KEGG   PATHWAY: sanh04140
Entry
sanh04140                   Pathway                                
Name
Autophagy - animal - Sinocyclocheilus anshuiensis
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
sanh04140  Autophagy - animal
sanh04140

Other DBs
GO: 0006914
Organism
Sinocyclocheilus anshuiensis [GN:sanh]
Gene
107689667  insulin-like [KO:K04526]
107661260  ins; insulin isoform X1 [KO:K04526]
107663421  insulin-like [KO:K04526]
107663422  insulin-like [KO:K04526]
107666601  insulin-like [KO:K04526]
107674748  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107672255  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107660938  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107683387  insulin receptor substrate 1-B-like [KO:K16172]
107704743  insulin receptor substrate 1-B-like [KO:K16172]
107654267  insulin receptor substrate 2-like [KO:K07187]
107677836  insulin receptor substrate 2-B-like isoform X1 [KO:K07187]
107684954  insulin receptor substrate 2-B-like [KO:K07187]
107661701  insulin receptor substrate 2-A-like isoform X1 [KO:K07187]
107692954  insulin receptor substrate 2-B-like [KO:K07187]
107688717  insulin receptor substrate 2-like [KO:K07187]
107702923  insulin receptor substrate 2-like [KO:K07187]
107653898  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107685965  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107671515  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
107695767  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
107655300  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
107677508  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107681979  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
107675943  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107671741  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107688475  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
107661887  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107681053  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
107692397  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107684350  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
107680216  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
107674683  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107703375  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107677174  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107667172  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
107703832  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107670243  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107666430  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107671613  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107678753  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107698756  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107703621  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107700803  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107692744  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107679018  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107676708  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107670848  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107680269  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107669198  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107689801  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107695370  GTPase HRas-like [KO:K02833]
107696631  GTPase HRas [KO:K02833]
107675668  GTPase HRas-like isoform X1 [KO:K02833]
107675296  GTPase HRas [KO:K02833]
107675271  ras-like protein isoform X1 [KO:K07827]
107675456  ras-like protein isoform X1 [KO:K07827]
107653435  GTPase HRas-like [KO:K07827]
107674363  GTPase NRas [KO:K07828]
107664995  GTPase HRas-like [KO:K07828]
107700214  ras-related protein M-Ras [KO:K07831]
107663912  ras-related protein M-Ras isoform X1 [KO:K07831]
107663675  ras-related protein M-Ras-like [KO:K07831]
107653555  ras-related protein M-Ras-like [KO:K07831]
107688170  ras-related protein R-Ras2-like [KO:K07830]
107700612  ras-related protein R-Ras2 [KO:K07830]
107658490  ras-related protein R-Ras-like isoform X1 [KO:K07830]
107689668  ras-related protein R-Ras-like [KO:K07830]
107675968  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107687309  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107684881  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107686295  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107672217  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
107655207  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107676947  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107696522  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107676988  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107671813  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107668740  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107686994  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107690275  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107704570  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107701457  hypoxia-inducible factor 1-alpha-like [KO:K08268]
107697305  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
107675566  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
107668801  hypoxia-inducible factor 1-alpha-like [KO:K08268]
107685054  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
107664924  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
107659673  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
107688058  DNA damage-inducible transcript 4 protein-like [KO:K08270]
