KEGG   PATHWAY: pss04540
Entry
pss04540                    Pathway                                
Name
Gap junction - Pelodiscus sinensis (Chinese soft-shelled turtle)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pss04540  Gap junction
pss04540

Other DBs
GO: 0005921
Organism
Pelodiscus sinensis (Chinese soft-shelled turtle) [GN:pss]
Gene
102461824  GJA1; gap junction alpha-1 protein [KO:K07372]
102455876  GJD2; gap junction delta-2 protein [KO:K07373]
102444743  LOW QUALITY PROTEIN: gap junction delta-2 protein-like [KO:K07373]
102445645  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102453320  lysophosphatidic acid receptor 1-B-like [KO:K04289]
102452618  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
102453613  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
102453111  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102451145  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102452310  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102445898  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102453328  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
102443708  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102460895  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102443405  EGFR; epidermal growth factor receptor isoform X3 [KO:K04361] [EC:2.7.10.1]
102463609  GRB2; growth factor receptor-bound protein 2 isoform X2 [KO:K04364]
102453319  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102458741  SOS2; son of sevenless homolog 2 [KO:K03099]
102457627  HRAS; GTPase HRas isoform X2 [KO:K02833]
102447251  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
102450646  KRAS; GTPase KRas isoform X1 [KO:K07827]
102447991  NRAS; GTPase NRas [KO:K07828]
102458748  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102443595  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102457075  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102453948  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102462669  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102448094  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102451373  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X4 [KO:K04463] [EC:2.7.12.2]
102463278  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102457342  tubulin alpha-3 chain isoform X1 [KO:K07374]
102445223  tubulin alpha-3 chain-like [KO:K07374]
102446337  tubulin alpha-3 chain [KO:K07374]
102446572  tubulin alpha-3 chain-like isoform X3 [KO:K07374]
102445276  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
102456974  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102457222  tubulin alpha-1B chain [KO:K07374]
102457470  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102450295  tubulin alpha-8 chain [KO:K07374]
102444792  tubulin alpha-4 chain [KO:K07374]
102455221  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
102456719  tubulin beta chain [KO:K07375]
102459913  TUBB3; LOW QUALITY PROTEIN: tubulin beta-3 chain [KO:K07375]
102451904  TUBB4A; tubulin beta-4A chain [KO:K07375]
102447709  TUBB1; tubulin beta-1 chain [KO:K07375]
102454956  tubulin beta-2 chain [KO:K07375]
102455457  tubulin beta-1 chain [KO:K07375]
102456849  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
102448219  CDK1; cyclin-dependent kinase 1 isoform X2 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102444512  TJP1; tight junction protein ZO-1 isoform X5 [KO:K05701]
102447221  ADRB1; beta-1 adrenergic receptor [KO:K04141]
102457277  DRD1; D(1A) dopamine receptor [KO:K04144]
102447036  guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
102446398  DRD2; D(2) dopamine receptor isoform X3 [KO:K04145]
102445759  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102444057  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102463305  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102451515  adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102461993  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102448834  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102449192  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102448969  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102448197  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102454969  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102458631  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102462551  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
102462937  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
102444453  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
102460135  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
102454127  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
102455465  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102454459  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102455767  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102460883  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102449462  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102461092  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102462538  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
102453428  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102449833  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102459336  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102449325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102459783  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102444454  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
102446826  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
102447071  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X2 [KO:K12319] [EC:4.6.1.2]
102452749  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
102451605  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
pss04010  MAPK signaling pathway
pss04020  Calcium signaling pathway
pss04060  Cytokine-cytokine receptor interaction
pss04070  Phosphatidylinositol signaling system
pss04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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