KEGG   PATHWAY: sanh04150
Entry
sanh04150                   Pathway                                
Name
mTOR signaling pathway - Sinocyclocheilus anshuiensis
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
sanh04150  mTOR signaling pathway
sanh04150

Organism
Sinocyclocheilus anshuiensis [GN:sanh]
Gene
107654150  large neutral amino acids transporter small subunit 1-like [KO:K13780]
107701543  large neutral amino acids transporter small subunit 1-like [KO:K13780]
107669341  4F2 cell-surface antigen heavy chain-like [KO:K06519]
107700018  4F2 cell-surface antigen heavy chain-like [KO:K06519]
107702063  LOW QUALITY PROTEIN: 4F2 cell-surface antigen heavy chain-like [KO:K06519]
107683549  4F2 cell-surface antigen heavy chain-like [KO:K06519]
107683574  4F2 cell-surface antigen heavy chain-like [KO:K06519]
107670042  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
107665474  sodium-coupled neutral amino acid transporter 9 [KO:K14995]
107701669  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
107687683  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
107672757  V-type proton ATPase catalytic subunit A-like isoform X1 [KO:K02145] [EC:7.1.2.2]
107654231  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
107687718  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
107663287  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
107671090  V-type proton ATPase subunit B, brain isoform [KO:K02147]
107678016  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
107702090  V-type proton ATPase subunit C 1-B-like isoform X1 [KO:K02148]
107687954  V-type proton ATPase subunit C 1-A-like [KO:K02148]
107677660  V-type proton ATPase subunit C 1-A-like [KO:K02148]
107687850  V-type proton ATPase subunit C 1-A-like [KO:K02148]
107653836  V-type proton ATPase subunit C 1-B [KO:K02148]
107659089  V-type proton ATPase subunit C 1-A [KO:K02148]
107704057  V-type proton ATPase subunit D [KO:K02149]
107669460  V-type proton ATPase subunit D-like [KO:K02149]
107701013  V-type proton ATPase subunit E 1-like [KO:K02150]
107686663  V-type proton ATPase subunit E 1-like [KO:K02150]
107656431  V-type proton ATPase subunit E 1-like [KO:K02150]
107658907  V-type proton ATPase subunit E 1-like [KO:K02150]
107699062  V-type proton ATPase subunit F [KO:K02151]
107694161  V-type proton ATPase subunit F [KO:K02151]
107691729  V-type proton ATPase subunit G 1-like [KO:K02152]
107663786  V-type proton ATPase subunit G 1-like [KO:K02152]
107664082  V-type proton ATPase subunit H isoform X1 [KO:K02144]
107686042  V-type proton ATPase subunit H isoform X1 [KO:K02144]
107670063  ragulator complex protein LAMTOR1-like [KO:K20397]
107669907  ragulator complex protein LAMTOR1-like [KO:K20397]
107669909  ragulator complex protein LAMTOR1-like [KO:K20397]
107688283  ragulator complex protein LAMTOR2-like [KO:K20398]
107671438  ragulator complex protein LAMTOR2 isoform X1 [KO:K20398]
107667072  ragulator complex protein LAMTOR3 [KO:K04370]
107666558  ragulator complex protein LAMTOR3 [KO:K04370]
107699063  ragulator complex protein LAMTOR4-like [KO:K20399]
107694163  ragulator complex protein LAMTOR4 [KO:K20399]
107678981  ragulator complex protein LAMTOR5-like [KO:K16344]
107668015  ragulator complex protein LAMTOR5-like [KO:K16344]
107673020  folliculin-like isoform X1 [KO:K09594]
107692552  folliculin-like isoform X1 [KO:K09594]
107692965  folliculin-interacting protein 1-like isoform X1 [KO:K20400]
107661769  folliculin-interacting protein 1-like [KO:K20400]
107702372  folliculin-interacting protein 2-like [KO:K20401]
107656063  folliculin-interacting protein 2-like [KO:K20401]
107674885  ras-related GTP-binding protein A-like [KO:K16185]
107688597  ras-related GTP-binding protein A [KO:K16185]
107704952  ras-related GTP-binding protein C [KO:K16186]
107700741  ras-related GTP-binding protein C-like [KO:K16186]
107680791  ras-related GTP-binding protein D-like [KO:K16186]
107681629  ras-related GTP-binding protein C-like [KO:K16186]
107693082  ras-related GTP-binding protein D-like [KO:K16186]
107669953  ras-related GTP-binding protein C-like [KO:K16186]
107696562  sestrin-2-like isoform X1 [KO:K20394]
107697045  sestrin-2-like [KO:K20394]
107704487  LOW QUALITY PROTEIN: GATS-like protein 3 [KO:K23080]
107685562  GATS-like protein 2 [KO:K23081]
107681899  GATS-like protein 2 [KO:K23081]
107671474  WD repeat-containing protein mio [KO:K20407]
107688218  LOW QUALITY PROTEIN: WD repeat-containing protein mio-like [KO:K20407]
107686948  nucleoporin seh1-like [KO:K14299]
107668717  nucleoporin seh1 isoform X1 [KO:K14299]
107666589  nucleoporin seh1-like [KO:K14299]
107667227  WD repeat-containing protein 24 [KO:K20408]
107677125  WD repeat-containing protein 24-like [KO:K20408]
107662905  WD repeat-containing protein 59-like [KO:K20409]
107686576  WD repeat-containing protein 59-like isoform X1 [KO:K20409]
107691189  protein SEC13 homolog [KO:K14004]
107657312  protein SEC13 homolog [KO:K14004]
107686465  DEP domain-containing protein 5-like isoform X1 [KO:K20404]
107687976  DEP domain-containing protein 5-like isoform X1 [KO:K20404]
107654265  nprl2; nitrogen permease regulator 2-like protein isoform X1 [KO:K20405]
107672508  nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
107670498  nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
107703541  S-phase kinase-associated protein 2-like isoform X1 [KO:K03875]
107681151  S-phase kinase-associated protein 2-like isoform X1 [KO:K03875]
107679332  E3 ubiquitin-protein ligase rnf152-like [KO:K15705] [EC:2.3.2.27]
107674343  E3 ubiquitin-protein ligase rnf152-like [KO:K15705] [EC:2.3.2.27]
107669526  regulatory-associated protein of mTOR-like [KO:K07204]
107701211  rptor; regulatory-associated protein of mTOR [KO:K07204]
107680841  proline-rich AKT1 substrate 1-like [KO:K16184]
107687628  uncharacterized protein LOC107687628 [KO:K16184]
107687131  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
107679101  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