107703706  tuberin-like [KO:K07207]
107700795  LOW QUALITY PROTEIN: tuberin-like [KO:K07207]
107690665  hamartin-like isoform X1 [KO:K07206]
107686900  hamartin-like [KO:K07206]
107679850  tsc1; hamartin isoform X1 [KO:K07206]
107681228  hamartin-like isoform X1 [KO:K07206]
107704030  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
107668598  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
107671124  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
107654565  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
107653114  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
107694907  GTP-binding protein Rheb-like [KO:K07208]
107676829  GTP-binding protein Rheb [KO:K07208]
107653878  GTP-binding protein Rheb-like isoform X1 [KO:K07208]
107669526  regulatory-associated protein of mTOR-like [KO:K07204]
107701211  rptor; regulatory-associated protein of mTOR [KO:K07204]
107673035  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
107655034  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
107685573  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
107687131  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
107679101  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
107680841  proline-rich AKT1 substrate 1-like [KO:K16184]
107687628  uncharacterized protein LOC107687628 [KO:K16184]
107699873  target of rapamycin complex subunit lst8 [KO:K08266]
107669207  target of rapamycin complex subunit lst8-like [KO:K08266]
107699259  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107701421  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107659922  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107693887  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107700909  immunoglobulin-binding protein 1-like isoform X1 [KO:K17606]
107655913  immunoglobulin-binding protein 1-like [KO:K17606]
107661685  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107668574  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
107692973  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
107680607  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
107665468  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107684868  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
107692289  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
107659619  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
107661377  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
107684495  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
107657566  serine/threonine-protein kinase ULK2-like isoform X1 [KO:K08269] [EC:2.7.11.1]
107662799  serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
107677120  autophagy-related protein 13 isoform X1 [KO:K08331]
107703285  autophagy-related protein 13-like isoform X1 [KO:K08331]
107686213  autophagy-related protein 101 [KO:K19730]
107691654  autophagy-related protein 101-like [KO:K19730]
107677246  RB1-inducible coiled-coil protein 1-like isoform X1 [KO:K17589]
107663356  rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
107660800  LOW QUALITY PROTEIN: autophagy-related protein 2 homolog A-like [KO:K17906]
107664424  autophagy-related protein 2 homolog B-like [KO:K17906]
107698028  autophagy-related protein 2 homolog A-like isoform X1 [KO:K17906]
107664023  autophagy-related protein 2 homolog B-like isoform X1 [KO:K17906]
107674704  WD repeat domain phosphoinositide-interacting protein 2-like [KO:K17908]
107688112  WD repeat domain phosphoinositide-interacting protein 1-like isoform X1 [KO:K17908]
107703413  WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
107654490  WD repeat domain phosphoinositide-interacting protein 1-like isoform X1 [KO:K17908]
107670555  WD repeat domain phosphoinositide-interacting protein 3-like [KO:K22991]
107654004  WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
107658559  WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
107689948  WD repeat domain phosphoinositide-interacting protein 4-like [KO:K22991]
107677585  autophagy-related protein 9A-like [KO:K17907]
107660058  autophagy-related protein 9A-like [KO:K17907]
107690986  autophagy-related protein 9A-like [KO:K17907]
107677139  autophagy-related protein 9A-like [KO:K17907]
107697409  transcription factor SPT20 homolog isoform X1 [KO:K21245]
107686194  supt20h; transcription factor SPT20 homolog [KO:K21245]
107674654  Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog [KO:K23611]
107692669  Smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog [KO:K23611]
107702539  LOW QUALITY PROTEIN: Smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog [KO:K23611]
107703424  Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog isoform X1 [KO:K23611]
107662451  WD repeat-containing protein 41-like isoform X1 [KO:K23610]
107701940  WD repeat-containing protein 41-like isoform X1 [KO:K23610]
107666374  protein C9orf72-like [KO:K23609]
107695028  protein C9orf72-like [KO:K23609]
107687930  ras-related protein Rab-8A [KO:K07901]
107696202  ras-related protein Rab-8A-like [KO:K07901]
107704972  ras-related protein Rab-39B-like isoform X1 [KO:K07925]
107691951  ras-related protein Rab-39B-like [KO:K07925]
107673796  ras-related protein Rab-39B-like [KO:K07925]
107668897  ras-related protein Rab-39B-like [KO:K07925]
107684694  ras-related protein Rab-39B [KO:K07925]
107676448  sqstm1; sequestosome-1 [KO:K14381]
107663095  sequestosome-1-like isoform X1 [KO:K14381]
107658761  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
107662237  LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
107663824  TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
