KEGG   PATHWAY: mmyo04150
Entry
mmyo04150                   Pathway                                
Name
mTOR signaling pathway - Myotis myotis (greater mouse-eared bat)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmyo04150  mTOR signaling pathway
mmyo04150

Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118673982  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
118648994  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
118656312  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
118676142  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
118657996  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
118668877  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
118669278  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
118670702  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
118656775  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
118650310  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
118669485  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
118666428  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
118666304  V-type proton ATPase subunit G 1-like [KO:K02152]
118678759  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
118667098  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
118667222  V-type proton ATPase subunit G 1-like [KO:K02152]
118679590  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
118670820  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
118664705  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
118673568  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
118656274  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
118673597  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
118649349  FLCN; folliculin isoform X1 [KO:K09594]
118657767  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
118659159  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
118667574  RRAGA; ras-related GTP-binding protein A [KO:K16185]
118654023  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
118660300  RRAGD; ras-related GTP-binding protein D [KO:K16186]
118675195  RRAGC; ras-related GTP-binding protein C [KO:K16186]
118676292  SESN2; sestrin-2 isoform X1 [KO:K20394]
118678305  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
118656127  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
118666187  MIOS; GATOR complex protein MIOS [KO:K20407]
118662575  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
118652927  WDR24; GATOR complex protein WDR24 [KO:K20408]
118674427  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
118668058  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
118678463  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
118668445  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
118652864  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
118655860  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
118663260  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
118671632  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
118655365  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
118675322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118670778  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
118656155  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
118656079  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
118662426  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
118678645  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
118665898  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
118669270  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
118663294  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
118663520  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
118653012  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
118649389  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
118651220  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118661256  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
118671661  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
118657632  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
118649569  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
118649570  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
118671643  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118665219  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
118649810  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
118678902  40S ribosomal protein S6 [KO:K02991]
118667577  RPS6; 40S ribosomal protein S6 [KO:K02991]
118675992  40S ribosomal protein S6 [KO:K02991]
118676503  40S ribosomal protein S6-like [KO:K02991]
118671608  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
118661728  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
118659345  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
118650817  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
118661387  CAB39; calcium-binding protein 39 isoform X1 [KO:K08272]
118656158  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118677140  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
118666926  TSC1; hamartin isoform X1 [KO:K07206]
118656215  TSC2; tuberin isoform X1 [KO:K07207]
118676753  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
118651521  GTP-binding protein Rheb [KO:K07208]
118679434  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
118670126  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
118650977  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118672911  WNT2B; protein Wnt-2b [KO:K00182]
118666478  WNT2; protein Wnt-2 [KO:K00182]
118658755  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
118672219  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
118676694  WNT4; protein Wnt-4 [KO:K00408]
118650248  WNT5B; protein Wnt-5b [KO:K00444]
118667971  WNT5A; protein Wnt-5a [KO:K00444]
118662211  WNT6; protein Wnt-6 [KO:K00445]
118650243  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
118677354  WNT7A; protein Wnt-7a [KO:K00572]
118658912  WNT8A; protein Wnt-8a [KO:K00714]
118669850  WNT8B; protein Wnt-8b [KO:K00714]
118658374  WNT9A; protein Wnt-9a [KO:K01064]
118671436  WNT9B; protein Wnt-9b [KO:K01064]
118651671  WNT10B; protein Wnt-10b [KO:K01357]
118661959  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
118664619  WNT11; protein Wnt-11 [KO:K01384]
118666468  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
118666245  FZD1; frizzled-1 [KO:K02432]
118661773  FZD7; frizzled-7 [KO:K02432]
118672294  FZD2; frizzled-2 [KO:K02235]
118658774  FZD3; frizzled-3 isoform X1 [KO:K02329]
118664546  FZD4; frizzled-4 [KO:K02354]
118661425  FZD5; frizzled-5 [KO:K02375]
118676314  FZD8; frizzled-8 [KO:K02375]
118670703  FZD6; frizzled-6 [KO:K02376]
118653033  FZD10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
118656623  FZD9; frizzled-9 [KO:K02842]
118649950  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
118665196  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
118677642  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
118655561  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
118672041  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118675932  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118679652  tumor necrosis factor-like isoform X1 [KO:K03156]
118649937  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118650776  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118659596  insulin-like [KO:K04526]
118659608  insulin-like [KO:K04526]
118659612  insulin-like [KO:K04526]
118651145  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118659286  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118679204  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118671153  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
118669078  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118654741  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118648965  HRAS; GTPase HRas isoform X1 [KO:K02833]
118649554  KRAS; GTPase KRas isoform X1 [KO:K07827]
118672986  NRAS; GTPase NRas [KO:K07828]
118666337  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118668076  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118654213  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118657986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
118678650  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118656605  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118660397  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118653707  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118654110  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
118675865  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118661524  IRS1; insulin receptor substrate 1 [KO:K16172]
118675217  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118656203  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118657573  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118677590  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118668125  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675045  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118677363  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118670001  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118656443  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118678909  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118655031  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118674834  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118669852  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118667056  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
118655721  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
118650110  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
118665128  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
118668483  RHOA; transforming protein RhoA [KO:K04513]
118664539  transforming protein RhoA-like isoform X1 [KO:K04513]
118671569  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118655815  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118660957  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118660084  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mmyo00561  Glycerolipid metabolism
mmyo04010  MAPK signaling pathway
mmyo04140  Autophagy - animal
mmyo04151  PI3K-Akt signaling pathway
mmyo04152  AMPK signaling pathway
mmyo04810  Regulation of actin cytoskeleton
mmyo04910  Insulin signaling pathway
KO pathway
ko04150   
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