107673035  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
107655034  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
107685573  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
107699873  target of rapamycin complex subunit lst8 [KO:K08266]
107669207  target of rapamycin complex subunit lst8-like [KO:K08266]
107677315  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
107694415  TELO2-interacting protein 1 homolog [KO:K20403]
107694419  TELO2-interacting protein 1 homolog [KO:K20403]
107656170  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
107704176  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
107698542  clip1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
107702939  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
107657570  growth factor receptor-bound protein 10-like [KO:K20064]
107704094  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
107656633  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
107684229  growth factor receptor-bound protein 10-like [KO:K20064]
107667783  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
107664080  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
107674073  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
107690826  phosphatidate phosphatase LPIN3-like [KO:K15728] [EC:3.1.3.4]
107697727  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
107666669  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
107685350  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
107686047  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
107692289  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
107659619  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
107661377  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
107684495  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
107657566  serine/threonine-protein kinase ULK2-like isoform X1 [KO:K08269] [EC:2.7.11.1]
107662799  serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
107703566  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
107662096  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-1B-like [KO:K03259]
107702907  eukaryotic translation initiation factor 4E-1B-like [KO:K03259]
107690176  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
107679374  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
107680975  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
107696296  eukaryotic translation initiation factor 4E-1A [KO:K03259]
107678496  eukaryotic translation initiation factor 4E-like [KO:K03259]
107660478  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
107692895  eukaryotic translation initiation factor 4E type 2-like isoform X1 [KO:K03259]
107699259  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107701421  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107659922  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107693887  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107681397  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
107666323  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
107667299  eukaryotic translation initiation factor 4B-like [KO:K03258]
107673526  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
107676127  40S ribosomal protein S6-like [KO:K02991]
107692160  40S ribosomal protein S6 [KO:K02991]
107658471  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
107693497  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
107672654  STE20-related kinase adapter protein beta-like [KO:K17532]
107686750  STE20-related kinase adapter protein beta-like [KO:K17532]
107702084  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
107681921  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
107698862  calcium-binding protein 39 [KO:K08272]
107695174  calcium-binding protein 39-like [KO:K08272]
107692130  cab39l; LOW QUALITY PROTEIN: calcium-binding protein 39-like [KO:K08272]
107658085  calcium-binding protein 39-like [KO:K08272]
107661385  calcium-binding protein 39-like [KO:K08272]
107676861  calcium-binding protein 39-like [KO:K08272]
107691024  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
107697327  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
107687345  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
107693840  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
107690665  hamartin-like isoform X1 [KO:K07206]
107686900  hamartin-like [KO:K07206]
107679850  tsc1; hamartin isoform X1 [KO:K07206]
107681228  hamartin-like isoform X1 [KO:K07206]
107703706  tuberin-like [KO:K07207]
107700795  LOW QUALITY PROTEIN: tuberin-like [KO:K07207]
107672946  tbc1d7; TBC1 domain family member 7 isoform X1 [KO:K20396]
107694907  GTP-binding protein Rheb-like [KO:K07208]
107676829  GTP-binding protein Rheb [KO:K07208]
107653878  GTP-binding protein Rheb-like isoform X1 [KO:K07208]
107659673  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
107688058  DNA damage-inducible transcript 4 protein-like [KO:K08270]
107695811  protein Wnt-1 [KO:K03209]
107681946  protein Wnt-1-like [KO:K03209]
107660945  protein Wnt-2 [KO:K00182]
107669677  protein Wnt-2b-A-like [KO:K00182]
107679746  protein Wnt-2b-A [KO:K00182]
107666178  protein Wnt-2b-A-like [KO:K00182]
107655781  protein Wnt-2b-A-like [KO:K00182]
107661901  protein Wnt-3a-like [KO:K00312]
107657278  proto-oncogene Wnt-3 [KO:K00312]
107671672  protein Wnt-3a [KO:K00312]
107665892  proto-oncogene Wnt-3-like [KO:K00312]
107671942  protein Wnt-4-like [KO:K00408]
107704912  protein Wnt-4-like [KO:K00408]
107654388  protein Wnt-4a [KO:K00408]
107654407  protein Wnt-4a-like [KO:K00408]
107658849  protein Wnt-5b isoform X1 [KO:K00444]
107693599  protein Wnt-5a-like [KO:K00444]
107688914  protein Wnt-6-like [KO:K00445]
107660140  protein Wnt-6-like [KO:K00445]
107663826  protein Wnt-6-like [KO:K00445]
107672249  protein Wnt-6-like [KO:K00445]
107664847  protein Wnt-7b-like [KO:K00572]
107701192  protein Wnt-7b [KO:K00572]
107695867  protein Wnt-7b-like [KO:K00572]
