KEGG   PATHWAY: slal04137
Entry
slal04137                   Pathway                                
Name
Mitophagy - animal - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
slal04137  Mitophagy - animal
slal04137

Other DBs
GO: 0000422
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111666039  LOW QUALITY PROTEIN: activating molecule in BECN1-regulated autophagy protein 1-like [KO:K17985]
111669380  pink1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
111659237  tomm7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
111657251  tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
111661086  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
111666171  mitochondrial import receptor subunit TOM40B-like [KO:K11518]
111651189  mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
111659014  tomm20; mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
111660166  tomm70; mitochondrial import receptor subunit TOM70 [KO:K17768]
111656069  prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
111664465  E3 ubiquitin-protein ligase MARCH5-like isoform X1 [KO:K10660] [EC:2.3.2.27]
111669477  march5; E3 ubiquitin-protein ligase MARCH5 [KO:K10660] [EC:2.3.2.27]
111647918  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111666015  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111664872  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111659714  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
111646327  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
111673792  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
111653408  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
111659140  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
111654415  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
111670239  mitochondrial ubiquitin ligase activator of NFKB 1-like [KO:K15688] [EC:2.3.2.27]
111669378  mul1; mitochondrial ubiquitin ligase activator of NFKB 1 [KO:K15688] [EC:2.3.2.27]
111666559  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
111670662  huwe1; E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
111654943  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
111666902  arih1; E3 ubiquitin-protein ligase ARIH1 [KO:K11968] [EC:2.3.2.31]
111670228  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
111650203  mfn1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
111670657  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
111650953  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
111645821  mitochondrial Rho GTPase 1-A isoform X1 [KO:K07870] [EC:3.6.5.-]
111658736  rhot2; mitochondrial Rho GTPase 2 [KO:K07871] [EC:3.6.5.-]
111649938  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
111645827  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
111671125  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
111648910  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
111664718  ubb; polyubiquitin-B [KO:K04551]
111663901  ubc; polyubiquitin-C [KO:K08770]
111652719  tax1-binding protein 1 homolog B-like [KO:K21347]
111673316  tax1-binding protein 1 homolog B-like [KO:K21347]
111665615  sequestosome-1-like isoform X1 [KO:K14381]
111655399  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
111667339  optn; optineurin [KO:K19946]
111656144  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
111667213  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
111671054  tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
111656635  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
111650701  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
111669946  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
111647741  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
111655733  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
111655782  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
111670232  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
111644392  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
111657136  becn1; beclin-1 [KO:K08334]
111656875  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
111651981  usp15; ubiquitin carboxyl-terminal hydrolase 15 isoform X1 [KO:K21343] [EC:3.4.19.12]
111660240  usp30; ubiquitin carboxyl-terminal hydrolase 30 isoform X1 [KO:K11851] [EC:3.4.19.12]
111649248  bcl-2-like protein 1 [KO:K04570]
111661912  bcl2l1; bcl-2-like protein 1 [KO:K04570]
111647886  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
111668630  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
111656633  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
111664942  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
111658769  csnk2a2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
111651727  casein kinase II subunit beta [KO:K03115]
111664932  casein kinase II subunit beta [KO:K03115]
111660679  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111644184  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111645045  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
