KEGG   PATHWAY: svg00600
Entry
svg00600                    Pathway                                
Name
Sphingolipid metabolism - Sturnus vulgaris (common starling)
Class
Metabolism; Lipid metabolism
Pathway map
svg00600  Sphingolipid metabolism
svg00600

Module
svg_M00066  Lactosylceramide biosynthesis [PATH:svg00600]
svg_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:svg00600]
svg_M00094  Ceramide biosynthesis [PATH:svg00600]
svg_M00099  Sphingosine biosynthesis [PATH:svg00600]
svg_M00100  Sphingosine degradation [PATH:svg00600]
Other DBs
GO: 0006665
Organism
Sturnus vulgaris (common starling) [GN:svg]
Gene
106848927  SPTLC1; serine palmitoyltransferase 1 isoform X1 [KO:K00654] [EC:2.3.1.50]
106865160  SPTLC3; LOW QUALITY PROTEIN: serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
106849301  SPTLC2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
106850824  KDSR; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
106859702  CERS1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
106857974  CERS4; ceramide synthase 4 [KO:K24621] [EC:2.3.1.297]
106862352  CERS2; ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
106852186  CERS3; LOW QUALITY PROTEIN: ceramide synthase 3 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
106863124  CERS5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
106862102  CERS6; ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
106851496  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
106856689  ASAH2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
106849904  ACER2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
106857101  ACER1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
106859830  ACER3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
106853899  DEGS1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
106850558  DEGS2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
106854395  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
106856716  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
106861733  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
106851041  SMPD2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
106855854  SMPD3; sphingomyelin phosphodiesterase 3 isoform X1 [KO:K12352] [EC:3.1.4.12]
106864941  SMPD4; sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
106859887  ENPP7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
106848800  CERK; ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
106859613  PLPP1; lipid phosphate phosphohydrolase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
106849751  PLPP3; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
106857143  PLPP2; lipid phosphate phosphohydrolase 2 [KO:K01080] [EC:3.1.3.4]
106850277  SGPP1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
106855136  SGPP2; sphingosine-1-phosphate phosphatase 2 isoform X1 [KO:K04717] [EC:3.1.3.-]
106860989  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
106857313  SGPL1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
106861024  UGCG; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
106861101  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
106861127  glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
106861128  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
106852685  GBA2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
106851951  B4GALT6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
106853032  B4GALT5; LOW QUALITY PROTEIN: beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
106854473  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
106855308  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K04628] [EC:2.4.1.47]
106860196  UGT8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1 [KO:K04628] [EC:2.4.1.47]
106849317  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
106864982  GAL3ST1; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
106864369  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
106849712  NEU4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
106855116  NEU2; sialidase-2 isoform X1 [KO:K12357] [EC:3.2.1.18]
106860708  NEU3; sialidase-3 [KO:K12357] [EC:3.2.1.18]
106853734  GLA; alpha-galactosidase A isoform X1 [KO:K01189] [EC:3.2.1.22]
106862641  B4GALNT1; beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
106859085  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
106861054  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
106859601  GM2A; ganglioside GM2 activator [KO:K12383]
106857308  proactivator polypeptide isoform X1 [KO:K12382]
106857310  LOW QUALITY PROTEIN: proactivator polypeptide-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
svg00260  Glycine, serine and threonine metabolism
svg00601  Glycosphingolipid biosynthesis - lacto and neolacto series
svg00603  Glycosphingolipid biosynthesis - globo and isoglobo series
svg00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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