KEGG   PATHWAY: sjo00260
Entry
sjo00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Scomber japonicus (chub mackerel)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sjo00260  Glycine, serine and threonine metabolism
sjo00260

Module
sjo_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sjo00260]
sjo_M00047  Creatine pathway [PATH:sjo00260]
sjo_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sjo00260]
sjo_M00555  Betaine biosynthesis, choline => betaine [PATH:sjo00260]
sjo_M00621  Glycine cleavage system [PATH:sjo00260]
sjo_M00974  Betaine metabolism, animals, betaine => glycine [PATH:sjo00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Scomber japonicus (chub mackerel) [GN:sjo]
Gene
128381635  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
128355570  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
128378508  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
128356960  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
128368498  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
128361682  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
128362521  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
128377700  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
128355089  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
128380208  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
128369734  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
128373160  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
128358446  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
128368077  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
128364161  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
128360358  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
128378282  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
128375170  tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
128354199  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
128357764  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
128357961  5-aminolevulinate synthase, non-specific, mitochondrial-like isoform X1 [KO:K00643] [EC:2.3.1.37]
128355836  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
128368458  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
128380357  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
128379627  primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]
128378641  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
128365367  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
128357896  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
128359160  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
128362705  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
128358684  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
128364378  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
128380541  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
128380545  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
128358819  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
128361605  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
128357132  chdh; choline dehydrogenase, mitochondrial isoform X1 [KO:K00108] [EC:1.1.99.1]
128361575  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
128380740  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
128364714  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
128364715  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
128364815  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
128365203  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
128380734  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
128360802  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
128380397  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
128375518  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
128354415  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
128367653  cbsb; cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
128361352  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
128373357  uncharacterized protein LOC128373357 [KO:K01754] [EC:4.3.1.19]
128375517  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
128365120  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
128368875  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sjo00010  Glycolysis / Gluconeogenesis
sjo00020  Citrate cycle (TCA cycle)
sjo00230  Purine metabolism
sjo00250  Alanine, aspartate and glutamate metabolism
sjo00270  Cysteine and methionine metabolism
sjo00290  Valine, leucine and isoleucine biosynthesis
sjo00330  Arginine and proline metabolism
sjo00470  D-Amino acid metabolism
sjo00564  Glycerophospholipid metabolism
sjo00600  Sphingolipid metabolism
sjo00620  Pyruvate metabolism
sjo00630  Glyoxylate and dicarboxylate metabolism
sjo00640  Propanoate metabolism
sjo00860  Porphyrin metabolism
sjo00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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