107676285  TRAF family member-associated NF-kappa-B activator-like isoform X1 [KO:K12650]
107700837  ras-related protein ORAB-1-like [KO:K07874]
107683438  ras-related protein ORAB-1-like [KO:K07874]
107666439  ras-related protein Rab-1A [KO:K07874]
107672095  ras-related protein ORAB-1-like [KO:K07874]
107676578  ras-related protein Rab-1A [KO:K07874]
107703793  ras-related protein ORAB-1-like [KO:K07874]
107701162  ras-related protein Rab-1A-like [KO:K07874]
107674885  ras-related GTP-binding protein A-like [KO:K16185]
107688597  ras-related GTP-binding protein A [KO:K16185]
107704952  ras-related GTP-binding protein C [KO:K16186]
107700741  ras-related GTP-binding protein C-like [KO:K16186]
107680791  ras-related GTP-binding protein D-like [KO:K16186]
107681629  ras-related GTP-binding protein C-like [KO:K16186]
107693082  ras-related GTP-binding protein D-like [KO:K16186]
107669953  ras-related GTP-binding protein C-like [KO:K16186]
107702084  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
107681921  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
107691024  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
107697327  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
107687345  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
107693840  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
107703755  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107661836  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
107671753  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107694605  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107670487  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
107658562  prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
107669012  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107660409  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107656045  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
107667398  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
107673500  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
107696837  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
107701924  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
107662288  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107673914  mitogen-activated protein kinase 8A isoform X1 [KO:K04440] [EC:2.7.11.24]
107667593  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107673832  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107693656  mitogen-activated protein kinase 8B-like [KO:K04440] [EC:2.7.11.24]
107668799  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107653969  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107671740  apoptosis regulator Bcl-2-like [KO:K02161]
107677290  apoptosis regulator Bcl-2-like [KO:K02161]
107697692  apoptosis regulator Bcl-2-like [KO:K02161]
107671991  bcl-2-like protein 1 [KO:K04570]
107657020  bcl-2-like protein 1 [KO:K04570]
107669322  bcl2-associated agonist of cell death-like [KO:K02158]
107691899  bcl2-associated agonist of cell death-like [KO:K02158]
107699975  bcl2-associated agonist of cell death-like [KO:K02158]
107669205  bcl2-associated agonist of cell death-like [KO:K02158]
107701795  becn1; beclin-1 [KO:K08334]
107695543  nuclear receptor-binding factor 2-like [KO:K21246]
107664428  nuclear receptor-binding factor 2-like [KO:K21246]
107654066  nuclear receptor-binding factor 2-like isoform X1 [KO:K21246]
107700663  phosphoinositide 3-kinase regulatory subunit 4-like [KO:K08333] [EC:2.7.11.1]
107704988  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
107691920  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
107668661  phosphatidylinositol 3-kinase catalytic subunit type 3-like [KO:K00914] [EC:2.7.1.137]
107689308  beclin 1-associated autophagy-related key regulator-like [KO:K17889]
107693176  beclin 1-associated autophagy-related key regulator-like isoform X1 [KO:K17889]
107656180  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
107670191  activating molecule in BECN1-regulated autophagy protein 1-like [KO:K17985]
107673272  activating molecule in BECN1-regulated autophagy protein 1-like [KO:K17985]
107694091  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107696643  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
107668420  tumor protein p53-inducible nuclear protein 2-like isoform X1 [KO:K21247]
107669700  tumor protein p53-inducible nuclear protein 2-like isoform X1 [KO:K21247]
107696618  tumor protein p53-inducible nuclear protein 2-like [KO:K21247]
107701424  vacuole membrane protein 1 [KO:K21248]
107659908  vmp1; vacuole membrane protein 1 [KO:K21248]
107657726  syntaxin-17-like [KO:K08491]
107687819  stx17; syntaxin-17 isoform X1 [KO:K08491]
107691651  UV radiation resistance-associated gene protein-like [KO:K21249]
107686127  UV radiation resistance-associated gene protein-like [KO:K21249]
107700566  endophilin-B1-like isoform X1 [KO:K11248]
107677249  endophilin-B1-like [KO:K11248]
107697708  endophilin-B1-like isoform X1 [KO:K11248]
107677816  endophilin-B1-like isoform X1 [KO:K11248]
107701215  run domain Beclin-1-interacting and cysteine-rich domain-containing protein-like [KO:K19330]
107679062  run domain Beclin-1-interacting and cysteine-rich domain-containing protein-like isoform X1 [KO:K19330]
107675640  camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
107662592  calcium/calmodulin-dependent protein kinase kinase 2-like [KO:K07359] [EC:2.7.11.17]
107683934  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
107665363  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
