KEGG   PATHWAY: ptao04144
Entry
ptao04144                   Pathway                                
Name
Endocytosis - Phyllopteryx taeniolatus (common seadragon)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
ptao04144  Endocytosis
ptao04144

Other DBs
GO: 0006897
Organism
Phyllopteryx taeniolatus (common seadragon) [GN:ptao]
Gene
133467983  arf6a; ADP-ribosylation factor 6a [KO:K07941]
133487395  ADP-ribosylation factor 6-like [KO:K07941]
133489275  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
133465313  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
133471262  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
133479402  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
133480982  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
133475343  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
133490378  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
133470472  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
133467443  pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
133487840  pld1a; phospholipase D1a isoform X1 [KO:K01115] [EC:3.1.4.4]
133489403  dynamin-3-like isoform X1 [KO:K01528] [EC:3.6.5.5]
133490177  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
133475717  dynamin-1-like isoform X1 [KO:K01528] [EC:3.6.5.5]
133466522  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
133476303  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
133476243  clta; clathrin light chain A isoform X1 [KO:K04644]
133484509  cltb; clathrin light chain B isoform X1 [KO:K04645]
133466748  cltca; clathrin, heavy chain a (Hc) [KO:K04646]
133475132  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
133481797  clathrin heavy chain 1-like isoform X1 [KO:K04646]
133465536  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
133473332  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
133467116  ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
133488548  AP-2 complex subunit mu-A-like [KO:K11826]
133481986  ap2s1; AP-2 complex subunit sigma [KO:K11827]
133481769  ehd2b; EH domain-containing protein 2b [KO:K12469]
133482085  EH domain-containing protein 2-like [KO:K12469]
133470130  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
133470860  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
133486353  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
133488724  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
133464954  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
133480799  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
133474713  mothers against decapentaplegic homolog 2 [KO:K04500]
133470963  mothers against decapentaplegic homolog 3 [KO:K23605]
133478470  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
133470115  tfr1b; transferrin receptor 1b [KO:K06503]
133489535  tfr1a; transferrin receptor 1a isoform X1 [KO:K06503]
133488957  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
133470267  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
133480405  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
133485443  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
133488274  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
133466939  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
133478285  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
133474106  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
133467753  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
133481864  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
133479118  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
133470063  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
133476873  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 isoform X1 [KO:K11247]
133488943  endophilin-A2-like isoform X1 [KO:K11247]
133472735  endophilin-A1-like isoform X1 [KO:K11247]
133480499  sh3gl1b; SH3-domain GRB2-like 1b [KO:K11247]
133470023  sh3glb1a; endophilin-B1a [KO:K11248]
133488043  endophilin-B1-like isoform X1 [KO:K11248]
133490379  sh3glb2b; endophilin-B2b isoform X1 [KO:K21269]
133475453  endophilin-B2-like [KO:K21269]
133488814  amph; amphiphysin isoform X1 [KO:K12562]
133486421  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
133480793  bin1b; myc box-dependent-interacting protein 1b isoform X1 [KO:K12562]
133470670  epsin-1-like [KO:K12471]
133465496  epn2; epsin-2 isoform X1 [KO:K12471]
133466133  epn3a; epsin-3 isoform X1 [KO:K12471]
133479229  epn1a; epsin-1 isoform X1 [KO:K12471]
133476322  epn3b; epsin-3 isoform X1 [KO:K12471]
133488675  epidermal growth factor receptor substrate 15-like isoform X1 [KO:K12472]
133488873  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
133480606  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
133480998  eps15l1a; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
133467008  sparta; spartin a isoform X1 [KO:K19366]
133482552  spartb; spartin b isoform X1 [KO:K19366]
133469461  nedd4a; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
133465259  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
133471632  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
133471939  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
133485858  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
133484212  itcha; itchy E3 ubiquitin protein ligase a isoform X1 [KO:K05632] [EC:2.3.2.26]
133475366  itchb; itchy E3 ubiquitin protein ligase b [KO:K05632] [EC:2.3.2.26]
133477524  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
133465777  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
