KEGG   PATHWAY: tfs04514
Entry
tfs04514                    Pathway                                
Name
Cell adhesion molecules - Takifugu flavidus (sansaifugu)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
tfs04514  Cell adhesion molecules
tfs04514

Other DBs
GO: 0050839
Organism
Takifugu flavidus (sansaifugu) [GN:tfs]
Gene
130533961  SLAM family member 9-like [KO:K06492]
130536071  uncharacterized protein LOC130536071 [KO:K06449]
130523464  T-cell surface antigen CD2-like [KO:K06449]
130533962  vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
130535621  igsf11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
130537364  zgc:165604; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
130522188  si:dkey-1h24.6; T-cell-specific surface glycoprotein CD28 [KO:K06470]
130535567  uncharacterized protein LOC130535567 isoform X1 [KO:K05413]
130528943  ICOS ligand-like [KO:K06710]
130520572  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
130520573  LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
130539820  M1-specific T cell receptor beta chain-like [KO:K10785]
130532967  cd4-1; CD4-1 molecule isoform X1 [KO:K06454]
130537989  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
130537990  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
130537991  major histocompatibility complex class I-related gene protein-like [KO:K06751]
130518252  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
130518253  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
130518452  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
130518549  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
130518550  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
130518715  major histocompatibility complex class I-related gene protein-like [KO:K06751]
130518716  major histocompatibility complex class I-related gene protein-like [KO:K06751]
130524209  cd8a; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
130524208  cd8b; uncharacterized protein cd8b [KO:K06459]
130513731  cd276; CD276 antigen [KO:K06746]
130534111  vtcn1; V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
130530672  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
130533012  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
130535036  CD166 antigen homolog A-like isoform X1 [KO:K06547]
130537459  alcama; CD166 antigen homolog A isoform X1 [KO:K06547]
130518186  T-cell differentiation antigen CD6-like isoform X1 [KO:K06456]
130514187  cd226; CD226 antigen isoform X1 [KO:K06567]
130532962  si:ch73-22o12.1; poliovirus receptor homolog isoform X1 [KO:K06531]
130527282  zmp:0000001082; integrin alpha-D isoform X1 [KO:K05718]
130528034  itgb2; integrin beta-2 isoform X1 [KO:K06464]
130526879  uncharacterized protein LOC130526879 [KO:K06467]
130533145  si:dkey-33i11.1; sialoadhesin isoform X1 [KO:K06467]
130527423  B-cell receptor CD22-like [KO:K06467]
130519649  B-cell receptor CD22-like isoform X1 [KO:K06467]
130520604  B-cell receptor CD22-like [KO:K06467]
130521140  uncharacterized protein LOC130521140 [KO:K06467]
130532134  B-cell receptor CD22-like isoform X1 [KO:K06467]
130532141  B-cell receptor CD22-like isoform X1 [KO:K06467]
130532275  si:dkey-24p1.1; B-cell receptor CD22 isoform X1 [KO:K06467]
130532429  B-cell receptor CD22-like [KO:K06467]
130526832  pregnancy-specific beta-1-glycoprotein 8-like isoform X1 [KO:K06467]
130526837  B-cell receptor CD22-like isoform X1 [KO:K06467]
130529019  ptprc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
130535035  nectin3a; nectin-3-like protein [KO:K06592]
130537634  nectin3b; nectin-3-like protein isoform X1 [KO:K06592]
130527122  claudin-9-like isoform X1 [KO:K06087]
130513246  cldn23l; claudin-23 [KO:K06087]
130540340  cldn11a; claudin-11a [KO:K06087]
130540347  claudin-20 [KO:K06087]
130534463  claudin-19-like isoform X1 [KO:K06087]
130534638  cldn8.2; claudin-8 [KO:K06087]
130534643  claudin-17-like [KO:K06087]
130534647  cldn8.1; claudin-8 [KO:K06087]
130534649  claudin-4-like [KO:K06087]
130534652  claudin-4-like isoform X1 [KO:K06087]
130534654  claudin-3-like [KO:K06087]
130534655  cldnj; claudin j [KO:K06087]
130514077  cldn11b; claudin-11b [KO:K06087]
130534657  claudin-4-like [KO:K06087]
