KEGG   PATHWAY: pleu03320
Entry
pleu03320                   Pathway                                
Name
PPAR signaling pathway - Peromyscus leucopus (white-footed mouse)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
pleu03320  PPAR signaling pathway
pleu03320

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680724  Acox2; peroxisomal acyl-coenzyme A oxidase 2 isoform X1 [KO:K10214] [EC:1.17.99.3]
114680796  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114682086  Slc27a1; long-chain fatty acid transport protein 1 isoform X2 [KO:K08745] [EC:6.2.1.-]
114682502  [KO:K07513] [EC:2.3.1.16]
114682509  [KO:K07513] [EC:2.3.1.16]
114682947  Ubb; LOW QUALITY PROTEIN: polyubiquitin-B [KO:K08770]
114683597  Gk; glycerol kinase isoform X1 [KO:K00864] [EC:2.7.1.30]
114683843  Ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
114684255  Ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
114684350  Cpt1c; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
114684664  [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
114685079  Plin4; LOW QUALITY PROTEIN: perilipin-4 [KO:K20254]
114685100  Plin5; perilipin-5 [KO:K20255]
114685327  Angptl4; angiopoietin-related protein 4 [KO:K08767]
114685421  Apoa2; apolipoprotein A-II [KO:K08758]
114685580  Fabp1; fatty acid-binding protein, liver [KO:K08750]
114686258  [KO:K01641] [EC:2.3.3.10]
114686359  Rxrb; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
114686695  [KO:K00489] [EC:1.14.14.23]
114687893  [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
114688198  Hmgcs2; hydroxymethylglutaryl-CoA synthase, mitochondrial [KO:K01641] [EC:2.3.3.10]
114688577  Acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:K15013] [EC:6.2.1.3]
114688578  [KO:K15013] [EC:6.2.1.3]
114689632  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
114689885  Fabp6; gastrotropin [KO:K08755]
114689910  Rxrg; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
114690293  Acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1 [KO:K15013] [EC:6.2.1.3]
114691212  Apoa1; apolipoprotein A-I [KO:K08757]
114691213  Apoa5; apolipoprotein A-V [KO:K09025]
114691297  Apoc3; apolipoprotein C-III [KO:K08759]
114691450  [KO:K08762]
114692546  Fabp7; fatty acid-binding protein, brain [KO:K08756]
114692629  [KO:K08761]
114693032  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
114693617  Acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
114694545  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
114694795  [KO:K00864] [EC:2.7.1.30]
114695743  Gk2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
114695894  [KO:K01641] [EC:2.3.3.10]
114696151  Plin1; perilipin-1 [KO:K08768]
114697057  Acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
114697106  Adipoq; adiponectin isoform X2 [KO:K07296]
114697290  Me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
114698329  Acsl4; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
114699201  Ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
114699453  [KO:K00489] [EC:1.14.14.23]
114699685  Nr1h3; oxysterols receptor LXR-alpha isoform X2 [KO:K08536]
114699854  Acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
114700394  Acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
114701182  Acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
114701374  [KO:K08751]
114701375  [KO:K08751]
114701414  Olr1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
114701636  Ucp1; LOW QUALITY PROTEIN: mitochondrial brown fat uncoupling protein 1 [KO:K08769]
114702051  Acox3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
114702759  Slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
114702794  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
114703117  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
114703252  Aqp7; aquaporin-7 isoform X1 [KO:K08771]
114703305  Acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
114703436  Fads2; acyl-CoA 6-desaturase [KO:K10226] [EC:1.14.19.3]
114703883  Slc27a5; bile acyl-CoA synthetase [KO:K08748] [EC:6.2.1.7]
114704248  Hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2 [KO:K01641] [EC:2.3.3.10]
114705619  Fabp5; fatty acid-binding protein 5 isoform X1 [KO:K08754]
114705622  Fabp4; fatty acid-binding protein, adipocyte [KO:K08753]
114705633  Fabp3; fatty acid-binding protein, heart [KO:K08752]
114706127  Ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
114706193  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
114706215  Scp2; non-specific lipid-transfer protein isoform X1 [KO:K08764] [EC:2.3.1.176]
114706402  [KO:K08752]
114706427  [KO:K00507] [EC:1.14.19.1]
114706429  [KO:K00507] [EC:1.14.19.1]
114706443  [KO:K00507] [EC:1.14.19.1]
114706710  [KO:K07425] [EC:1.14.14.80]
114706721  [KO:K07425] [EC:1.14.14.80]
114706732  [KO:K07425] [EC:1.14.14.80]
114706896  Sorbs1; LOW QUALITY PROTEIN: sorbin and SH3 domain-containing protein 1 [KO:K06086]
114707102  Acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X3 [KO:K00232] [EC:1.3.3.6]
114707690  [KO:K07431] [EC:1.14.14.139]
114708012  Mmp1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
114708114  [KO:K00507] [EC:1.14.19.1]
114708128  [KO:K00507] [EC:1.14.19.1]
114708130  [KO:K00507] [EC:1.14.19.1]
114708147  [KO:K00507] [EC:1.14.19.1]
114708224  Cd36; platelet glycoprotein 4 [KO:K06259]
114708715  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
114709078  Slc27a2; very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
114709306  [KO:K00488] [EC:1.14.15.15]
114709731  [KO:K08749]
114709825  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
114709938  Dbi; acyl-CoA-binding protein [KO:K08762]
114710194  Ubc; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
114710503  [KO:K08762]
114710710  Me3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
119088219  [KO:K08751]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
pleu00071  Fatty acid degradation
pleu00120  Primary bile acid biosynthesis
pleu00564  Glycerophospholipid metabolism
pleu04920  Adipocytokine signaling pathway
KO pathway
ko03320   

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