133465816  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
133470565  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
133477114  ldlrb; low-density lipoprotein receptor isoform X1 [KO:K12473]
133465659  ldlra; low density lipoprotein receptor a [KO:K12473]
133470909  ldlrap1a; low density lipoprotein receptor adapter protein 1a [KO:K12474]
133472366  si:dkey-19b23.8; uncharacterized protein si:dkey-19b23.8 [KO:K12474]
133487682  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
133490223  dab2; disabled homolog 2 isoform X1 [KO:K12475]
133479242  C-C chemokine receptor type 1 [KO:K04180]
133469731  C-X-C chemokine receptor type 2-like [KO:K05050]
133486943  C-X-C chemokine receptor type 2-like [KO:K05050]
133489284  C-X-C chemokine receptor type 4-like isoform X1 [KO:K04189]
133487079  C-X-C chemokine receptor type 4-like [KO:K04189]
133488644  grk7a; rhodopsin kinase grk7a isoform X1 [KO:K00909] [EC:2.7.11.14]
133466888  grk1b; LOW QUALITY PROTEIN: rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
133486723  rhodopsin kinase GRK1-like [KO:K00909] [EC:2.7.11.14]
133474504  grk1a; LOW QUALITY PROTEIN: rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
133482429  grk7b; rhodopsin kinase grk7-b [KO:K00909] [EC:2.7.11.14]
133490320  grk3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
133465201  grk5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
133467725  grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
133475580  grk5l; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
133476362  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
133467093  arrestin red cell [KO:K04439]
133482157  beta-arrestin-1-like [KO:K04439]
133477689  LOW QUALITY PROTEIN: actin nucleation-promoting factor WASL-like [KO:K23612]
133472253  actin nucleation-promoting factor WASL-like isoform X1 [KO:K23612]
133472256  actin nucleation-promoting factor WASL-like isoform X1 [KO:K23612]
133472579  zgc:101810; actin-related protein 2 isoform X1 [KO:K17260]
133486256  actin-related protein 2-A [KO:K17260]
133479725  actin-related protein 3-like [KO:K18584]
133487209  actin-related protein 3 [KO:K18584]
133476671  actin-related protein 2/3 complex subunit 1B-B-like [KO:K05757]
133476672  actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
133465405  zgc:86896; actin-related protein 2/3 complex subunit 1A-A isoform X1 [KO:K05757]
133478696  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
133465229  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
133483256  arpc4l; actin related protein 2/3 complex, subunit 4, like [KO:K05755]
133484021  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
133481046  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
133476624  wipf2a; WAS/WASL-interacting protein family member 2 [KO:K19475]
133470869  wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
133485827  WAS/WASL-interacting protein family member 1-like [KO:K19475]
133484862  heat shock 70 kDa protein 1-like [KO:K03283]
133479267  hsc70; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
133466732  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
133481947  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
133468728  heat shock 70 kDa protein 1 [KO:K03283]
133481412  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
133477580  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
133479675  washc5; WASH complex subunit 5 isoform X1 [KO:K18464]
133485869  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
133478310  wash1; WASH complex subunit 1 [KO:K18461]
133471770  washc3; WASH complex subunit 3 isoform X1 [KO:K18463]
133489905  capza1b; F-actin-capping protein subunit alpha-1b isoform X1 [KO:K10364]
133478153  F-actin-capping protein subunit alpha-2 [KO:K10364]
133483382  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
133487564  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
133466989  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
133474331  vps26a; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
133481891  vacuolar protein sorting-associated protein 26B-like isoform X1 [KO:K18466]
133468744  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
133467110  snx12; sorting nexin-12 [KO:K17918]
133468182  snx3; sorting nexin-3 isoform X1 [KO:K17918]
133467292  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
133474854  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
133483434  rab7a; ras-related protein Rab-7a [KO:K07897]
133483854  ras-related protein rab7-like [KO:K07897]
133466131  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
133486852  stam2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
133477788  tsg101a; tumor susceptibility 101a [KO:K12183]
133465094  mvb12ba; multivesicular body subunit 12Ba isoform X1 [KO:K12186]
133475618  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
133476293  mvb12a; multivesicular body subunit 12A [KO:K12186]
133471150  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
133477296  vps37c; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
133466999  vps37d; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
133474745  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
133476251  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
133469552  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
133467492  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
133469033  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
133466627  charged multivesicular body protein 6-like [KO:K12195]
133468954  chmp6b; charged multivesicular body protein 6 isoform X1 [KO:K12195]
