KEGG   PATHWAY: sluc04520
Entry
sluc04520                   Pathway                                
Name
Adherens junction - Sander lucioperca (pikeperch)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
sluc04520  Adherens junction
sluc04520

Other DBs
GO: 0005912
Organism
Sander lucioperca (pikeperch) [GN:sluc]
Gene
116046963  si:ch211-214p13.3; nectin-3 isoform X2 [KO:K06081]
116065007  nectin1a; nectin cell adhesion molecule 1a isoform X1 [KO:K06081]
116041182  nectin1b; nectin cell adhesion molecule 1b isoform X1 [KO:K06081]
116049756  si:ch73-22o12.1; nectin-2 isoform X1 [KO:K06531]
116047077  pvrl2l; PVR cell adhesion molecule related 2 like isoform X1 [KO:K06531]
116064820  nectin3b; nectin-3-like protein isoform X1 [KO:K06592]
116048458  nectin3a; nectin-3-like protein isoform X1 [KO:K06592]
116042355  nectin4a; nectin-4 [KO:K06593]
116048831  nectin4b; nectin-4 isoform X1 [KO:K06593]
116044926  pard3ab; par-3 family cell polarity regulator alpha, b isoform X2 [KO:K04237]
116064851  partitioning defective 3 homolog isoform X1 [KO:K04237]
116043666  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116051428  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
116063285  farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
116049717  cdc42l; cell division cycle 42, like [KO:K04393]
116043633  cell division control protein 42 homolog isoform X1 [KO:K04393]
116046410  cell division control protein 42 homolog [KO:K04393]
116055515  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116059713  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116044236  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116042633  rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116067499  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
116041680  si:dkey-197j19.6; neural Wiskott-Aldrich syndrome protein [KO:K23612]
116060063  waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
116036271  wasla; WASP like actin nucleation promoting factor a isoform X2 [KO:K23612]
116043492  wasb; WASP actin nucleation promoting factor b isoform X1 [KO:K05747]
116067267  iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
116049612  zgc:158689; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
116059618  baiap2a; brain-specific angiogenesis inhibitor 1-associated protein 2a isoform X2 [KO:K05627]
116061016  baiap2b; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
116066137  wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
116066890  wasf2; wiskott-Aldrich syndrome protein family member 2 isoform X1 [KO:K05748]
116049146  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
116053180  zgc:109889; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
116037846  wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
116064999  wasf3a; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
116066295  afdna; afadin isoform X10 [KO:K05702]
116057291  afadin isoform X1 [KO:K05702]
116042500  lmo7a; LIM domain only protein 7 isoform X1 [KO:K06084]
116067754  LIM domain only protein 7-like isoform X3 [KO:K06084]
116042581  si:ch211-286b5.4; afadin- and alpha-actinin-binding protein B isoform X1 [KO:K06085]
116046213  ssx2ipa; synovial sarcoma, X breakpoint 2 interacting protein a [KO:K06085]
116055248  afadin- and alpha-actinin-binding protein isoform X3 [KO:K06085]
116039373  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
116053189  actn4; alpha-actinin-4 isoform X3 [KO:K05699]
116057405  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
116052919  vinculin-like isoform X1 [KO:K05700]
116061149  vinculin isoform X1 [KO:K05700]
116038332  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
116034026  tjp1a; tight junction protein ZO-1 isoform X13 [KO:K05701]
116041154  cadherin-23-like [KO:K05689]
116047882  B-cadherin-like isoform X1 [KO:K05689]
116047883  B-cadherin-like [KO:K05689]
116052424  catenin delta-1 isoform X3 [KO:K05690]
116039563  ctnnd1; catenin delta-1 isoform X2 [KO:K05690]
116066918  catenin beta-1-like [KO:K02105]
116035276  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
116052230  ctnna2; catenin alpha-2 isoform X1 [KO:K05691]
116064496  ctnna1; catenin alpha-1 [KO:K05691]
116042675  actb1; actin, cytoplasmic 1 [KO:K05692]
116065273  actb2; actin, cytoplasmic 2 [KO:K05692]
116058705  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
116051439  rhoca; ras homolog family member Ca isoform X1 [KO:K04513]
116041618  rho-related GTP-binding protein RhoA-B [KO:K04513]
116038421  rho-related GTP-binding protein RhoA-D [KO:K04513]
116040854  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
116066161  acp1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
116057846  receptor-type tyrosine-protein phosphatase mu-like isoform X1 [KO:K05693] [EC:3.1.3.48]
116045857  receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
116051995  receptor-type tyrosine-protein phosphatase beta isoform X1 [KO:K05694] [EC:3.1.3.48]
116061872  receptor-type tyrosine-protein phosphatase beta-like isoform X1 [KO:K05694] [EC:3.1.3.48]
116058934  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
116045884  receptor-type tyrosine-protein phosphatase F isoform X3 [KO:K05695] [EC:3.1.3.48]
116043599  tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
116049713  ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
116038375  ptprjb.1; receptor-type tyrosine-protein phosphatase eta isoform X2 [KO:K05698] [EC:3.1.3.48]
116049363  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
116057803  csnk2a2b; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
116067291  csnk2a2a; casein kinase 2, alpha prime polypeptide a [KO:K03097] [EC:2.7.11.1]
116034502  csnk2a4; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
116049371  casein kinase II subunit beta [KO:K03115]
116047268  csnk2b; casein kinase II subunit beta [KO:K03115]
118493643  transcription factor 7-like [KO:K02620]
116055911  tcf7; transcription factor 7 isoform X1 [KO:K02620]
116041786  transcription factor 7-like 1-B [KO:K04490]
116053887  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
116061043  tcf7l2; transcription factor 7-like 2 isoform X2 [KO:K04491]