130534661  claudin-3-like [KO:K06087]
130534662  claudin-3-like [KO:K06087]
130522278  putative claudin-24 [KO:K06087]
130522533  cldn7a; claudin-7-A [KO:K06087]
130528807  cldn34a; claudin-34 [KO:K06087]
130528808  putative claudin-24 [KO:K06087]
130522659  claudin-10-like [KO:K06087]
130522786  cldn10e; claudin-10 isoform X1 [KO:K06087]
130522787  cldn10d; claudin-10 [KO:K06087]
130529524  claudin-10-like [KO:K06087]
130515305  cldni; claudin i [KO:K06087]
130523300  cldn15a; claudin-15a [KO:K06087]
130529528  claudin-10 [KO:K06087]
130529534  cldn10b; claudin-10 isoform X1 [KO:K06087]
130516047  claudin-20-like [KO:K06087]
130516838  cldn23.1; claudin 23a [KO:K06087]
130524422  cldn19; claudin-19 isoform X1 [KO:K06087]
130537049  cldn2; claudin-2 [KO:K06087]
130537281  claudin-7-A-like [KO:K06087]
130537617  claudin-4-like isoform X1 [KO:K06087]
130537621  claudin-4-like [KO:K06087]
130537622  claudin-4-like [KO:K06087]
130537623  claudin-3-like [KO:K06087]
130537624  cldnb; claudin b [KO:K06087]
130537625  claudin-4 [KO:K06087]
130537626  cldn29; claudin 29 [KO:K06087]
130537628  claudin-like protein ZF-A89 [KO:K06087]
130517245  cldn5b; claudin-5b [KO:K06087]
130537885  claudin-15-like isoform X1 [KO:K06087]
130517805  cldn35; claudin-4 [KO:K06087]
130532050  cldn12; claudin-12 [KO:K06087]
130538505  cldn18; claudin-18 isoform X1 [KO:K06087]
130526054  cldn26; putative claudin-24 [KO:K06087]
130526236  cldn5a; claudin 5a [KO:K06087]
130539172  cldn15la; claudin 15-like a [KO:K06087]
130539219  cldn1; claudin-1 [KO:K06087]
130529319  si:ch73-61d6.3; occludin [KO:K06088]
130537066  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
130522361  jam2a; junctional adhesion molecule 2A isoform X1 [KO:K06735]
130536194  jam2b; junctional adhesion molecule 2b [KO:K06735]
130534802  jam3a; junctional adhesion molecule 3B [KO:K06785]
130538091  junctional adhesion molecule 3B-like [KO:K06785]
130534800  esamb; endothelial cell-selective adhesion molecule isoform X1 [KO:K06787]
130537432  esama; endothelial cell adhesion molecule a [KO:K06787]
130534329  cdh5; cadherin-5 [KO:K06533]
130527294  pecam1b; LOW QUALITY PROTEIN: platelet endothelial cell adhesion molecule [KO:K06471]
130514833  pecam1a; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
130522693  cd99; CD99 molecule isoform X1 [KO:K06520]
130522953  cd99l2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
130522418  integrin alpha-X-like isoform X1 [KO:K06461]
130528996  selp; LOW QUALITY PROTEIN: P-selectin [KO:K06496]
130528782  itga4; integrin alpha-4 [KO:K06483]
130514064  integrin beta-1-like isoform X1 [KO:K05719]
130539555  integrin beta-1-like [KO:K05719]
130533519  itga9; integrin alpha-9 [KO:K06585]
130528438  vcam1b; vascular cell adhesion protein 1b [KO:K06527]
130528995  L-selectin-like isoform X1 [KO:K06495]
130530199  cd34; uncharacterized protein cd34 isoform X1 [KO:K06474]
130524651  si:ch211-286o17.1; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
130521611  Golgi apparatus protein 1-like isoform X1 [KO:K06816]
130536225  glg1a; Golgi apparatus protein 1 [KO:K06816]
130528994  E-selectin-like [KO:K06494]
130534575  nectin1b; nectin cell adhesion molecule 1b isoform X1 [KO:K06081]
130534985  nectin-1-like isoform X1 [KO:K06081]
130535058  nectin-1-like isoform X1 [KO:K06081]
130535128  nectin-1-like isoform X1 [KO:K06081]
130535154  nectin-1-like isoform X1 [KO:K06081]
130537478  nectin1a; nectin cell adhesion molecule 1a isoform X1 [KO:K06081]
130528248  cadherin-2-like [KO:K06736]
130538635  cdh2; cadherin-2 [KO:K06736]
130535263  ncam1b; neural cell adhesion molecule 1b isoform X1 [KO:K06491]
130522796  neural cell adhesion molecule 2-like isoform X1 [KO:K06491]
130537367  ncam1a; neural cell adhesion molecule 1a isoform X1 [KO:K06491]
130532863  ncam3; neural cell adhesion molecule 1 [KO:K06491]
130529419  l1cama; neural cell adhesion molecule L1.2 isoform X1 [KO:K06550]
130529616  LOW QUALITY PROTEIN: neural cell adhesion molecule L1-like [KO:K06550]
130530739  LOW QUALITY PROTEIN: neural cell adhesion molecule L1-like [KO:K06550]
130534994  cadm1b; cell adhesion molecule 1b isoform X1 [KO:K06781]
130537058  cadm1a; cell adhesion molecule 1a isoform X1 [KO:K06781]
