KEGG   PATHWAY: ppug04150
Entry
ppug04150                   Pathway                                
Name
mTOR signaling pathway - Pungitius pungitius (ninespine stickleback)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ppug04150  mTOR signaling pathway
ppug04150

Organism
Pungitius pungitius (ninespine stickleback) [GN:ppug]
Gene
119196091  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
119223676  large neutral amino acids transporter small subunit 1-like isoform X1 [KO:K13780]
119227398  4F2 cell-surface antigen heavy chain-like [KO:K06519]
119215231  4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
119223183  slc3a2a; solute carrier family 3 member 2a [KO:K06519]
119226635  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
119198835  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
119215685  V-type proton ATPase catalytic subunit A-like isoform X1 [KO:K02145] [EC:7.1.2.2]
119214190  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
119219619  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
119227909  atp6v1c2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 1-B [KO:K02148]
119197410  V-type proton ATPase subunit C 1-A-like [KO:K02148]
119194779  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
119210390  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
119196419  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
119210300  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
119226819  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
119203782  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
119215665  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
119197653  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
119228032  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
119210400  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
119223321  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
119197739  flcn; folliculin isoform X1 [KO:K09594]
119215884  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
119215568  rraga; ras-related GTP-binding protein A [KO:K16185]
119219113  rragcb; ras-related GTP binding Cb [KO:K16186]
119228180  ras-related GTP-binding protein D-like [KO:K16186]
119197810  rragca; ras-related GTP binding Ca [KO:K16186]
119219149  sesn2; sestrin-2 [KO:K20394]
119225088  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
119215666  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
119196974  mios; GATOR complex protein MIOS [KO:K20407]
119197002  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
119213125  wdr24; GATOR complex protein WDR24 [KO:K20408]
119194066  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
119194225  sec13; protein SEC13 homolog [KO:K14004]
119209231  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
119194182  nprl2; GATOR complex protein NPRL2 [KO:K20405]
119220534  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
119226275  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
119199032  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
119217415  rptor; regulatory-associated protein of mTOR [KO:K07204]
119220047  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
119222180  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119229807  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
119197381  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
119213230  mlst8; target of rapamycin complex subunit lst8 isoform X1 [KO:K08266]
119212604  telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
119222350  tti1; LOW QUALITY PROTEIN: TELO2-interacting protein 1 homolog [KO:K20403]
119226369  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
119224790  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
119219466  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
119197528  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
119198787  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
119227982  lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
119195172  si:ch73-21k16.1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
119209898  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
119229434  zgc:123305 isoform X1 [KO:K15728] [EC:3.1.3.4]
119226588  ulk1b; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
119225472  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
119223264  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
119226320  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
119224965  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
119214456  eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259]
119227325  eif4eb; eukaryotic translation initiation factor 4eb isoform X1 [KO:K03259]
119209359  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
119210020  eukaryotic translation initiation factor 4E-1A-like isoform X1 [KO:K03259]
119223385  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
119230207  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
119215503  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119218185  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
119229589  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
119218493  rps6; 40S ribosomal protein S6 [KO:K02991]
119220720  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
119213696  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
119209121  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
119222826  cab39l; calcium-binding protein 39-like [KO:K08272]
119210802  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
119211201  cab39; calcium-binding protein 39 [KO:K08272]
119226447  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
119217013  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119226595  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
119217409  tsc2; tuberin isoform X1 [KO:K07207]
119216326  tbc1d7; TBC1 domain family member 7 [KO:K20396]
119209615  rheb; GTP-binding protein Rheb [KO:K07208]
119229450  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
119213332  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
119214213  DNA damage-inducible transcript 4 protein-like [KO:K08270]
119205307  wnt1; protein Wnt-1 [KO:K03209]
119206525  protein Wnt-1 [KO:K03209]
119194174  protein Wnt-2b-A-like [KO:K00182]
119223146  protein Wnt-2b-A [KO:K00182]
119196658  wnt2; protein Wnt-2 isoform X1 [KO:K00182]
119213387  wnt3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
119206860  wnt3a; protein Wnt-3a [KO:K00312]
119194202  wnt4; protein Wnt-4a [KO:K00408]
