Entry
Name
mRNA surveillance pathway - Tarenaya hassleriana (spider flower)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Tarenaya hassleriana (spider flower) [GN:
thj ]
Gene
104806760 regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328 ]
104815973 regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328 ]
104807709 apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875 ]
104824862 apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875 ]
104813616 serine/arginine-rich splicing factor SR45-like isoform X1 [KO:K14325 ]
104800686 serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171 ]
104813448 cleavage and polyadenylation specificity factor subunit 6-like [KO:K14398 ]
104824017 cleavage and polyadenylation specificity factor subunit CG7185-like [KO:K14398 ]
104812944 polyadenylation and cleavage factor homolog 4 isoform X1 [KO:K14400 ]
104825074 cleavage and polyadenylation specificity factor subunit 1 [KO:K14401 ]
104821393 cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402 ]
104819173 cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403 ] [EC:3.1.27.-]
104798605 30-kDa cleavage and polyadenylation specificity factor 30 [KO:K14404 ]
104818519 LOW QUALITY PROTEIN: cleavage stimulation factor subunit 50 [KO:K14406 ]
104817697 heterogeneous nuclear ribonucleoprotein 1-like isoform X1 [KO:K14411 ]
104799994 eukaryotic peptide chain release factor subunit 1-1-like [KO:K03265 ]
104807998 eukaryotic peptide chain release factor subunit 1-1-like [KO:K03265 ]
104813913 eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267 ]
104812160 eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like [KO:K03267 ]
104805249 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
104821949 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
104824034 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456 ]
104805916 serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354 ]
104798709 serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354 ]
104812210 serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
104813945 serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
104817931 serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354 ]
104801146 serine/threonine protein phosphatase 2A regulatory subunit B''alpha isoform X1 [KO:K11583 ]
104805784 probable serine/threonine protein phosphatase 2A regulatory subunit B''delta isoform X1 [KO:K11583 ]
104801728 serine/threonine protein phosphatase 2A regulatory subunit B''beta-like [KO:K11583 ]
104802847 serine/threonine protein phosphatase 2A regulatory subunit B''beta [KO:K11583 ]
104821241 probable serine/threonine protein phosphatase 2A regulatory subunit B''delta [KO:K11583 ]
104818847 probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583 ]
104807730 serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584 ]
104809975 serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform isoform X1 [KO:K11584 ]
104809018 serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform-like [KO:K11584 ]
104826920 serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584 ]
104812226 serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584 ]
104816360 serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584 ]
104820217 serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform-like [KO:K11584 ]
104815041 serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform [KO:K11584 ]
104821755 serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform-like [KO:K11584 ]
104824020 serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform [KO:K11584 ]
104824023 serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform [KO:K11584 ]
104825528 serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584 ]
Reference
Authors
Maquat LE
Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
Journal
Reference
Authors
Amrani N, Sachs MS, Jacobson A
Title
Early nonsense: mRNA decay solves a translational problem.
Journal
Reference
Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
Title
P bodies: at the crossroads of post-transcriptional pathways.
Journal
Reference
Authors
Mandel CR, Bai Y, Tong L
Title
Protein factors in pre-mRNA 3'-end processing.
Journal
Reference
Authors
Clement SL, Lykke-Andersen J
Title
No mercy for messages that mess with the ribosome.
Journal
Related pathway
KO pathway
LinkDB
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