KEGG   PATHWAY: sbq04640
Entry
sbq04640                    Pathway                                
Name
Hematopoietic cell lineage - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
sbq04640  Hematopoietic cell lineage
sbq04640

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101047247  KITLG; kit ligand isoform X1 [KO:K05461]
101048813  IL7; interleukin-7 [KO:K05431]
101038267  IL4; interleukin-4 isoform X1 [KO:K05430]
101043583  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
101030168  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
101039737  IL5; interleukin-5 [KO:K05428]
101040223  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
101043897  IL3; interleukin-3 [KO:K04736]
101034757  IL6; interleukin-6 [KO:K05405]
101048956  IL11; interleukin-11 isoform X1 [KO:K05417]
101033360  IL1A; interleukin-1 alpha [KO:K04383]
101033664  IL1B; interleukin-1 beta [KO:K04519]
101031357  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101036115  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101049694  EPO; erythropoietin isoform X1 [KO:K05437]
101047352  THPO; LOW QUALITY PROTEIN: thrombopoietin [KO:K06854]
101043446  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
101027591  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101034366  DNTT; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:2.7.7.31]
101053828  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X2 [KO:K06752]
101054155  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
101053201  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X4 [KO:K06752]
101054478  HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1 [KO:K06752]
101052879  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101034517  HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1 [KO:K06752]
101041326  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101034208  HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
101041640  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
101038711  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
104650606  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101039757  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101039220  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
101040088  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
101052651  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
101052977  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
101028425  CD44; CD44 antigen isoform X2 [KO:K06256]
101037282  KIT; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
101036589  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
101044161  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101030435  TFRC; transferrin receptor protein 1 [KO:K06503]
101036203  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101044532  CD7; T-cell antigen CD7 isoform X1 [KO:K06457]
101044198  CD2; T-cell surface antigen CD2 [KO:K06449]
101046234  CD5; T-cell surface glycoprotein CD5 [KO:K06455]
104652882  T-cell surface glycoprotein CD1a-like [KO:K06448]
101046248  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
101045925  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
101044987  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
101028824  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
101045342  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
101044254  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X3 [KO:K06459]
101029738  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
101030803  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
101029105  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
101046081  MME; neprilysin isoform X2 [KO:K01389] [EC:3.4.24.11]
101043840  CD9; CD9 antigen [KO:K06460]
101048436  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
101031827  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
101029424  CD24; signal transducer CD24 [KO:K06469]
101042514  MS4A1; B-lymphocyte antigen CD20 isoform X1 [KO:K06466]
101045483  CR2; complement receptor type 2 isoform X2 [KO:K04012]
101028472  CD37; leukocyte antigen CD37 isoform X4 [KO:K06475]
101040997  LOW QUALITY PROTEIN: putative V-set and immunoglobulin domain-containing protein 7 [KO:K06856]
101054381  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
101033685  uncharacterized protein LOC101033685 [KO:K06856]
101041646  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
101046577  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
104651759  CR1L; complement component receptor 1-like protein isoform X1 [KO:K04011]
101048758  CR1; complement receptor type 1 [KO:K04011]
101038788  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
101039092  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
101044930  CD33; myeloid cell surface antigen CD33 isoform X2 [KO:K06473]
101044733  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101037958  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101027415  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
101043573  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101037850  ANPEP; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
101035688  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101051835  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101038590  IL9R; interleukin-9 receptor [KO:K05073]
101031937  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101032260  IL1R2; LOW QUALITY PROTEIN: interleukin-1 receptor type 2 [KO:K04387]
101042318  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101032072  IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067]
101035236  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
101043591  CD36; platelet glycoprotein 4 [KO:K06259]
101039474  GYPA; glycophorin-A isoform X1 [KO:K06575]
101046326  CD55; complement decay-accelerating factor [KO:K04006]
101029073  CD59; CD59 glycoprotein [KO:K04008]
101035136  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
101049562  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
101031876  ITGA2B; integrin alpha-IIb [KO:K06476]
101044256  GP9; platelet glycoprotein IX [KO:K06263]
101033397  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
104650035  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
101049885  GP5; platelet glycoprotein V [KO:K06260]
101041823  ITGA1; integrin alpha-1 [KO:K06480]
101041311  ITGA2; integrin alpha-2 [KO:K06481]
101050876  ITGA3; integrin alpha-3 [KO:K06482]
101048275  ITGA4; integrin alpha-4 [KO:K06483]
101043820  ITGA5; integrin alpha-5 [KO:K06484]
101045102  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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