133483935  charged multivesicular body protein 4b-like isoform X1 [KO:K12194]
133474621  charged multivesicular body protein 4b-like isoform X1 [KO:K12194]
133470153  chmp4c; charged multivesicular body protein 4c [KO:K24782]
133487534  chmp3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
133469553  chmp2a; charged multivesicular body protein 2a [KO:K12191]
133486764  chmp2ba; charged multivesicular body protein 2Ba isoform X1 [KO:K12192]
133475674  chmp7; charged multivesicular body protein 7 [KO:K15053]
133477810  vps4a; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
133480923  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
133488466  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
133468714  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
133478041  chmp1a; charged multivesicular body protein 1a [KO:K12197]
133467668  chmp1b; charged multivesicular body protein 1b [KO:K12197]
133488797  chmp5a; charged multivesicular body protein 5 [KO:K12198]
133470004  chmp5b; charged multivesicular body protein 5 [KO:K12198]
133470377  ist1; IST1 homolog isoform X1 [KO:K19476]
133471104  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
133470027  spg21; maspardin isoform X1 [KO:K19367]
133468199  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
133477965  snx1a; sorting nexin-1a [KO:K17917]
133471581  sorting nexin-1-like isoform X1 [KO:K17917]
133475762  snx2; sorting nexin-2 [KO:K17917]
133483609  si:dkey-28n18.9; sorting nexin-6 [KO:K17920]
133485846  snx5; sorting nexin-5 [KO:K17920]
133488313  snx6; sorting nexin-6 isoform X1 [KO:K17920]
133483627  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
133485868  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
133477792  GTPase HRas [KO:K02833]
133476680  uncharacterized protein LOC133476680 isoform X1 [KO:K05069]
133466366  il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
133467109  LOW QUALITY PROTEIN: cytokine receptor common subunit gamma-like [KO:K05070]
133483373  rho-related GTP-binding protein RhoA-B [KO:K04513]
133484190  rho-related GTP-binding protein RhoA-D [KO:K04513]
133486779  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
133481178  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
133470706  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133470775  major histocompatibility complex class I-related gene protein-like [KO:K06751]
133470777  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133470781  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133470924  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
133470925  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
133470967  major histocompatibility complex class I-related gene protein-like [KO:K06751]
133470982  uncharacterized protein LOC133470982 [KO:K06751]
133471079  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133471272  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133471280  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133471481  major histocompatibility complex class I-related gene protein-like [KO:K06751]
133471498  H-2 class I histocompatibility antigen, D-D alpha chain-like isoform X1 [KO:K06751]
133471500  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
133471501  H-2 class I histocompatibility antigen, K-Q alpha chain-like isoform X1 [KO:K06751]
133471502  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133471503  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
133471504  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133471505  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133471507  major histocompatibility complex class I-related gene protein-like [KO:K06751]
133471508  major histocompatibility complex class I-related gene protein-like [KO:K06751]
133473269  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
133473505  major histocompatibility complex class I-related gene protein-like [KO:K06751]
133473752  major histocompatibility complex class I-related gene protein-like [KO:K06751]
133473933  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
133466376  rtbdn; retbindin [KO:K13649]
133482581  folr; folate receptor [KO:K13649]
133478155  cav1; caveolin-1 [KO:K06278]
133483921  cav4a; caveolin-2 [KO:K12958]
133478156  cav2; caveolin-2 [KO:K12958]
133483942  cav3; caveolin-3 [KO:K12959]
133468399  ehd3; EH domain-containing protein 3 [KO:K12476]
133478988  ehd4; EH domain-containing protein 4 [KO:K12477]
133477703  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
133471060  ras-related protein Rab-5C-like isoform X1 [KO:K07887]
133479251  ras-related protein Rab-5A [KO:K07887]
133486978  rab5b; ras-related protein Rab-5B [KO:K07888]
133469458  ras-related protein Rab-5C-like [KO:K07889]
133465545  rab5c; ras-related protein Rab-5C isoform X1 [KO:K07889]
133467287  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
133476381  rabenosyn-5 isoform X1 [KO:K12481]
133474326  rab4a; ras-related protein Rab-4A [KO:K07879]
133484538  rufy1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
133474342  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
133484954  ehd1a; EH domain-containing protein 1a [KO:K12483]
133471100  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
133486929  snx4; sorting nexin-4 [KO:K17919]
133484225  rab22a; ras-related protein Rab-22A isoform X1 [KO:K07891]
133488460  rab31; ras-related protein Rab-31 [KO:K07891]
133468730  rab10; ras-related protein Rab-10 [KO:K07903]
133488650  ras-related protein Rab-8A-like [KO:K07901]
133480438  ras-related protein Rab-8A [KO:K07901]