116034295  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
116045678  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116057296  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116045912  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
116055274  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
116036253  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116046206  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116056499  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
116061112  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116050569  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
116041780  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
116050702  fibroblast growth factor receptor 1-like [KO:K04362] [EC:2.7.10.1]
116037483  tyrosine-protein kinase Fer-like isoform X1 [KO:K08889] [EC:2.7.10.2]
116040292  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
116057484  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
116045280  tyrosine-protein kinase yes [KO:K05705] [EC:2.7.10.2]
116045945  yes1; tyrosine-protein kinase yes [KO:K05705] [EC:2.7.10.2]
116054032  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116065226  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116045995  snai2; zinc finger protein SNAI2 [KO:K05706]
116035882  snai1a; snail family zinc finger 1a [KO:K05707]
116062219  snai1b; snail family zinc finger 1b [KO:K05707]
116065006  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
116066638  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
116046615  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
116047287  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116043529  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
116038466  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
116035687  si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
116056835  mothers against decapentaplegic homolog 4-like [KO:K04501]
116034988  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
116059312  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
116065293  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
116042960  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116048733  ep300a; histone acetyltransferase p300 isoform X9 [KO:K04498] [EC:2.3.1.48]
116040316  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116065811  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
116059058  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
116060875  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
116061709  cdh5; cadherin-5 [KO:K06533]
116037747  heg1; protein HEG [KO:K24472]
116047365  krit1; krev interaction trapped protein 1 [KO:K17705]
116065967  ccm2; cerebral cavernous malformations protein 2 homolog isoform X1 [KO:K26416]
116043828  pdcd10a; programmed cell death protein 10-A [KO:K18269]
116057359  programmed cell death protein 10 [KO:K18269]
116043036  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
116065242  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
116065443  E3 ubiquitin-protein ligase SMURF2 isoform X2 [KO:K04678] [EC:2.3.2.26]
116051393  ras-related protein Rap-1A [KO:K04353]
116043610  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
116047935  ras-related protein Rap-1b [KO:K07836]
116049647  rasip1; ras-interacting protein 1 isoform X1 [KO:K26417]
116044127  ras-associating and dilute domain-containing protein-like isoform X1 [KO:K26418]
116043017  radil; ras-associating and dilute domain-containing protein isoform X1 [KO:K26418]
116063868  si:ch73-281f12.4; RA_Radil_like and Myo5p-like_CBD_Rasip1 domain-containing protein isoform X1 [KO:K26418]
116045864  rho GTPase-activating protein 29-like isoform X1 [KO:K20644]
116055759  arhgap29a; rho GTPase-activating protein 29 isoform X1 [KO:K20644]
116046203  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116066412  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
116065683  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116051677  myl2b; myosin, light chain 2b, regulatory, cardiac, slow isoform X1 [KO:K10351]
116034528  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
116041874  myosin light chain 5-like [KO:K12753]
116054285  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
116034107  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
116045254  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
116045953  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
116061413  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
116063865  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
Reference
PMID:15001769
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
DOI:10.1126/science.1094291
Reference
PMID:10204118
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
DOI:10.1210/edrv.20.2.0362
Reference
PMID:10959047
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
DOI:10.1016/S0959-8049(00)00158-1
Reference
PMID:15489912
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
DOI:10.1038/sj.onc.1208161
Reference
PMID:11171368
  Authors
Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
PMID:11984870
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
DOI:10.1002/dvdy.10087
Reference
PMID:12640114
  Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
DOI:10.1128/MCB.23.7.2287-2297.2003
Reference
PMID:14623871
  Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
  Journal
J Cell Biol 163:847-57 (2003)
DOI:10.1083/jcb.200308162
Reference
PMID:11703922
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
DOI:10.1016/S1534-5807(01)00017-X
Reference
PMID:12665527
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
DOI:10.1074/jbc.M211304200
Reference
PMID:10890911
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
  Journal
Proc Natl Acad Sci U S A 97:8358-63 (2000)
DOI:10.1073/pnas.150152697
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Related
pathway
sluc04010  MAPK signaling pathway
sluc04060  Cytokine-cytokine receptor interaction
sluc04310  Wnt signaling pathway
sluc04350  TGF-beta signaling pathway
sluc04530  Tight junction
sluc04810  Regulation of actin cytoskeleton
KO pathway
ko04520   
LinkDB

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