KEGG   PATHWAY: pss04010
Entry
pss04010                    Pathway                                
Name
MAPK signaling pathway - Pelodiscus sinensis (Chinese soft-shelled turtle)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pss04010  MAPK signaling pathway
pss04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Pelodiscus sinensis (Chinese soft-shelled turtle) [GN:pss]
Gene
102443378  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102443405  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
102443595  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102443661  FGF23; fibroblast growth factor 23 [KO:K22428]
102443708  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102443772  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102443920  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
102443925  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
102444010  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
102444025  KITLG; kit ligand isoform X1 [KO:K05461]
102444055  RAP1B; ras-related protein Rap-1b [KO:K07836]
102444162  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
102444169  [KO:K16342] [EC:3.1.1.4]
102444275  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102444358  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
102444390  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102444430  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102444710  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102444715  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102444760  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102445093  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102445100  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102445198  INS; insulin [KO:K04526]
102445212  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
102445228  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102445240  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102445357  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102445433  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102445459  IGF2; insulin-like growth factor 2 [KO:K13769]
102445524  BDNF; neurotrophic factor BDNF precursor form isoform X1 [KO:K04355]
102445541  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102445585  TGFA; protransforming growth factor alpha [KO:K08774]
102445616  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102445709  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102445744  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
102445775  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
102445882  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
102445892  CRKL; crk-like protein [KO:K04438]
102446411  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102446638  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
102446651  [KO:K05096] [EC:2.7.10.1]
102446659  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
102446945  [KO:K16342] [EC:3.1.1.4]
102446950  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X4 [KO:K04414] [EC:2.7.11.1]
102446951  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
102447079  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102447163  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102447181  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102447187  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102447240  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
102447251  [KO:K07827]
102447276  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102447391  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102447859  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102447884  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
102447983  NF1; neurofibromin isoform X1 [KO:K08052]
102447991  NRAS; GTPase NRas [KO:K07828]
102448013  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102448094  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102448135  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
102448244  IL-1beta; interleukin-1 beta [KO:K04519]
102448363  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102448379  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102448586  [KO:K16342] [EC:3.1.1.4]
102448752  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
102448775  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102448785  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102448788  RASGRP4; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 4 [KO:K04350]
102448824  FGF20; fibroblast growth factor 20 [KO:K04358]
102448827  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K05448]
102448831  [KO:K16342] [EC:3.1.1.4]
102448983  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
102448997  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
102449068  [KO:K16342] [EC:3.1.1.4]
102449249  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102449310  [KO:K16342] [EC:3.1.1.4]
102449325  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102449403  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102449445  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
102449532  [KO:K03156]
102449551  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102449623  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
102449635  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102449741  MRAS; ras-related protein M-Ras [KO:K07831]
102449936  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102449938  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102449993  ARRB2; beta-arrestin-2 isoform X2 [KO:K04439]
102450041  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102450053  [KO:K16342] [EC:3.1.1.4]
102450076  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
102450143  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
102450169  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
102450298  PSPN; persephin [KO:K25416]
102450646  KRAS; GTPase KRas isoform X4 [KO:K07827]
102450997  FGF16; fibroblast growth factor 16 isoform X2 [KO:K04358]
102451068  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
102451087  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102451114  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
102451139  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102451145  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102451205  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
102451227  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102451252  NGF; beta-nerve growth factor [KO:K02582]
102451307  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102451309  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
102451373  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102451409  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102451433  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
102451479  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102451529  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
102451554  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X16 [KO:K04850]
102451603  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
102451624  [KO:K16342] [EC:3.1.1.4]
102451693  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102451801  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102451869  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102451883  PGF; placenta growth factor isoform X1 [KO:K16859]
102452242  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102452248  [KO:K16342] [EC:3.1.1.4]
102452310  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102452356  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102452394  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102452427  MAX; protein max isoform X1 [KO:K04453]
102452480  VEGFD; vascular endothelial growth factor D [KO:K05449]
102452501  [KO:K16342] [EC:3.1.1.4]
102452619  HSPB1; heat shock protein beta-1 [KO:K04455]
102452666  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102452758  FGF1; fibroblast growth factor 1 [KO:K18496]
102452763  [KO:K16342] [EC:3.1.1.4]
102452855  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
102452874  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
102452927  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102453073  STMN1; stathmin [KO:K04381]
102453103  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
102453111  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102453141  [KO:K03283]
102453224  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102453260  EREG; proepiregulin [KO:K09784]
102453283  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
