KEGG   PATHWAY: umr00830
Entry
umr00830                    Pathway                                
Name
Retinol metabolism - Ursus maritimus (polar bear)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
umr00830  Retinol metabolism
umr00830

Other DBs
GO: 0006776
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656298  UGT2B4; LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
103656322  [KO:K00699] [EC:2.4.1.17]
103656323  HSD17B6; 17-beta-hydroxysteroid dehydrogenase type 6 isoform X1 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
103656324  [KO:K00699] [EC:2.4.1.17]
103656387  RDH16; retinol dehydrogenase 16 isoform X1 [KO:K11154] [EC:1.1.1.-]
103656696  [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
103658037  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
103658573  [KO:K17951] [EC:1.14.19.53]
103659536  DHRS9; dehydrogenase/reductase SDR family member 9 [KO:K11149] [EC:1.1.-.-]
103659697  [KO:K07413] [EC:1.14.14.1]
103659730  [KO:K00157] [EC:1.2.3.1]
103659731  [KO:K00157] [EC:1.2.3.1]
103659946  [KO:K00157] [EC:1.2.3.1]
103660039  ALDH1A3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
103661053  [KO:K07411] [EC:1.14.14.1]
103661107  [KO:K07411] [EC:1.14.14.1]
103662084  BCO1; beta,beta-carotene 15,15'-dioxygenase isoform X1 [KO:K00515] [EC:1.13.11.63]
103662655  [KO:K00699] [EC:2.4.1.17]
103663024  RPE65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
103663346  [KO:K07249] [EC:1.2.1.36]
103663347  [KO:K07249] [EC:1.2.1.36]
103666318  PNPLA4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
103666638  DHRS3; short-chain dehydrogenase/reductase 3 isoform X1 [KO:K11146] [EC:1.1.1.300]
103668081  [KO:K07437] [EC:1.14.14.-]
103669994  [KO:K07424] [EC:1.14.14.1]
103669998  [KO:K07424] [EC:1.14.14.1]
103669999  [KO:K07424] [EC:1.14.14.1]
103670060  [KO:K07423] [EC:1.14.14.-]
103670742  [KO:K07425] [EC:1.14.14.80]
103670756  [KO:K07413] [EC:1.14.14.1]
103671449  RETSAT; all-trans-retinol 13,14-reductase isoform X2 [KO:K09516] [EC:1.3.99.23]
103671821  [KO:K12664] [EC:1.14.14.-]
103671847  RDH12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
103671858  RDH11; retinol dehydrogenase 11 [KO:K11152] [EC:1.1.1.300]
103676790  ALDH1A2; retinal dehydrogenase 2 isoform X1 [KO:K07249] [EC:1.2.1.36]
103677389  [KO:K07412] [EC:1.14.14.1]
103677390  [KO:K07412] [EC:1.14.14.1]
103677397  [KO:K07420] [EC:1.14.14.1]
103677445  SDR16C5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
103677920  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
103677922  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
103677923  [KO:K13952] [EC:1.1.1.1]
103677925  [KO:K13951] [EC:1.1.1.1]
103678699  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
103678991  [KO:K07409] [EC:1.14.14.1]
103678992  [KO:K07408] [EC:1.14.14.1]
103679183  [KO:K00699] [EC:2.4.1.17]
103679316  [KO:K11147] [EC:1.1.-.-]
103680271  RDH13; retinol dehydrogenase 13 isoform X1 [KO:K11161] [EC:1.1.1.300]
103680319  [KO:K07411] [EC:1.14.14.1]
103680449  [KO:K07411] [EC:1.14.14.1]
103681285  RDH10; retinol dehydrogenase 10 isoform X2 [KO:K11151] [EC:1.1.1.-]
103682388  RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
103682604  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
121101202  [KO:K12665] [EC:1.14.14.-]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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