119197257  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
119210739  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
119223485  wnt5a; protein Wnt-5a [KO:K00444]
119229296  wnt6b; protein Wnt-6 [KO:K00445]
119222026  protein Wnt-7a [KO:K00572]
119229729  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
119196467  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
119211216  protein Wnt-7b-like isoform X1 [KO:K00572]
119213735  wnt8b; protein Wnt-8b [KO:K00714]
119211003  protein Wnt-8a-like [KO:K00714]
119211049  protein Wnt-8a-like [KO:K00714]
119206790  wnt9a; protein Wnt-9a [KO:K01064]
119220495  wnt9b; protein Wnt-9b [KO:K01064]
119206524  protein Wnt-10b-like [KO:K01357]
119199284  LOW QUALITY PROTEIN: protein Wnt-10b-like [KO:K01357]
119229295  wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
119215921  wnt11; protein Wnt-11 [KO:K01384]
119211584  wnt16; protein Wnt-16 [KO:K01558]
119229039  frizzled-7-like [KO:K02432]
119197065  fzd1; frizzled-1 [KO:K02432]
119212661  frizzled-1-like [KO:K02432]
119219823  fzd2; frizzled-2 [KO:K02235]
119228540  frizzled-3-like [KO:K02329]
119195425  fzd3a; frizzled-3a [KO:K02329]
119217611  fzd4; frizzled-4 [KO:K02354]
119198611  fzd8a; frizzled-8a [KO:K02375]
119209476  frizzled-8-like [KO:K02375]
119228706  fzd5; frizzled-5 [KO:K02375]
119197920  fzd6; frizzled-6 [KO:K02376]
119211796  fzd9b; frizzled-9b [KO:K02842]
119225533  fzd10; frizzled-10 [KO:K02842]
119210756  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
119196636  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
119219138  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
119209814  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
119222589  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
119223279  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
119228572  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119218814  tumor necrosis factor-like isoform X1 [KO:K03156]
119223680  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
119197254  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
119224939  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119215349  ins; insulin [KO:K04526]
119207003  insulin-like growth factor I [KO:K05459]
119210507  igf1; insulin-like growth factor I [KO:K05459]
119209490  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
119217181  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
119198402  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
119195567  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
119219897  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
119228081  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119217531  son of sevenless homolog 1-like [KO:K03099]
119196409  GTPase HRas [KO:K02833]
119220140  zgc:55558 [KO:K07827]
119195920  kras; GTPase KRas isoform X1 [KO:K07827]
119210797  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
119221983  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
119195764  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119209642  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
119216703  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
119219913  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119224898  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119198509  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
119227250  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
119228203  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
119210968  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
119215070  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
119222532  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
119226302  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119209332  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119209420  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
119216917  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
119216976  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
119224672  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
119213100  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
119209321  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119222704  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119217096  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
119223188  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
119214113  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119212840  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119213165  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119213889  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119227745  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119211112  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119217961  akt3b; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119213096  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
119214000  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
119226859  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
119224655  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
119210515  proline-rich protein 5-like isoform X1 [KO:K20411]
119196479  prr5a; proline-rich protein 5a [KO:K20411]
119195705  proline-rich protein 5-like [KO:K20411]
119199437  rho-related GTP-binding protein RhoA-C [KO:K04513]
119199508  rho-related GTP-binding protein RhoA-C [KO:K04513]
119199518  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
119222158  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
119223161  rho-related GTP-binding protein RhoA-D [KO:K04513]
119223162  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
119229793  rhoca; ras homolog family member Ca isoform X1 [KO:K04513]
119229899  rho-related GTP-binding protein RhoA-B [KO:K04513]
119220222  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
119218609  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
119220027  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119217370  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
119198242  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119219595  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
119195264  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ppug00561  Glycerolipid metabolism
ppug04010  MAPK signaling pathway
ppug04140  Autophagy - animal
ppug04810  Regulation of actin cytoskeleton
ppug04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

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