133466401  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
133474741  rab35b; ras-related protein Rab-35b isoform X1 [KO:K07876]
133479000  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
133474473  rab11a; ras-related protein Rab-11A [KO:K07904]
133488895  ras-related protein Rab-11B [KO:K07905]
133480581  ras-related protein Rab-11B-like isoform X1 [KO:K07905]
133480582  ras-related protein Rab-11B-like isoform X1 [KO:K07905]
133485097  rab11fip5b; uncharacterized protein rab11fip5b isoform X1 [KO:K12484]
133485763  rab11 family-interacting protein 2 isoform X1 [KO:K12484]
133487327  rab11fip5a; uncharacterized protein rab11fip5a isoform X1 [KO:K12484]
133475527  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
133476331  zfyve27; protrudin isoform X1 [KO:K19368]
133488866  kinesin-1 heavy chain isoform X1 [KO:K10396]
133470166  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
133483873  kif5ab; kinesin heavy chain [KO:K10396]
133474831  kif5aa; kinesin family member 5Aa isoform X1 [KO:K10396]
133477144  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
133465775  rab11fip4a; rab11 family-interacting protein 4A isoform X1 [KO:K12485]
133468868  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
133489491  partitioning defective 3 homolog isoform X1 [KO:K04237]
133470529  partitioning defective 3 homolog isoform X1 [KO:K04237]
133470872  pard6gb; par-6 family cell polarity regulator gamma b isoform X1 [KO:K06093]
133477866  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
133485459  pard6b; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
133486900  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
133483015  cell division control protein 42 homolog isoform X1 [KO:K04393]
133477984  cell division control protein 42 homolog isoform X1 [KO:K04393]
133471519  cell division control protein 42 homolog [KO:K04393]
133479196  cdc42l; cell division cycle 42, like [KO:K04393]
133476435  smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
133471273  smap2; stromal membrane-associated protein 2 [KO:K12486]
133485363  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
133481968  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
133490000  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
133475418  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
133470433  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
133483925  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
133487321  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
133468467  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
133488145  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X1 [KO:K12488]
133483459  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
133472773  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
133474171  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
133480386  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
133482278  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein isoform X1 [KO:K12489]
133482039  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K18439]
133467036  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18440]
133472895  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
133484557  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
133488560  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
133480985  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
133477147  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
133483624  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
133483340  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
133471754  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
133474461  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
133489771  PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
133484525  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
133485709  uncharacterized protein LOC133485709 isoform X1 [KO:K12494]
133469125  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
133476806  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
133478306  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
133472049  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
133479524  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
133487548  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
133476692  cytohesin-4-like isoform X1 [KO:K18441]
133466214  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
133466460  cytohesin-1 isoform X1 [KO:K18441]
133479822  cyth2; cytohesin-2 isoform X1 [KO:K18441]
133468899  cytohesin-3 isoform X1 [KO:K18441]
133469261  cytohesin-1-like isoform X1 [KO:K18441]
133469930  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
133485449  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
133486058  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
133469733  arf2b; ADP-ribosylation factor 2b [KO:K07937]
133483420  uncharacterized protein LOC133483420 isoform X1 [KO:K07937]
133489121  ADP-ribosylation factor 1-like [KO:K07937]
133483820  ADP-ribosylation factor 3 [KO:K07938]
133478385  arf3a; ADP-ribosylation factor 3a [KO:K07938]
133477839  ADP-ribosylation factor 4-like [KO:K07939]
133472201  ADP-ribosylation factor 4 isoform X1 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
ptao04060  Cytokine-cytokine receptor interaction
ptao04070  Phosphatidylinositol signaling system
ptao04130  SNARE interactions in vesicular transport
ptao04142  Lysosome
ptao04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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