107653472  probable serine/threonine-protein kinase ireA isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107664531  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107692655  ern2; serine/threonine-protein kinase/endoribonuclease IRE2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107659569  serine/threonine-protein kinase ppk4-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107702527  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107701911  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107659525  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107673508  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
107685975  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107668980  dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
107680553  death-associated protein kinase 1-like [KO:K08803] [EC:2.7.11.1]
107659350  death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
107659496  death-associated protein kinase 2-like isoform X1 [KO:K08803] [EC:2.7.11.1]
107667793  death-associated protein kinase 2-like [KO:K08803] [EC:2.7.11.1]
107698309  dapk2; LOW QUALITY PROTEIN: death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
107656625  death-associated protein kinase 2-like [KO:K08803] [EC:2.7.11.1]
107700413  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
107700066  death-associated protein kinase 1-like [KO:K08803] [EC:2.7.11.1]
107653759  high mobility group protein B1-like [KO:K10802]
107704792  hmgb1; high mobility group protein B1 [KO:K10802]
107697437  high mobility group-T protein-like [KO:K10802]
107682836  high mobility group protein B1-like [KO:K10802]
107671339  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
107655313  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
107704056  eukaryotic translation initiation factor 2 subunit 1-like isoform X1 [KO:K03237]
107657741  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107669459  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107698017  myotubularin-related protein 3-like [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
107699659  myotubularin-related protein 3-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
107691163  myotubularin-related protein 3-like [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
107671008  myotubularin-related protein 3-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
107654282  mtmr4; myotubularin-related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
107666797  myotubularin-related protein 4-like [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
107688805  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
107691493  myotubularin-related protein 14-like [KO:K18086] [EC:3.1.3.64 3.1.3.95]
107668199  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
107678255  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
107672363  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
107659174  zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
107673043  ubiquitin-like protein ATG12 [KO:K08336]
107692547  ubiquitin-like protein ATG12 [KO:K08336]
107661007  autophagy protein 5-like isoform X1 [KO:K08339]
107697282  autophagy protein 5-like isoform X1 [KO:K08339]
107670107  autophagy-related protein 16-1-like isoform X1 [KO:K17890]
107689588  autophagy-related protein 16-1-like isoform X1 [KO:K17890]
107677090  autophagy-related protein 16-2-like isoform X1 [KO:K20868]
107667484  autophagy-related protein 16-2-like [KO:K20868]
107697561  ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
107687320  atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
107658540  ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
107689373  ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
107678229  ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
107659953  ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
107670324  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
107691294  CASP8 and FADD-like apoptosis regulator [KO:K04724]
107689499  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
107695070  CASP8 and FADD-like apoptosis regulator [KO:K04724]
107670889  ras-related protein Rab-33B-like [KO:K07920]
107674199  ras-related protein Rab-33B-like isoform X1 [KO:K07920]
107671374  ras-related protein Rab-33B-like [KO:K07920]
107680672  ras-related protein Rab-33B-like [KO:K07920]
107676515  ras-related protein Rab-33B-like [KO:K07920]
107663997  ras-related protein Rab-33B-like [KO:K07920]
107666947  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
107700204  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
107672985  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
107679910  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
107687670  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
107672762  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
107695954  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
107667682  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
107659131  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
107701564  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
107701141  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
107702025  microtubule-associated proteins 1A/1B light chain 3C-like isoform X1 [KO:K10435]
107691343  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
107680594  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
107685654  microtubule-associated proteins 1A/1B light chain 3A-like [KO:K10435]
107654145  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
107694120  cysteine protease ATG4B-like isoform X1 [KO:K08342] [EC:3.4.22.-]
107696340  cysteine protease ATG4D-like isoform X1 [KO:K08342] [EC:3.4.22.-]
107704517  cysteine protease ATG4C-like [KO:K08342] [EC:3.4.22.-]
