118631781  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
118632540  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
118621410  ADP-ribosylation factor 1-like [KO:K07937]
118615148  ARF1; ADP-ribosylation factor 1 [KO:K07937]
118623963  ARF3; ADP-ribosylation factor 3 [KO:K07938]
118633143  ARF4; ADP-ribosylation factor 4 isoform X1 [KO:K07939]
118619962  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
mmf04060  Cytokine-cytokine receptor interaction
mmf04070  Phosphatidylinositol signaling system
mmf04130  SNARE interactions in vesicular transport
mmf04142  Lysosome
mmf04350  TGF-beta signaling pathway
KO pathway
ko04144   
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