KEGG   PATHWAY: sstn04144
Entry
sstn04144                   Pathway                                
Name
Endocytosis - Solanum stenotomum
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
sstn04144  Endocytosis
sstn04144

Other DBs
GO: 0006897
Organism
Solanum stenotomum [GN:sstn]
Gene
125863620  phosphatidylinositol 4-phosphate 5-kinase 9-like [KO:K00889] [EC:2.7.1.68]
125877200  phosphatidylinositol 4-phosphate 5-kinase 7-like [KO:K00889] [EC:2.7.1.68]
125865083  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
125866332  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
125866443  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
125856136  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
125871839  phosphatidylinositol 4-phosphate 5-kinase 9-like isoform X1 [KO:K00889] [EC:2.7.1.68]
125844897  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
125861769  phosphatidylinositol 4-phosphate 5-kinase 6-like isoform X1 [KO:K00889] [EC:2.7.1.68]
125862752  phospholipase D gamma 1-like [KO:K01115] [EC:3.1.4.4]
125864438  phospholipase D gamma 1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
125865061  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
125853036  phospholipase D zeta 1-like [KO:K01115] [EC:3.1.4.4]
125853717  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
125867260  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
125854369  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
125841367  phospholipase D beta 1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
125857928  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
125842624  phospholipase D alpha 1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
125860178  phospholipase D alpha 4 [KO:K01115] [EC:3.1.4.4]
125860380  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
125874076  LOW QUALITY PROTEIN: phospholipase D zeta 1-like [KO:K01115] [EC:3.1.4.4]
125874253  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
125846666  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
125853329  dynamin-2A [KO:K01528] [EC:3.6.5.5]
125845291  dynamin-2A-like [KO:K01528] [EC:3.6.5.5]
125875211  clathrin heavy chain 1 [KO:K04646]
125869205  clathrin heavy chain 1-like [KO:K04646]
125860731  clathrin heavy chain 1-like [KO:K04646]
125843815  AP-2 complex subunit alpha-1-like isoform X1 [KO:K11824]
125873200  AP-2 complex subunit alpha-1-like [KO:K11824]
125842048  AP-2 complex subunit mu-like [KO:K11826]
125875069  AP-2 complex subunit mu isoform X1 [KO:K11826]
125856498  AP-2 complex subunit sigma [KO:K11827]
125852941  clathrin interactor EPSIN 2 [KO:K12471]
125841157  clathrin interactor EPSIN 1-like [KO:K12471]
125871505  uncharacterized protein LOC125871505 [KO:K12471]
125871516  uncharacterized protein LOC125871516 [KO:K12471]
125844829  clathrin interactor EPSIN 1-like [KO:K12471]
125845053  uncharacterized protein LOC125845053 [KO:K12471]
125861214  clathrin interactor EPSIN 2-like [KO:K12471]
125849306  uncharacterized protein LOC125849306 [KO:K12472]
125854362  uncharacterized protein LOC125854362 isoform X1 [KO:K12472]
125846476  uncharacterized protein LOC125846476 [KO:K12472]
125848109  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
125849317  LOW QUALITY PROTEIN: protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
125867471  senescence/dehydration-associated protein At4g35985, chloroplastic-like [KO:K19366]
125858298  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
125857871  protein PAF1 homolog [KO:K23612]
125847719  actin-related protein 2 [KO:K17260]
125866743  actin-related protein 3 [KO:K18584]
125854909  actin-related protein 3-like [KO:K18584]
125868832  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
125851270  actin-related protein 2/3 complex subunit 2B isoform X1 [KO:K05758]
125844112  actin-related protein 2/3 complex subunit 2A [KO:K05758]
125875931  actin-related protein 2/3 complex subunit 3 [KO:K05756]
125863143  actin-related protein 2/3 complex subunit 4 [KO:K05755]
125849139  actin-related protein 2/3 complex subunit 5A [KO:K05754]
125876540  heat shock 70 kDa protein-like [KO:K03283]
125852021  heat shock cognate 70 kDa protein 2 [KO:K03283]
