KEGG   PATHWAY: umr00830
Entry
umr00830                    Pathway                                
Name
Retinol metabolism - Ursus maritimus (polar bear)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
umr00830  Retinol metabolism
umr00830

Other DBs
GO: 0006776
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103662084  BCO1; beta,beta-carotene 15,15'-dioxygenase isoform X1 [KO:K00515] [EC:1.13.11.63]
103677925  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
103677922  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
103677920  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
103677923  alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
103666638  DHRS3; short-chain dehydrogenase/reductase 3 isoform X1 [KO:K11146] [EC:1.1.1.300]
103679316  dehydrogenase/reductase SDR family member 4 isoform X1 [KO:K11147] [EC:1.1.-.-]
103659536  DHRS9; dehydrogenase/reductase SDR family member 9 [KO:K11149] [EC:1.1.-.-]
103678699  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
103681285  RDH10; retinol dehydrogenase 10 isoform X2 [KO:K11151] [EC:1.1.1.-]
103671858  RDH11; retinol dehydrogenase 11 [KO:K11152] [EC:1.1.1.300]
103671847  RDH12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
103680271  RDH13; retinol dehydrogenase 13 isoform X1 [KO:K11161] [EC:1.1.1.300]
103656387  RDH16; retinol dehydrogenase 16 isoform X1 [KO:K11154] [EC:1.1.1.-]
103677445  SDR16C5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
103656323  HSD17B6; 17-beta-hydroxysteroid dehydrogenase type 6 isoform X1 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
103658037  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
103656696  diacylglycerol O-acyltransferase 1 isoform X1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
103682604  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
103666318  PNPLA4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
103663024  RPE65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
103682388  RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
103659730  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
103659731  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
103659946  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
103676790  ALDH1A2; retinal dehydrogenase 2 isoform X1 [KO:K07249] [EC:1.2.1.36]
103663346  retinal dehydrogenase 1 [KO:K07249] [EC:1.2.1.36]
103663347  retinal dehydrogenase 1 [KO:K07249] [EC:1.2.1.36]
103660039  ALDH1A3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
103668081  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
103671821  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
121101202  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
103678992  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
103678991  cytochrome P450 1A2 isoform X3 [KO:K07409] [EC:1.14.14.1]
103661053  cytochrome P450 2A13 [KO:K07411] [EC:1.14.14.1]
103661107  cytochrome P450 2A13-like [KO:K07411] [EC:1.14.14.1]
103680319  cytochrome P450 2A13 [KO:K07411] [EC:1.14.14.1]
103680449  cytochrome P450 2A13-like [KO:K07411] [EC:1.14.14.1]
103677389  cytochrome P450 2B11 [KO:K07412] [EC:1.14.14.1]
103677390  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
103670756  cytochrome P450 2C21 [KO:K07413] [EC:1.14.14.1]
103659697  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
103677397  cytochrome P450 2S1 isoform X1 [KO:K07420] [EC:1.14.14.1]
103669998  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
103669994  cytochrome P450 3A12 [KO:K07424] [EC:1.14.14.1]
103669999  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
103670060  cytochrome P450 2W1 [KO:K07423] [EC:1.14.14.-]
103670742  cytochrome P450 4A6 [KO:K07425] [EC:1.14.14.80]
103662655  UDP-glucuronosyltransferase 1A1-like isoform X2 [KO:K00699] [EC:2.4.1.17]
103656322  UDP-glucuronosyltransferase 2A3 isoform X3 [KO:K00699] [EC:2.4.1.17]
103656324  UDP-glucuronosyltransferase 2A1-like isoform X2 [KO:K00699] [EC:2.4.1.17]
103679183  UDP-glucuronosyltransferase 2B31 isoform X1 [KO:K00699] [EC:2.4.1.17]
103656298  UGT2B4; LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
103671449  RETSAT; all-trans-retinol 13,14-reductase isoform X2 [KO:K09516] [EC:1.3.99.23]
103658573  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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