111655639  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
111644561  FUN14 domain-containing protein 1-like [KO:K17986]
111646208  FUN14 domain-containing protein 1 isoform X1 [KO:K17986]
111656778  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
111649552  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
111650127  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
111645058  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
111666093  bcl-2-like protein 13 [KO:K15485]
111656396  fkbp8; peptidyl-prolyl cis-trans isomerase FKBP8 [KO:K09574] [EC:5.2.1.8]
111666870  peptidyl-prolyl cis-trans isomerase FKBP8-like [KO:K09574] [EC:5.2.1.8]
111650328  sorting and assembly machinery component 50 homolog A isoform X1 [KO:K07277]
111664240  samm50; sorting and assembly machinery component 50 homolog [KO:K07277]
111649664  prohibitin-2-like [KO:K17081]
111656948  prohibitin-2-like [KO:K17081]
111662555  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
111660261  mtx3; metaxin-3 isoform X1 [KO:K17776]
111646924  metaxin-1-like [KO:K17776]
111644596  mtx2; metaxin-2 [KO:K17776]
111646809  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
111661486  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
111646360  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
111671828  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
111656807  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111658196  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111664771  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111646556  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111666541  jun; transcription factor AP-1 [KO:K04448]
111671973  transcription factor AP-1-like isoform X1 [KO:K04448]
111648134  transcription factor AP-1-like [KO:K04448]
111670446  rela; transcription factor p65 isoform X1 [KO:K04735]
111661823  hras; GTPase HRas [KO:K02833]
111649083  GTPase HRas-like [KO:K07827]
111655355  kras; GTPase KRas isoform X1 [KO:K07827]
111667451  mras; ras-related protein M-Ras [KO:K07831]
111655614  rras; ras-related protein R-Ras [KO:K07830]
111654503  rras2; ras-related protein R-Ras2 [KO:K07830]
111659477  ras-related protein R-Ras2-like [KO:K07830]
111655259  e2f1; transcription factor E2F1 [KO:K17454]
111655237  epas1; endothelial PAS domain-containing protein 1 isoform X1 [KO:K08268]
111651106  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
111657960  hypoxia-inducible factor 3-alpha-like isoform X1 [KO:K08268]
111670201  sp1; transcription factor Sp1 [KO:K04684]
111650698  cellular tumor antigen p53-like [KO:K04451]
111658316  foxo3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
111665879  forkhead box protein O3-like [KO:K09408]
111660073  forkhead box protein O6-like [KO:K09408]
111653185  microphthalmia-associated transcription factor-like [KO:K09455]
111655002  mitf; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
111667758  transcription factor EB-like isoform X1 [KO:K15590]
111654971  transcription factor E3-like [KO:K09105]
111649271  tfe3; transcription factor E3 [KO:K09105]
111658224  rab5 GDP/GTP exchange factor-like [KO:K20131]
111654388  rab5 GDP/GTP exchange factor-like [KO:K20131]
111659960  rabgef1; rab5 GDP/GTP exchange factor [KO:K20131]
111659338  ras-related protein Rab-5A [KO:K07887]
111652636  ras-related protein Rab-5A [KO:K07887]
111659545  ras-related protein Rab-5B-like [KO:K07888]
111652822  rab5c; ras-related protein Rab-5C [KO:K07889]
111665760  ras-related protein Rab-5C-like [KO:K07889]
111657106  ras-related protein Rab-5C-like [KO:K07889]
111653809  vacuolar fusion protein MON1 homolog B-like isoform X1 [KO:K20195]
111653198  mon1a; vacuolar fusion protein MON1 homolog A [KO:K20195]
111648896  vacuolar fusion protein MON1 homolog B-like [KO:K20195]
111672040  ccz1; vacuolar fusion protein CCZ1 homolog [KO:K27045]
111670680  ras-related protein Rab-7a-like [KO:K07897]
111649239  ras-related protein rab7-like [KO:K07897]
111667766  ras-related protein rab7-like [KO:K07897]
111670952  ras-related protein rab7 [KO:K07897]
111652856  tbc1d15; LOW QUALITY PROTEIN: TBC1 domain family member 15 [KO:K20168]
111660509  tbc1d17; TBC1 domain family member 17 [KO:K19945]
111647137  fis1; mitochondrial fission 1 protein [KO:K17969]
111653264  autophagy-related protein 9A-like [KO:K17907]
111649389  atg9a; autophagy-related protein 9A [KO:K17907]
111665235  autophagy-related protein 9A-like [KO:K17907]
111651414  opa1; dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
111660300  vcp; transitional endoplasmic reticulum ATPase [KO:K13525]
111665541  transitional endoplasmic reticulum ATPase-like [KO:K13525]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
slal04140  Autophagy - animal
slal04210  Apoptosis
KO pathway
ko04137   
LinkDB

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