125853713  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
125854830  heat shock cognate 70 kDa protein 2-like [KO:K03283]
125871363  heat shock cognate 70 kDa protein 2-like [KO:K03283]
125872149  heat shock cognate 70 kDa protein 1 [KO:K03283]
125843652  heat shock cognate 70 kDa protein isoform X1 [KO:K03283]
125859288  heat shock 70 kDa protein 5 [KO:K03283]
125844307  heat shock 70 kDa protein 6, chloroplastic-like [KO:K03283]
125845445  heat shock cognate 70 kDa protein 2-like [KO:K03283]
125862289  heat shock 70 kDa protein [KO:K03283]
125848207  F-actin-capping protein subunit alpha isoform X1 [KO:K10364]
125863408  probable F-actin-capping protein subunit beta [KO:K10365]
125851435  vacuolar protein sorting-associated protein 29-like [KO:K18467]
125857831  vacuolar protein sorting-associated protein 29 [KO:K18467]
125855398  vacuolar protein sorting-associated protein 26A [KO:K18466]
125862730  vacuolar protein sorting-associated protein 35B-like isoform X1 [KO:K18468]
125858541  vacuolar protein sorting-associated protein 35A-like [KO:K18468]
125846660  vacuolar protein sorting-associated protein 35A [KO:K18468]
125860122  AMSH-like ubiquitin thioesterase 1 [KO:K11866] [EC:3.4.19.12]
125844803  AMSH-like ubiquitin thioesterase 3 isoform X1 [KO:K11866] [EC:3.4.19.12]
125855173  ras-related protein Rab7-like [KO:K07897]
125856800  ras-related protein Rab7 [KO:K07897]
125870789  ras-related protein RABG3f [KO:K07897]
125860416  ras-related protein Rab7 [KO:K07897]
125866009  protein ELC-like [KO:K12183]
125871193  protein ELC-like [KO:K12183]
125871575  protein ELC-like [KO:K12183]
125865369  vacuolar protein sorting-associated protein 28 homolog 2-like [KO:K12184]
125860525  vacuolar protein sorting-associated protein 28 homolog 2-like [KO:K12184]
125846839  vacuolar protein sorting-associated protein 28 homolog 2 [KO:K12184]
125865722  vacuolar protein-sorting-associated protein 37 homolog 1 isoform X1 [KO:K12185]
125865953  vacuolar protein-sorting-associated protein 37 homolog 1-like [KO:K12185]
125864639  vacuolar protein sorting-associated protein 22 homolog 1 [KO:K12188]
125844178  vacuolar protein sorting-associated protein 36 [KO:K12190]
125878182  vacuolar protein sorting-associated protein 25 [KO:K12189]
125863145  vacuolar protein sorting-associated protein 20 homolog 2 [KO:K12195]
125868303  vacuolar protein sorting-associated protein 32 homolog 2 [KO:K12194]
125841173  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
125844834  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
125872037  vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193]
125845500  vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193]
125862979  vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191]
125848740  vacuolar protein sorting-associated protein 2 homolog 2 [KO:K12191]
125872869  vacuolar protein sorting-associated protein 2 homolog 3-like isoform X1 [KO:K12192]
125873989  vacuolar protein sorting-associated protein 2 homolog 3-like [KO:K12192]
125846731  vacuolar protein sorting-associated protein 2 homolog 3-like isoform X1 [KO:K12192]
125865871  uncharacterized protein LOC125865871 [KO:K15053]
125843855  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like [KO:K12196]
125844102  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 isoform X1 [KO:K12196]
125875652  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5 [KO:K12199]
125859337  ESCRT-related protein CHMP1A [KO:K12197]
125874193  ESCRT-related protein CHMP1A-like [KO:K12197]
125851622  vacuolar protein sorting-associated protein 60.1-like [KO:K12198]
125866866  vacuolar protein sorting-associated protein 60.2-like [KO:K12198]
125850405  vacuolar-sorting protein BRO1 [KO:K12200]
125857175  vacuolar-sorting protein BRO1-like [KO:K12200]
125843183  uncharacterized protein LOC125843183 [KO:K19367]
125871116  sorting nexin 1 [KO:K17917]
125848687  ras-related protein RHN1 [KO:K07889]
125845150  ras-related protein RABF1 [KO:K07889]
125862542  EH domain-containing protein 1-like isoform X1 [KO:K12483]
125876838  EH domain-containing protein 1-like [KO:K12483]
125865126  EH domain-containing protein 1-like isoform X1 [KO:K12483]