107691337  protein Wnt-7a-like [KO:K00572]
107685644  protein Wnt-7a [KO:K00572]
107684886  protein Wnt-7a-like [KO:K00572]
107673931  protein Wnt-8b-like [KO:K00714]
107664328  protein Wnt-8a-like [KO:K00714]
107664333  protein Wnt-8a-like [KO:K00714]
107668784  protein Wnt-8b [KO:K00714]
107669111  protein Wnt-8a isoform X1 [KO:K00714]
107669112  protein Wnt-8a-like [KO:K00714]
107671764  protein Wnt-9a-like [KO:K01064]
107654519  protein Wnt-9b-like [KO:K01064]
107674619  protein Wnt-9b-like [KO:K01064]
107695810  protein Wnt-10b [KO:K01357]
107681943  protein Wnt-10b-like [KO:K01357]
107663825  protein Wnt-10a [KO:K01357]
107672309  protein Wnt-10a-like [KO:K01357]
107686210  protein Wnt-11-like [KO:K01384]
107691650  protein Wnt-11-like [KO:K01384]
107700898  protein Wnt-11-like [KO:K01384]
107655896  protein Wnt-11 [KO:K01384]
107656279  protein Wnt-16-like [KO:K01558]
107658764  protein Wnt-16-like [KO:K01558]
107677598  frizzled-7-A-like [KO:K02432]
107668396  frizzled-7-A [KO:K02432]
107660027  frizzled-7-A-like [KO:K02432]
107673352  frizzled-1-like [KO:K02432]
107659095  frizzled-1-like [KO:K02432]
107677792  fzd7; frizzled-7 [KO:K02432]
107658461  frizzled-2-like [KO:K02235]
107674136  frizzled-2-like [KO:K02235]
107696094  frizzled-3-like [KO:K02329]
107698353  frizzled-3-like [KO:K02329]
107665105  frizzled-3-like isoform X1 [KO:K02329]
107693021  frizzled-3-like [KO:K02329]
107689595  frizzled-4-like [KO:K02354]
107670140  fzd4; frizzled-4 [KO:K02354]
107698476  frizzled-8-like [KO:K02375]
107698527  frizzled-5-like [KO:K02375]
107663731  fzd8; frizzled-8 [KO:K02375]
107704794  frizzled-6-like [KO:K02376]
107669258  frizzled-10-B-like [KO:K02842]
107691792  frizzled-9 [KO:K02842]
107691950  frizzled-9-like [KO:K02842]
107659609  frizzled-10-B-like [KO:K02842]
107695150  frizzled-9-like [KO:K02842]
107684624  frizzled-9-like [KO:K02842]
107654131  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
107701357  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6-like [KO:K03068]
107701817  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
107680820  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
107655081  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
107670590  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107671749  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107656555  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
107695763  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
107681796  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107671937  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107683544  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
107685713  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
107675505  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
107661292  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107703010  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
107684292  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
107675878  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
107694347  tumor necrosis factor-like [KO:K03156]
107678132  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
107685522  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
107671968  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
107671012  inhibitor of nuclear factor kappa-B kinase subunit beta-like [KO:K07209] [EC:2.7.11.10]
107689667  insulin-like [KO:K04526]
107661260  ins; insulin isoform X1 [KO:K04526]
107663421  insulin-like [KO:K04526]
107663422  insulin-like [KO:K04526]
107666601  insulin-like [KO:K04526]
107664880  insulin-like growth factor I, adult form [KO:K05459]
107665064  insulin-like growth factor I isoform X1 [KO:K05459]
107659835  insulin-like growth factor I, adult form isoform X1 [KO:K05459]
107668948  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107695633  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107704428  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107659406  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107674748  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107672255  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107660938  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107704009  growth factor receptor-bound protein 2-like [KO:K04364]
107672691  growth factor receptor-bound protein 2 [KO:K04364]
107659857  growth factor receptor-bound protein 2-like [KO:K04364]
107672145  growth factor receptor-bound protein 2-like [KO:K04364]
107693017  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
107654947  son of sevenless homolog 2-like isoform X1 [KO:K03099]
107683816  son of sevenless homolog 2-like [KO:K03099]
107665896  son of sevenless homolog 1-like [KO:K03099]
107695370  GTPase HRas-like [KO:K02833]
107696631  GTPase HRas [KO:K02833]
107675668  GTPase HRas-like isoform X1 [KO:K02833]
107675296  GTPase HRas [KO:K02833]
107675271  ras-like protein isoform X1 [KO:K07827]
107675456  ras-like protein isoform X1 [KO:K07827]
107653435  GTPase HRas-like [KO:K07827]
107674363  GTPase NRas [KO:K07828]
107664995  GTPase HRas-like [KO:K07828]
107694295  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107655608  serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
107675968  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107687309  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107684881  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107686295  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107672217  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
107655207  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107676947  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107696522  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107676988  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107671813  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107668740  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107686994  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107690275  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107704570  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107687667  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
