KEGG   PATHWAY: pflv04137
Entry
pflv04137                   Pathway                                
Name
Mitophagy - animal - Perca flavescens (yellow perch)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
pflv04137  Mitophagy - animal
pflv04137

Other DBs
GO: 0000422
Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114560402  ambra1; activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
114558462  pink1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
114568237  tomm7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
114566344  mitochondrial import receptor subunit TOM40B-like isoform X1 [KO:K11518]
114568188  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
114557098  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
114570007  mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
114572071  tomm20; mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
114561310  tomm70; mitochondrial import receptor subunit TOM70 [KO:K17768]
114572102  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
114571194  E3 ubiquitin-protein ligase MARCH5-like [KO:K10660] [EC:2.3.2.27]
114572294  march5; E3 ubiquitin-protein ligase MARCH5 [KO:K10660] [EC:2.3.2.27]
114571020  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
114571300  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114555721  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
114569505  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
114569633  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
114571256  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
114557764  amfr; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
114559339  mul1; mitochondrial ubiquitin ligase activator of NFKB 1 [KO:K15688] [EC:2.3.2.27]
114565686  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
114565736  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
114559188  huwe1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
114560246  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
114560643  arih1; E3 ubiquitin-protein ligase ARIH1 [KO:K11968] [EC:2.3.2.31]
114561784  mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
114558679  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
114566442  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
114569371  mitochondrial Rho GTPase 1-A isoform X1 [KO:K07870] [EC:3.6.5.-]
114548235  rhot2; mitochondrial Rho GTPase 2 isoform X1 [KO:K07871] [EC:3.6.5.-]
114561363  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
114572637  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
114567297  ubb; polyubiquitin-B isoform X1 [KO:K04551]
114571049  LOW QUALITY PROTEIN: polyubiquitin-B-like [KO:K04551]
114568014  LOW QUALITY PROTEIN: tax1-binding protein 1 homolog [KO:K21347]
114557195  tax1-binding protein 1 homolog B-like isoform X1 [KO:K21347]
114552016  sqstm1; LOW QUALITY PROTEIN: sequestosome-1 [KO:K14381]
114564760  histone-lysine N-methyltransferase, H3 lysine-79 specific-like [KO:K21348]
114547821  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
114550026  optn; optineurin [KO:K19946]
114570337  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
114548012  nbr1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
114550466  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114553151  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
114545938  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
114560155  gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
114557540  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
114554075  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
114560332  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
114562986  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
114551547  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
114548469  becn1; beclin-1 isoform X1 [KO:K08334]
114556916  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
114549983  usp15; ubiquitin carboxyl-terminal hydrolase 15 isoform X1 [KO:K21343] [EC:3.4.19.12]
114555105  usp30; ubiquitin carboxyl-terminal hydrolase 30 isoform X1 [KO:K11851] [EC:3.4.19.12]
114558681  bcl2l1; bcl-2-like protein 1 [KO:K04570]
114553544  bcl-2-like protein 1 [KO:K04570]
114556367  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
114554486  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
114560513  csnk2a2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
114560559  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
114557682  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
114567914  casein kinase II subunit beta [KO:K03115]
114557284  casein kinase II subunit beta [KO:K03115]
114554227  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
114558328  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114571073  ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
114556418  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
114564535  fundc1; FUN14 domain-containing protein 1 [KO:K17986]
114551162  FUN14 domain-containing protein 1 isoform X1 [KO:K17986]
114571368  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
114572212  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1 [KO:K15464]
114570836  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
114555990  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
114559806  bcl2l13; bcl-2-like protein 13 isoform X1 [KO:K15485]
114559735  peptidyl-prolyl cis-trans isomerase FKBP8-like isoform X1 [KO:K09574] [EC:5.2.1.8]
114562166  fkbp8; peptidyl-prolyl cis-trans isomerase FKBP8 [KO:K09574] [EC:5.2.1.8]
114560225  sorting and assembly machinery component 50 homolog A isoform X1 [KO:K07277]
114550420  samm50; sorting and assembly machinery component 50 homolog [KO:K07277]
114565194  phb2; prohibitin-2 [KO:K17081]
114553169  nlrx1; NLR family member X1 [KO:K12653]
114555312  mtx3; metaxin-3 isoform X1 [KO:K17776]
114571927  mtx2; metaxin-2 [KO:K17776]
114551480  metaxin-1-like [KO:K17776]
114547007  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
114573159  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
114570148  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
114573247  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
114570928  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114547944  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114572302  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
114563046  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
114566085  jun; transcription factor AP-1 [KO:K04448]
114571404  transcription factor AP-1-like [KO:K04448]
114561902  transcription factor AP-1-like [KO:K04448]
114545913  transcription factor p65-like isoform X1 [KO:K04735]
114559784  hras; GTPase HRas [KO:K02833]
114559939  kras; GTPase KRas [KO:K07827]
114569569  GTPase HRas-like [KO:K07827]
114563940  mras; ras-related protein M-Ras [KO:K07831]
114553173  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
114570129  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
114559356  e2f1; transcription factor E2F1 [KO:K17454]
114552735  hypoxia-inducible factor 1-alpha-like [KO:K08268]
114546639  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
114554650  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
114545465  cellular tumor antigen p53-like isoform X1 [KO:K04451]
114567797  forkhead box protein O6-like [KO:K09408]
114573429  foxo3; forkhead box protein O3 [KO:K09408]
114553836  microphthalmia-associated transcription factor-like [KO:K09455]
114558092  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
114553633  transcription factor EB-like isoform X1 [KO:K15590]
114559336  transcription factor E3-like [KO:K09105]
114554869  transcription factor E3-like isoform X1 [KO:K09105]
114552832  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
114567053  rabgef1; rab5 GDP/GTP exchange factor [KO:K20131]
114555578  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
114567838  ras-related protein Rab-5A [KO:K07887]
114556504  rab5a; ras-related protein Rab-5A [KO:K07887]
114564094  ras-related protein Rab-5B-like [KO:K07888]
114569879  rab5c; ras-related protein Rab-5C [KO:K07889]
114547890  ras-related protein Rab-5C-like [KO:K07889]
114554377  mon1a; vacuolar fusion protein MON1 homolog A [KO:K20195]
114554521  vacuolar fusion protein MON1 homolog B-like [KO:K20195]
114548052  ccz1; vacuolar fusion protein CCZ1 homolog [KO:K27045]
114553569  ras-related protein rab7-like isoform X1 [KO:K07897]
114553832  ras-related protein rab7 [KO:K07897]
114554790  ras-related protein rab7-like [KO:K07897]
114560144  TBC1 domain family member 15-like [KO:K20168]
114570305  tbc1d17; TBC1 domain family member 17 [KO:K19945]
114545794  fis1; mitochondrial fission 1 protein [KO:K17969]
114546354  atg9a; autophagy-related protein 9A [KO:K17907]
114565123  autophagy-related protein 9A-like [KO:K17907]
114561415  opa1; dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
114570421  transitional endoplasmic reticulum ATPase-like isoform X1 [KO:K13525]
114555309  vcp; transitional endoplasmic reticulum ATPase [KO:K13525]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
pflv04140  Autophagy - animal
pflv04210  Apoptosis
KO pathway
ko04137   
LinkDB

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