KEGG   PATHWAY: slal00600
Entry
slal00600                   Pathway                                
Name
Sphingolipid metabolism - Seriola lalandi dorsalis (Yellowtail amberjack)
Class
Metabolism; Lipid metabolism
Pathway map
slal00600  Sphingolipid metabolism
slal00600

Module
slal_M00066  Lactosylceramide biosynthesis [PATH:slal00600]
slal_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:slal00600]
slal_M00094  Ceramide biosynthesis [PATH:slal00600]
slal_M00099  Sphingosine biosynthesis [PATH:slal00600]
slal_M00100  Sphingosine degradation [PATH:slal00600]
Other DBs
GO: 0006665
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111650248  sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
111648057  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
111673710  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
111672668  sptlc2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
111670501  kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
111650208  cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
111671075  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
111652195  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
111650211  ceramide synthase 2-like isoform X1 [KO:K24621] [EC:2.3.1.297]
111657618  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
111644372  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
111653318  ceramide synthase 2-like isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
111654505  cers6; ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
111667195  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
111648435  cers5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
111663285  asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
111655115  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
111664095  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
111645351  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
111663550  acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
111644804  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
111669504  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
111670025  sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
111661049  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
111671165  sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
111666212  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
111662345  smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
111647791  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
111652731  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
111666810  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
111672863  smpd4; sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
111646926  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
111664324  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like isoform X1 [KO:K12354] [EC:3.1.4.12]
111648577  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
111650289  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
111665078  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
111670741  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
111667351  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
111654295  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
111666537  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
111656803  LOW QUALITY PROTEIN: phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
111653698  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
111665198  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
111645125  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
111665514  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
111673079  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
111654330  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
111652673  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
111671281  sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
111659689  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
111647507  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
111652178  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
111669498  sgpl1; sphingosine-1-phosphate lyase 1 isoform X1 [KO:K01634] [EC:4.1.2.27]
111651594  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
111652186  gba; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
111647183  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
111671660  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
111668978  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
111670397  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
111664066  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
111667257  galc; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
111660255  gal3st1; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
111664815  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
111659686  galactosylceramide sulfotransferase-like isoform X1 [KO:K01019] [EC:2.8.2.11]
111671239  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
111651719  neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
111664479  sialidase-4-like [KO:K12357] [EC:3.2.1.18]
111666140  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
111654126  neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
111664518  sialidase-4-like [KO:K12357] [EC:3.2.1.18]
111648206  gla; alpha-galactosidase A isoform X1 [KO:K01189] [EC:3.2.1.22]
111667834  b4galnt1; beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
111668982  beta-1,4 N-acetylgalactosaminyltransferase 1-like isoform X1 [KO:K00725] [EC:2.4.1.92]
111667026  hexa; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
111653965  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
111666815  hexb; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
111662564  gm2a; ganglioside GM2 activator [KO:K12383]
111669443  prosaposin-like isoform X1 [KO:K12382]
111658229  prosaposin-like [KO:K12382]
111655169  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
slal00260  Glycine, serine and threonine metabolism
slal00601  Glycosphingolipid biosynthesis - lacto and neolacto series
slal00603  Glycosphingolipid biosynthesis - globo and isoglobo series
slal00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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