KEGG   PATHWAY: one04914
Entry
one04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Oncorhynchus nerka (sockeye salmon)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
one04914  Progesterone-mediated oocyte maturation
one04914

Other DBs
GO: 0001556
Organism
Oncorhynchus nerka (sockeye salmon) [GN:one]
Gene
115112007  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
115121421  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
115145315  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115108180  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115114221  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115125089  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115114621  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115102907  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115109150  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115147159  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115103245  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115141974  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
115136609  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
115114142  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115132207  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115108455  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115103316  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115128757  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
115135343  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115119601  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
115130519  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115106409  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115144005  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115113414  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115146824  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115135470  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115105636  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115143529  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115107039  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115107040  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
115132056  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
115132526  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115133058  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115133059  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115102640  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115102646  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
115134093  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115109568  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115142360  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
115136153  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
115143141  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
115143191  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
115132538  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
115132987  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
115139615  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
115126262  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
115140088  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
115134127  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
115109538  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
115114521  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
115102992  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
115128595  LOW QUALITY PROTEIN: adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
115106654  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
115139332  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
115141418  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
115131798  adenylate cyclase type 2-like [KO:K08044] [EC:4.6.1.1]
115110765  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
115130118  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
115131919  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
115102673  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
115112487  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
115113769  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
115123485  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
115114051  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
115104341  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115114535  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115139544  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115102979  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
115143513  aurora kinase C-like [KO:K11481] [EC:2.7.11.1]
115135277  cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602]
115118555  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
115105240  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
115113356  cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602]
115145100  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
115124723  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
115108507  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
115116842  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
115134570  cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
115102808  spdya; speedy protein A [KO:K08694]
115143073  cyclin-dependent kinase 2-like isoform X1 [KO:K02206] [EC:2.7.11.22]
115141071  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
115135037  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115113171  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115129565  cyclin-A2-like [KO:K06627]
115130831  cyclin-A2-like [KO:K06627]
115123810  cyclin-A1-like isoform X1 [KO:K06627]
115131101  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
115118567  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
115107603  heat shock protein HSP 90-beta-like [KO:K04079]
115107965  heat shock protein HSP 90-alpha [KO:K04079]
115107966  heat shock protein HSP 90-alpha 1-like [KO:K04079]
115139654  heat shock protein HSP 90-beta [KO:K04079]
115145247  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115110004  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115135547  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
115104977  ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
115130107  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
115113027  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
115138283  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
115144420  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
115101413  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
115146431  ribosomal protein S6 kinase 2 alpha-like isoform X1 [KO:K04373] [EC:2.7.11.1]
115106713  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
115112810  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115122380  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115101145  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
115136595  cntd2; cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
115112265  G2/mitotic-specific cyclin-B2-like [KO:K21770]
115113650  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
115123879  G2/mitotic-specific cyclin-B3-like [KO:K21771]
115105266  serine/threonine-protein kinase 10-like [KO:K08837] [EC:2.7.11.1]
115136202  serine/threonine-protein kinase 10-like [KO:K08837] [EC:2.7.11.1]
115123289  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
115127183  M-phase inducer phosphatase 2-like isoform X1 [KO:K05866] [EC:3.1.3.48]
115101434  cdc25c; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
115104644  insulin [KO:K04526]
115129128  insulin-like [KO:K04526]
115124592  insulin-like [KO:K04526]
115107064  insulin-like growth factor I isoform X1 [KO:K05459]
115133034  insulin-like growth factor I isoform X1 [KO:K05459]
115109402  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115134267  LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115103883  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115135438  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115141982  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115136593  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115144345  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115138454  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115107835  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115139339  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115146263  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115146827  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115103843  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115121140  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like [KO:K13296] [EC:3.1.4.17]
115116666  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
115134119  GTPase KRas isoform X1 [KO:K07827]
115109544  GTPase KRas isoform X1 [KO:K07827]
115111809  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
115140270  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K08845] [EC:2.7.11.1]
115131882  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
115107641  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
115139604  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
115117851  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
115138197  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
115102281  mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
115108443  fizzy-related protein homolog isoform X1 [KO:K03364]
115114618  fizzy-related protein homolog [KO:K03364]
115114731  fizzy-related protein homolog [KO:K03364]
115102714  fizzy-related protein homolog isoform X1 [KO:K03364]
115113138  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
115122414  anaphase-promoting complex subunit 2-like [KO:K03349]
115101147  anaphase-promoting complex subunit 2-like [KO:K03349]
115104026  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
115110129  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
115108517  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
115139946  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
115122393  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
115107463  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
115111484  anaphase-promoting complex subunit 7-like [KO:K03354]
115139916  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
115135522  cell division cycle protein 23 homolog [KO:K03355]
115117325  cell division cycle protein 23 homolog [KO:K03355]
115124807  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
115142580  anaphase-promoting complex subunit 11 [KO:K03358]
115103790  anaphase-promoting complex subunit 11 [KO:K03358]
115121194  anaphase-promoting complex subunit CDC26-like [KO:K03359]
115147168  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
115105425  anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
115141999  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
115122286  anaphase-promoting complex subunit 15-like [KO:K25228]
115119486  anaphase-promoting complex subunit 16-like [KO:K25229]
115120014  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
115106729  kif22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
one04010  MAPK signaling pathway
one04110  Cell cycle
KO pathway
ko04914   
LinkDB

DBGET integrated database retrieval system