107661698  cysteine protease ATG4A-like [KO:K08342] [EC:3.4.22.-]
107692955  cysteine protease ATG4A-like isoform X1 [KO:K08342] [EC:3.4.22.-]
107677346  cysteine protease ATG4D-like [KO:K08342] [EC:3.4.22.-]
107696761  cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
107675561  cysteine protease ATG4D-like [KO:K08342] [EC:3.4.22.-]
107684258  cysteine protease ATG4D-like [KO:K08342] [EC:3.4.22.-]
107692386  cysteine protease ATG4C-like [KO:K08342] [EC:3.4.22.-]
107666919  LOW QUALITY PROTEIN: next to BRCA1 gene 1 protein-like [KO:K17987]
107669491  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
107689639  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
107658519  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
107656330  optineurin-like [KO:K19946]
107658854  optineurin [KO:K19946]
107660853  calcium-binding and coiled-coil domain-containing protein 2-like [KO:K21348]
107692041  calcium-binding and coiled-coil domain-containing protein 2-like [KO:K21348]
107654769  tax1-binding protein 1 homolog A [KO:K21347]
107685538  tax1-binding protein 1 homolog B-like isoform X1 [KO:K21347]
107684534  tax1-binding protein 1 homolog B isoform X1 [KO:K21347]
107688347  LOW QUALITY PROTEIN: tax1-binding protein 1 homolog A-like [KO:K21347]
107681281  WD repeat and FYVE domain-containing protein 3-like [KO:K22262]
107661255  WD repeat and FYVE domain-containing protein 3 [KO:K22262]
107696297  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
107694989  ubiquitin-like isoform X1 [KO:K02927]
107660378  ubiquitin-60S ribosomal protein L40 [KO:K02927]
107678226  ubiquitin-40S ribosomal protein S27a [KO:K02977]
107672676  ubiquitin-40S ribosomal protein S27a [KO:K02977]
107657202  synaptosomal-associated protein 29-like [KO:K08509]
107671027  snap29; synaptosomal-associated protein 29 isoform X1 [KO:K08509]
107702596  vesicle-associated membrane protein 8-like [KO:K08512]
107656490  vesicle-associated membrane protein 8-like [KO:K08512]
107673438  vesicle-associated membrane protein 8-like [KO:K08512]
107653492  vesicle-associated membrane protein 8-like [KO:K08512]
107704135  synaptobrevin homolog YKT6 isoform X1 [KO:K08516]
107665783  synaptobrevin homolog YKT6-like [KO:K08516]
107697113  syntaxin-7-like [KO:K08488]
107685381  syntaxin-7-like [KO:K08488]
107697515  ectopic P granules protein 5 homolog [KO:K23883]
107676662  ectopic P granules protein 5 homolog [KO:K23883]
107681055  ectopic P granules protein 5 homolog [KO:K23883]
107654030  pleckstrin homology domain-containing family M member 1-like [KO:K23282]
107664630  pleckstrin homology domain-containing family M member 1-like [KO:K23282]
107691631  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
107693978  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
107659985  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
107668247  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
107659178  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
107662044  vacuolar protein sorting-associated protein 33A [KO:K20182]
107702975  vacuolar protein sorting-associated protein 33A-like [KO:K20182]
107687842  vam6/Vps39-like protein [KO:K20183]
107687939  vam6/Vps39-like protein isoform X1 [KO:K20183]
107696497  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
107691426  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
107670830  baculoviral IAP repeat-containing protein 6-like [KO:K10586] [EC:2.3.2.23]
107689818  baculoviral IAP repeat-containing protein 6-like [KO:K10586] [EC:2.3.2.23]
107676822  gorasp1; Golgi reassembly-stacking protein 1 [KO:K26797]
107688453  Golgi reassembly-stacking protein 1-like isoform X1 [KO:K26797]
107689416  Golgi reassembly-stacking protein 1-like [KO:K26797]
107672644  gorasp2; Golgi reassembly-stacking protein 2 [KO:K26797]
107658609  ras-related protein Rab-7a [KO:K07897]
107689338  ras-related protein Rab-7a-like [KO:K07897]
107678421  ras-related protein Rab-7a-like [KO:K07897]
107665199  ras-related protein Rab-7a-like [KO:K07897]
107655032  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
107685683  ras-related protein Rab-7a-like [KO:K07897]
107655959  ras-related protein Rab-7a-like [KO:K07897]
107673715  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
107694471  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
107695490  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
107664338  lysosome-associated membrane glycoprotein 2-like isoform X1 [KO:K06528]
107654559  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
107658136  lysosome-associated membrane glycoprotein 2-like isoform X1 [KO:K06528]
107672139  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
107686244  cathepsin D [KO:K01379] [EC:3.4.23.5]
107695135  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
107672285  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
107653645  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107687684  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107680563  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107672789  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107669798  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107697653  uncharacterized protein LOC107697653 [KO:K01365] [EC:3.4.22.15]
107700067  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107674100  ctsb; cathepsin B [KO:K01363] [EC:3.4.22.1]
107661356  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
sanh04010  MAPK signaling pathway
sanh04141  Protein processing in endoplasmic reticulum
sanh04142  Lysosome
sanh04150  mTOR signaling pathway
sanh04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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