107666634  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
107672778  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
107674878  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
107660235  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
107654838  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
107663698  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
107702677  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
107688607  ribosomal protein S6 kinase alpha-6-like [KO:K04373] [EC:2.7.11.1]
107697698  ribosomal protein S6 kinase alpha-1-like isoform X1 [KO:K04373] [EC:2.7.11.1]
107683387  insulin receptor substrate 1-B-like [KO:K16172]
107704743  insulin receptor substrate 1-B-like [KO:K16172]
107675943  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107671741  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107688475  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
107661887  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107681053  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
107692397  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107684350  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
107680216  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
107653898  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107685965  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107671515  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
107695767  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
107655300  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
107677508  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107681979  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
107670848  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107680269  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107669198  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107689801  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107674683  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107703375  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107677174  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107667172  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
107703832  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107670243  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107666430  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107671613  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107678753  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107698756  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107703621  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107700803  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107692744  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107679018  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107676708  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107655432  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107666359  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
107666372  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
107654292  target of rapamycin complex 2 subunit MAPKAP1-like [KO:K20410]
107703559  rapamycin-insensitive companion of mTOR-like [KO:K08267]
107704198  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
107658248  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
107681152  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
107701358  prr5; proline-rich protein 5 [KO:K20411]
107696248  proline-rich protein 5-like [KO:K20411]
107661466  proline-rich protein 5-like isoform X1 [KO:K20411]
107661450  proline-rich protein 5-like [KO:K20411]
107696644  proline-rich protein 5-like [KO:K20411]
107696270  proline-rich protein 5-like isoform X1 [KO:K20411]
107668165  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107669667  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
107666088  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107687289  rho-related GTP-binding protein RhoA-C [KO:K04513]
107669674  rho-related GTP-binding protein RhoA-D-like isoform X1 [KO:K04513]
107704623  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
107705003  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107679717  rho-related GTP-binding protein RhoA-D [KO:K04513]
107665054  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
107679616  rho-related GTP-binding protein RhoA-B [KO:K04513]
107681330  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107700318  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
107694902  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
107698783  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
107664393  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
107692661  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107688094  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
107689613  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107702530  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
107672989  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
107692563  protein kinase C alpha type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
107702504  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
107671861  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
107672866  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
107701736  LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
107687822  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
sanh00561  Glycerolipid metabolism
sanh04010  MAPK signaling pathway
sanh04140  Autophagy - animal
sanh04810  Regulation of actin cytoskeleton
sanh04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

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