130528858  negr1; neuronal growth regulator 1 isoform X1 [KO:K06775]
130539520  netrin-G1-like isoform X1 [KO:K07522]
130513447  ntng1a; netrin-G1 isoform X1 [KO:K07522]
130521509  leucine-rich repeat-containing protein 4C-like [KO:K07523]
130536280  lrrc4ca; leucine rich repeat containing 4C, genome duplicate a [KO:K07523]
130525993  netrin-G2-like [KO:K16359]
130518998  lrrc4.1; leucine-rich repeat-containing protein 4 [KO:K16351]
130536497  lrrc4.2; leucine-rich repeat-containing protein 4.2 [KO:K16351]
130528143  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
130538315  receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
130528647  lrrc4bb; leucine-rich repeat-containing protein 4B [KO:K16360]
130514955  lrrc4ba; leucine-rich repeat-containing protein 4B [KO:K16360]
130518180  sdc2; syndecan-2 [KO:K16336]
130532274  syndecan-2-like isoform X1 [KO:K16336]
130518723  sdc3; syndecan-3 [KO:K16337]
130524980  sdc4; syndecan-4 isoform X1 [KO:K16338]
130527191  LOW QUALITY PROTEIN: integrin alpha-V-like [KO:K06487]
130518243  itgb8; integrin beta-8 isoform X1 [KO:K06591]
130533227  itga8; integrin alpha-8 [KO:K06584]
130533371  neurexin-1a-like isoform X1 [KO:K07377]
130539689  nrxn3a; neurexin 3a isoform X1 [KO:K07377]
130513024  nrxn1a; LOW QUALITY PROTEIN: neurexin 1a [KO:K07377]
130522288  nrxn2b; neurexin 2b isoform X1 [KO:K07377]
130515936  nrxn3b; neurexin 3b isoform X1 [KO:K07377]
130528249  nlgn1; neuroligin-1 isoform X1 [KO:K07378]
130522103  nlgn4xa; neuroligin 4 X-linked a isoform X1 [KO:K07378]
130522576  nlgn2a; neuroligin-2a isoform X1 [KO:K07378]
130530073  neuroligin-4, X-linked-like [KO:K07378]
130537265  nlgn2b; neuroligin-2b isoform X1 [KO:K07378]
130531108  nlgn3a; neuroligin-3a isoform X1 [KO:K07378]
130537655  nlgn3b; neuroligin-3b isoform X1 [KO:K07378]
130529362  ptprsa; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
130539087  receptor-type tyrosine-protein phosphatase S-like isoform X1 [KO:K06778] [EC:3.1.3.48]
130522876  SLIT and NTRK-like protein 1 [KO:K25832]
130531836  slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]
130531837  slitrk4; SLIT and NTRK-like protein 4 [KO:K25835]
130522434  SLIT and NTRK-like protein 5 [KO:K25836]
130532041  slitrk5b; SLIT and NTRK-like protein 5 [KO:K25836]
130522863  slitrk6; SLIT and NTRK-like protein 6 [KO:K25837]
130527272  ptprdb; protein tyrosine phosphatase receptor type Db isoform X1 [KO:K06777] [EC:3.1.3.48]
130522885  receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
130540393  LOW QUALITY PROTEIN: SLIT and NTRK-like protein 3 [KO:K25834]
130535465  slitrk3a; SLIT and NTRK-like protein 3 [KO:K25834]
130519398  nrcama; neuronal cell adhesion molecule a isoform X1 [KO:K06756]
130535812  neuronal cell adhesion molecule-like isoform X1 [KO:K06756]
130519400  cntn1b; contactin 1b [KO:K06759]
130536780  cntn1a; contactin-1a [KO:K06759]
130513813  receptor-type tyrosine-protein phosphatase mu-like isoform X1 [KO:K05693] [EC:3.1.3.48]
130538732  receptor-type tyrosine-protein phosphatase mu-like isoform X1 [KO:K05693] [EC:3.1.3.48]
130524713  cntn2; contactin-2 isoform X1 [KO:K06760]
130529651  nfascb; neurofascin [KO:K06757]
130524706  nfasca; neurofascin homolog (chicken) a isoform X1 [KO:K06757]
130514965  cntnap1; contactin-associated protein 1 [KO:K07379]
130513855  cntnap2a; contactin-associated protein-like 2a [KO:K07380]
130538569  cntnap2b; contactin-associated protein-like 2b [KO:K07380]
130538632  mpz; myelin protein P0 isoform X1 [KO:K06770]
130532277  myelin-associated glycoprotein-like isoform X1 [KO:K06771]
130532742  myelin-associated glycoprotein-like [KO:K06771]
130533542  cdh31; B-cadherin isoform X1 [KO:K05689]
130536803  cadherin-1-like [KO:K05689]
130524989  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
130531883  integrin alpha-6-like [KO:K06485]
130538421  integrin alpha-6-like isoform X1 [KO:K06485]
130529841  cadherin-4-like [KO:K06797]
130524890  cdh4; cadherin-4 isoform X1 [KO:K06797]
130521824  cdh15; cadherin-15 [KO:K06809]
130521625  neo1a; neogenin 1a isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
tfs04520  Adherens junction
tfs04530  Tight junction
KO pathway
ko04514   
LinkDB

DBGET integrated database retrieval system