KEGG   PATHWAY: nsu04727
Entry
nsu04727                    Pathway                                
Name
GABAergic synapse - Neomonachus schauinslandi (Hawaiian monk seal)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
nsu04727  GABAergic synapse
nsu04727

Other DBs
GO: 0051932
Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110593544  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
110593650  SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
110592139  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
110577823  GLS2; glutaminase liver isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
110591817  GAD1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
110577735  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
110579560  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
110587863  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
110590812  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
110574742  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
110590820  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
110572227  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
110587814  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
110587825  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
110590825  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
110572230  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
110587790  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
110590828  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
110572226  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
110587836  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
110574608  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
110574731  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
110574811  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
110590421  gamma-aminobutyric acid receptor subunit pi [KO:K05189]
110580659  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
110594123  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110579592  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
110570410  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110577506  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
110573626  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110573276  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
110581097  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
110584690  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
110594214  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
110570452  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
110592386  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
110592125  PLCL1; LOW QUALITY PROTEIN: inactive phospholipase C-like protein 1 [KO:K15375]
110571712  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
110579531  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
110583356  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
110583387  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
110578428  GABRR3; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
110593832  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
110581302  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
110581023  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110584803  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110570742  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
110573862  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110581722  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
110586628  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
110579950  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
110580654  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
110577535  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
110594277  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
110575102  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110571879  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110581074  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110582429  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
110583964  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110590624  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
110575905  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110586041  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110590844  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
110580660  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110575312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
110593950  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110572795  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110588574  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
110581444  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110582181  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
110580003  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110583870  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
110587626  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
110588681  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
110571845  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110588033  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123323680  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110579839  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
110592985  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
110592662  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110591563  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110587205  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
110585498  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110582647  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110593651  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
110593510  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
110578940  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
110588085  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
110569994  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
110584847  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
110580880  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
110584795  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
110580837  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
110574111  GLUL; glutamine synthetase isoform X2 [KO:K01915] [EC:6.3.1.2]
110577627  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
110570993  SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
nsu00020  Citrate cycle (TCA cycle)
nsu00250  Alanine, aspartate and glutamate metabolism
nsu04144  Endocytosis
nsu04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

DBGET integrated database retrieval system