KEGG   PATHWAY: sund04137
Entry
sund04137                   Pathway                                
Name
Mitophagy - animal - Sceloporus undulatus (fence lizard)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
sund04137  Mitophagy - animal
sund04137

Other DBs
GO: 0000422
Organism
Sceloporus undulatus (fence lizard) [GN:sund]
Gene
121919937  AMBRA1; LOW QUALITY PROTEIN: activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
121936230  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
121935342  TOMM7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
121916204  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
121915948  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
121922982  TOMM20L; TOMM20-like protein 1 [KO:K17770]
121919677  TOMM20; mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
121924990  TOMM70; mitochondrial import receptor subunit TOM70 [KO:K17768]
121936318  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
121932691  E3 ubiquitin-protein ligase MARCHF5-like [KO:K10660] [EC:2.3.2.27]
121926354  MARCHF5; E3 ubiquitin-protein ligase MARCHF5 [KO:K10660] [EC:2.3.2.27]
121936587  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
121914426  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
121921541  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
121914527  AMFR; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
121927148  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
121936413  MUL1; LOW QUALITY PROTEIN: mitochondrial ubiquitin ligase activator of NFKB 1 [KO:K15688] [EC:2.3.2.27]
121922316  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
121914505  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
121934160  ARIH1; E3 ubiquitin-protein ligase ARIH1 isoform X1 [KO:K11968] [EC:2.3.2.31]
121925598  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
121936124  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
121923316  RHOT1; mitochondrial Rho GTPase 1 isoform X1 [KO:K07870] [EC:3.6.5.-]
121914638  RHOT2; LOW QUALITY PROTEIN: mitochondrial Rho GTPase 2 [KO:K07871] [EC:3.6.5.-]
121916737  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
121929085  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
121934341  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
121932504  TAX1BP1; tax1-binding protein 1 [KO:K21347]
121921080  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
121933194  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
121931657  optineurin-like [KO:K19946]
121933636  NBR1; LOW QUALITY PROTEIN: next to BRCA1 gene 1 protein [KO:K17987]
121931127  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
121933122  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
121920610  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121914764  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121929874  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X1 [KO:K10435]
121920478  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
121914565  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121915303  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
121932861  BECN1; beclin-1 [KO:K08334]
121934289  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
121930772  USP15; ubiquitin carboxyl-terminal hydrolase 15 isoform X1 [KO:K21343] [EC:3.4.19.12]
121916719  USP30; ubiquitin carboxyl-terminal hydrolase 30 isoform X1 [KO:K11851] [EC:3.4.19.12]
121929893  BCL2L1; bcl-2-like protein 1 [KO:K04570]
121916421  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
121928590  CSNK2A1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
121928611  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
121914880  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
121923574  CSNK2B; LOW QUALITY PROTEIN: casein kinase II subunit beta [KO:K03115]
121914389  LOW QUALITY PROTEIN: casein kinase II subunit beta-like [KO:K03115]
121928245  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121916467  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
121927067  FUNDC1; FUN14 domain-containing protein 1 [KO:K17986]
121925201  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
121934719  BNIP3L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
121930758  BCL2L13; bcl-2-like protein 13 isoform X1 [KO:K15485]
121934869  peptidyl-prolyl cis-trans isomerase FKBP8-like isoform X1 [KO:K09574] [EC:5.2.1.8]
121936192  FKBP8; peptidyl-prolyl cis-trans isomerase FKBP8 [KO:K09574] [EC:5.2.1.8]
121931187  SAMM50; sorting and assembly machinery component 50 homolog [KO:K07277]
121920955  PHB2; prohibitin-2 isoform X1 [KO:K17081]
121934502  NLRX1; NLR family member X1 [KO:K12653]
121916277  MTX1; metaxin-1 [KO:K17776]
121915709  MTX2; metaxin-2 isoform X1 [KO:K17776]
121922257  MTX3; metaxin-3 isoform X1 [KO:K17776]
121934276  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
121928239  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
121918233  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
121931934  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121923830  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121931541  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121928905  JUN; transcription factor AP-1 [KO:K04448]
121915610  RELA; transcription factor p65 isoform X1 [KO:K04735]
121926328  HRAS; GTPase HRas [KO:K02833]
121935008  GTPase HRas [KO:K07827]
121931822  KRAS; GTPase KRas isoform X1 [KO:K07827]
121929449  NRAS; GTPase NRas [KO:K07828]
121928589  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
121916458  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
121935514  RRAS; ras-related protein R-Ras [KO:K07830]
121928742  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
121927190  HIF1A; LOW QUALITY PROTEIN: hypoxia-inducible factor 1-alpha [KO:K08268]
121921686  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
121932555  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
121919330  FOXO3; forkhead box protein O3 [KO:K09408]
121919543  CITED2; cbp/p300-interacting transactivator 2 [KO:K21361]
121916064  cbp/p300-interacting transactivator 3-like isoform X1 [KO:K21361]
121922378  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
121928586  TFEB; transcription factor EB [KO:K15590]
121920783  TFE3; LOW QUALITY PROTEIN: transcription factor E3 [KO:K09105]
121916950  RABGEF1; rab5 GDP/GTP exchange factor isoform X1 [KO:K20131]
121934513  RAB5A; ras-related protein Rab-5A [KO:K07887]
121921421  RAB5B; ras-related protein Rab-5B [KO:K07888]
121934553  RAB5C; ras-related protein Rab-5C [KO:K07889]
121922344  MON1B; vacuolar fusion protein MON1 homolog B [KO:K20195]
121921500  MON1A; vacuolar fusion protein MON1 homolog A isoform X1 [KO:K20195]
121914723  CCZ1; LOW QUALITY PROTEIN: vacuolar fusion protein CCZ1 homolog [KO:K27045]
121922071  RAB7A; ras-related protein Rab-7a [KO:K07897]
121924308  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
121929461  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
121930883  TBC1D15; TBC1 domain family member 15 [KO:K20168]
121934252  TBC1D17; TBC1 domain family member 17 isoform X1 [KO:K19945]
121933396  FIS1; mitochondrial fission 1 protein [KO:K17969]
121927775  ATG9A; autophagy-related protein 9A isoform X1 [KO:K17907]
121934955  ATG9B; LOW QUALITY PROTEIN: autophagy-related protein 9B [KO:K17907]
121925137  OPA1; dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
121922493  transitional endoplasmic reticulum ATPase [KO:K13525]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
sund04140  Autophagy - animal
sund04210  Apoptosis
KO pathway
ko04137   
LinkDB

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