102453289  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102453319  SOS1; son of sevenless homolog 1 [KO:K03099]
102453328  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102453442  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102453558  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102453695  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
102453748  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102453850  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102453880  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
102453948  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102454019  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
102454064  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102454085  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102454088  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
102454096  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102454148  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102454421  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102454484  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 [KO:K04465]
102454531  FOS; protein c-Fos [KO:K04379]
102454556  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
102454616  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102454634  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102454656  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
102454676  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102454869  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102454880  [KO:K04421] [EC:2.7.11.25]
102454948  IGF1; insulin-like growth factor 1 precursor [KO:K05459]
102454969  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102455008  JUN; transcription factor Jun [KO:K04448]
102455075  [KO:K04439]
102455188  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102455375  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
102455379  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
102455384  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
102455473  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
102455576  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102455784  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102455840  [KO:K03283]
102455939  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102456006  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
102456174  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102456320  [KO:K04438]
102456369  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102456411  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
102456729  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102456773  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102456796  RELB; transcription factor RelB isoform X1 [KO:K09253]
102456802  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
102456820  FGF3; fibroblast growth factor 3 [KO:K04358]
102457025  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102457075  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102457099  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102457114  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102457123  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102457132  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
102457133  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102457223  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102457231  FGF4; fibroblast growth factor 4 [KO:K04358]
102457251  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102457483  FGF19; fibroblast growth factor 19 [KO:K22603]
102457520  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102457523  RASA2; ras GTPase-activating protein 2 [KO:K08053]
102457599  [KO:K04388] [EC:2.7.11.30]
102457627  HRAS; GTPase HRas isoform X1 [KO:K02833]
102457798  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
102457804  RELA; transcription factor p65 isoform X1 [KO:K04735]
102457830  CRK; adapter molecule crk isoform X1 [KO:K04438]
102457900  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102458196  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102458365  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102458559  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102458631  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
102458741  SOS2; son of sevenless homolog 2 [KO:K03099]
102458748  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102458999  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102459083  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102459127  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
102459207  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102459229  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102459239  AREG; amphiregulin [KO:K09782]
102459336  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102459372  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102459702  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102459783  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102459971  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102460132  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
102460331  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102460370  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102460494  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102460565  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102460734  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102460770  MEF2C; myocyte-specific enhancer factor 2C isoform X7 [KO:K04454]
102460773  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102460867  [KO:K05466]
102460895  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
102461243  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
102461251  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
102461506  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102461533  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102461781  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102461994  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
102462016  FGF6; fibroblast growth factor 6 [KO:K04358]
102462221  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102462429  [KO:K04441] [EC:2.7.11.24]
102462557  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102462672  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102462684  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102462875  [KO:K16342] [EC:3.1.1.4]
102463316  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102463390  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102463398  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102463404  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
102463448  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102463483  EFNA2; ephrin-A2 [KO:K05462]
102463609  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102463619  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
102463813  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
102463908  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
102463924  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102463929  [KO:K04386]
102463962  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
102464024  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
102464040  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
106731841  RRAS; ras-related protein R-Ras isoform X1 [KO:K07830]
106732344  SRF; serum response factor isoform X1 [KO:K04378]
106732453  [KO:K16342] [EC:3.1.1.4]
106732455  [KO:K16342] [EC:3.1.1.4]
106732780  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112544112  [KO:K03283]
112547289  [KO:K16342] [EC:3.1.1.4]
112547387  [KO:K16342] [EC:3.1.1.4]
142818158  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
142818178  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
142818897  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
142819020  JUND; transcription factor JunD [KO:K04449]
142819509  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
142823842  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
142824493  [KO:K03283]
142825561  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
142829233  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
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Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pss04070  Phosphatidylinositol signaling system
pss04110  Cell cycle
pss04115  p53 signaling pathway
pss04210  Apoptosis
pss04310  Wnt signaling pathway
KO pathway
ko04010   

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