125844143  EH domain-containing protein 1-like [KO:K12483]
125853130  vacuolar protein sorting-associated protein 45 homolog [KO:K12479]
125875245  ras-related protein RABE1c-like [KO:K07901]
125865682  ras-related protein RABE1c-like [KO:K07901]
125854637  ras-related protein RABE1c-like [KO:K07901]
125871233  ras-related protein RABE1a [KO:K07901]
125844980  ras-related protein RABE1c [KO:K07901]
125875735  ras-related protein YPT3 [KO:K07904]
125875859  ras-related protein RABA1f [KO:K07904]
125864260  ras-related protein RABA4d-like [KO:K07904]
125848863  ras-related protein RABA1d [KO:K07904]
125864910  ras-related protein RABA2a-like [KO:K07904]
125865005  ras-related protein RABA4d-like isoform X1 [KO:K07904]
125866367  ras-related protein RABA4d-like [KO:K07904]
125852928  ras-related protein RABA5e-like [KO:K07904]
125853315  ras-related protein RABA3 [KO:K07904]
125853716  ras-related protein RABA4d-like [KO:K07904]
125867542  ras-related protein RABA2b-like [KO:K07904]
125868003  ras-related protein RABA5a-like [KO:K07904]
125869327  ras-related protein RABA1f [KO:K07904]
125856934  ras-related protein Rab11D [KO:K07904]
125857601  ras-related protein RABA4d-like [KO:K07904]
125858074  ras-related protein RABA1f-like [KO:K07904]
125858392  ras-related protein RABA4d-like [KO:K07904]
125843703  ras-related protein RGP1-like [KO:K07904]
125859471  ras-related protein RABA2b-like [KO:K07904]
125872607  ras-related protein Rab11A [KO:K07904]
125872757  ras-related protein Rab2BV [KO:K07904]
125844409  ras-related protein RABA2a [KO:K07904]
125860107  ras-related protein RABA4d-like [KO:K07904]
125844694  ras-related protein RABA5a [KO:K07904]
125845216  ras-related protein Rab11D-like [KO:K07904]
125860959  ras-related protein RABA4d-like [KO:K07904]
125860960  ras-related protein RABA4d-like [KO:K07904]
125841335  kinesin-like protein KIN-UB [KO:K10396]
125847965  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
125876133  ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
125865054  ADP-ribosylation factor GTPase-activating protein AGD5-like isoform X1 [KO:K12486]
125842630  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
125859431  probable ADP-ribosylation factor GTPase-activating protein AGD15 [KO:K12486]
125860500  ADP-ribosylation factor GTPase-activating protein AGD5-like isoform X1 [KO:K12486]
125867108  ADP-ribosylation factor GTPase-activating protein AGD3 [KO:K12489]
125854869  ADP-ribosylation factor GTPase-activating protein AGD2-like [KO:K12489]
125858500  ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489]
125861951  ADP-ribosylation factor GTPase-activating protein AGD3-like isoform X1 [KO:K12489]
125864963  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
125870264  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
125878381  probable ADP-ribosylation factor GTPase-activating protein AGD9 [KO:K12493]
125842011  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
125871606  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
125845561  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
125866559  ARF guanine-nucleotide exchange factor GNOM [KO:K18443]
125854315  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
125859039  ARF guanine-nucleotide exchange factor GNL2 [KO:K18443]
125846411  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
125847055  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
125863256  ADP-ribosylation factor-like isoform X1 [KO:K07937]
125849201  ADP-ribosylation factor 2-B-like [KO:K07937]
125867141  ADP-ribosylation factor 1 [KO:K07937]
125867153  ADP-ribosylation factor 1 isoform X1 [KO:K07937]
125867967  ADP-ribosylation factor 2 isoform X1 [KO:K07937]
125868830  ADP-ribosylation factor 2-like [KO:K07937]
125857077  ADP-ribosylation factor 2-like [KO:K07937]
125860719  uncharacterized protein LOC125860719 [KO:K07937]
125874391  uncharacterized protein LOC125874391 [KO:K07937]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
sstn04070  Phosphatidylinositol signaling system
sstn04130  SNARE interactions in vesicular transport
KO pathway
ko04144   
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