KEGG   PATHWAY: phas04810
Entry
phas04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Phyllostomus hastatus (greater spear-nosed bat)
Class
Cellular Processes; Cell motility
Pathway map
phas04810  Regulation of actin cytoskeleton
phas04810

Other DBs
GO: 0030036
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123804307  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
123804347  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
123804403  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
123804414  NRAS; GTPase NRas [KO:K07828]
123804734  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
123804736  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
123804746  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
123805088  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
123805100  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
123805160  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
123805534  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123805628  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123805863  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
123806040  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
123806258  MYH11; myosin-11 isoform X1 [KO:K10352]
123806439  MYL10; myosin regulatory light chain 10 [KO:K12756]
123806482  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
123806569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123806597  CRKL; crk-like protein isoform X1 [KO:K04438]
123806803  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123806820  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
123806865  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123807317  HRAS; GTPase HRas isoform X1 [KO:K02833]
123807354  INS; insulin isoform X1 [KO:K04526]
123807403  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
123807437  ACTB; actin, cytoplasmic 1 [KO:K05692]
123807471  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123807517  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123807646  FGF20; fibroblast growth factor 20 [KO:K04358]
123807983  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123808033  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123808069  FGF7; fibroblast growth factor 7 [KO:K04358]
123808110  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123808275  ITGA11; integrin alpha-11 [KO:K06587]
123808493  [KO:K05756]
123808510  [KO:K05735] [EC:2.7.11.1]
123808608  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123808622  BDKRB1; B1 bradykinin receptor [KO:K03915]
123808688  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
123808839  BDKRB2; B2 bradykinin receptor [KO:K03916]
123809230  MYH10; myosin-10 isoform X1 [KO:K10352]
123809269  PFN1; profilin-1 [KO:K05759]
123809434  ITGAE; integrin alpha-E [KO:K06524]
123809602  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
123809603  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
123809696  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
123809949  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
123810066  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
123810187  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
123810363  ACTR3; actin-related protein 3 [KO:K18584]
123810370  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
123810462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123810721  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123810728  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
123810790  FGF1; fibroblast growth factor 1 [KO:K18496]
123810960  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
123810976  FGF18; fibroblast growth factor 18 [KO:K04358]
123811026  PFN4; profilin-4 [KO:K05759]
123811120  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123811124  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123811385  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
123811430  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123811434  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
123811729  ACTR2; actin-related protein 2 [KO:K17260]
123811825  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
123811857  [KO:K05764]
123812020  SCIN; adseverin [KO:K05768]
123812406  KRAS; GTPase KRas isoform X1 [KO:K07827]
123812463  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
123812542  [KO:K05752]
123812639  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
123812759  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123812834  ITGA5; integrin alpha-5 [KO:K06484]
123812884  NCKAP1L; nck-associated protein 1-like [KO:K05750]
123813236  PFN3; profilin-3 [KO:K05759]
123813340  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
123813424  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
123813509  FGF23; fibroblast growth factor 23 [KO:K22428]
123813510  FGF6; fibroblast growth factor 6 [KO:K04358]
123813640  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123813667  FGF2; fibroblast growth factor 2 [KO:K18497]
123813708  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
123813920  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
123814061  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
123814141  PDGFC; platelet-derived growth factor C [KO:K05450]
123814146  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
123814292  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
123814364  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123814593  BRK1; protein BRICK1 [KO:K05752]
123814829  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
123814893  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
123815319  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
123815356  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
123815386  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
123815579  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123815667  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123815938  MYL5; myosin light chain 5 [KO:K12753]
123816090  MYH9; myosin-9 isoform X1 [KO:K10352]
123816209  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123816243  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
123816445  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123816761  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
123816849  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
123816905  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123816998  ITGA3; integrin alpha-3 [KO:K06482]
123817058  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
123817129  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
123817155  ITGA2B; integrin alpha-IIb [KO:K06476]
123817163  ITGB3; integrin beta-3 [KO:K06493]
123817221  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
123817321  CRK; adapter molecule crk isoform X1 [KO:K04438]
123817374  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123817522  [KO:K05764]
123817745  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
123817999  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
123818031  RDX; radixin isoform X1 [KO:K05762]
123818046  [KO:K02085]
123818075  [KO:K02085]
123818143  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
123818169  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
123818238  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
123818504  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
123818640  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
123818796  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
123818831  RGCC; regulator of cell cycle RGCC [KO:K26108]
123818893  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
123819077  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
123819523  ITGA2; integrin alpha-2 [KO:K06481]
123819526  ITGA1; integrin alpha-1 [KO:K06480]
123819554  FGF10; fibroblast growth factor 10 [KO:K04358]
123819697  [KO:K05764]
123819722  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
123819982  C5; complement C5 isoform X1 [KO:K03994]
123820165  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
123820205  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123820247  GSN; gelsolin isoform X1 [KO:K05768]
123820578  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
123820586  ITGA4; integrin alpha-4 [KO:K06483]
123820715  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
123820917  PXN; paxillin isoform X1 [KO:K05760]
123820996  VCL; vinculin isoform X1 [KO:K05700]
123821064  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
123821109  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123821608  [KO:K05764]
123821679  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
123822139  EZR; ezrin isoform X1 [KO:K08007]
123822396  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
123822478  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
123822504  CYRIA; CYFIP-related Rac1 interactor A [KO:K27976]
123822785  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
123822789  FGF9; fibroblast growth factor 9 [KO:K04358]
123822821  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
123822897  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
123823384  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
123823406  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
123823427  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
123823486  C8G; complement component C8 gamma chain [KO:K03999]
123823518  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
123823555  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
123823676  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123823743  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123823859  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
123824106  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123824296  MSN; moesin [KO:K05763]
123824324  [KO:K04275]
123824352  FGF16; fibroblast growth factor 16 [KO:K04358]
123824362  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
123824520  [KO:K04513]
123824527  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123824601  C6; complement component C6 isoform X1 [KO:K03995]
123824619  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
123824689  C7; complement component C7 [KO:K03996]
123824873  F2R; proteinase-activated receptor 1 [KO:K03914]
123824966  C9; complement component C9 [KO:K04000]
123825258  CFL2; cofilin-2 isoform X1 [KO:K05765]
123825513  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
123825521  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
123825523  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123825537  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
123825587  ITGAX; LOW QUALITY PROTEIN: integrin alpha-X [KO:K06462]
123825589  [KO:K06594]
123825630  [KO:K04409] [EC:2.7.11.1]
123826024  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
123826253  [KO:K12757]
123826263  [KO:K12757]
123826750  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123826812  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
123826853  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123827040  ITGB5; integrin beta-5 [KO:K06588]
123827047  [KO:K03898]
123827110  ABI2; abl interactor 2 isoform X1 [KO:K05751]
123827144  [KO:K03898]
123827292  PFN2; profilin-2 isoform X1 [KO:K05759]
123827960  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
123828067  ITGB2; integrin beta-2 [KO:K06464]
123828226  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
123828273  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123828291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123828441  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123828462  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123828624  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
123828686  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
123828714  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123828736  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
123828974  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123829212  FGF3; fibroblast growth factor 3 [KO:K04358]
123829213  FGF19; fibroblast growth factor 19 [KO:K22603]
123829436  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123829462  CFL1; cofilin-1 [KO:K05765]
123829523  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
123829560  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
123829593  FGF4; fibroblast growth factor 4 [KO:K04358]
123829653  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123829775  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
123829917  FN1; fibronectin isoform X1 [KO:K05717]
123830016  TMSB4X; thymosin beta-4 [KO:K05764]
123830199  MYH14; myosin-14 isoform X1 [KO:K10352]
123830210  FGF21; fibroblast growth factor 21 isoform X1 [KO:K22429]
123830304  RRAS; ras-related protein R-Ras [KO:K07829]
123830380  RHOA; transforming protein RhoA [KO:K04513]
123830492  ITGA9; integrin alpha-9 [KO:K06585]
123830565  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123830706  C8B; complement component C8 beta chain [KO:K03998]
123830760  MRAS; ras-related protein M-Ras [KO:K07831]
123831184  ITGA8; integrin alpha-8 [KO:K06584]
123831216  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
123831289  FGF5; fibroblast growth factor 5 [KO:K04358]
123831661  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
123831774  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
123831818  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
123831835  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123831922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123832297  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123832298  [KO:K02649]
123832643  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
123832777  ENAH; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
123832876  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
123833097  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
123833261  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
phas04010  MAPK signaling pathway
phas04510  Focal adhesion
phas04520  Adherens junction
KO pathway
ko04810   

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