KEGG   PATHWAY: ppad00600
Entry
ppad00600                   Pathway                                
Name
Sphingolipid metabolism - Panthera pardus (leopard)
Class
Metabolism; Lipid metabolism
Pathway map
ppad00600  Sphingolipid metabolism
ppad00600

Module
ppad_M00066  Lactosylceramide biosynthesis [PATH:ppad00600]
ppad_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:ppad00600]
ppad_M00094  Ceramide biosynthesis [PATH:ppad00600]
ppad_M00099  Sphingosine biosynthesis [PATH:ppad00600]
ppad_M00100  Sphingosine degradation [PATH:ppad00600]
Other DBs
GO: 0006665
Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109275512  SPTLC1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
109253902  SPTLC2; serine palmitoyltransferase 2 isoform X1 [KO:K00654] [EC:2.3.1.50]
109274699  SPTLC3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
109275583  KDSR; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
109247644  CERS1; ceramide synthase 1 isoform X1 [KO:K04710] [EC:2.3.1.299]
109257029  CERS2; ceramide synthase 2 isoform X1 [KO:K24621] [EC:2.3.1.297]
109254210  CERS4; ceramide synthase 4 [KO:K24621] [EC:2.3.1.297]
109273347  CERS3; ceramide synthase 3 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
109272468  CERS6; ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
109249101  CERS5; ceramide synthase 5 isoform X1 [KO:K23727] [EC:2.3.1.291]
109277196  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
109255388  ASAH2; neutral ceramidase isoform X1 [KO:K12349] [EC:3.5.1.23]
109247057  ACER2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
109255982  ACER1; alkaline ceramidase 1 isoform X1 [KO:K01441] [EC:3.5.1.23]
109267240  ACER3; alkaline ceramidase 3 isoform X1 [KO:K04711] [EC:3.5.1.-]
109274554  DEGS2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
109258915  DEGS1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
109247772  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
109255389  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
109271061  SMPD1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
109263521  SMPD2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
109270723  SMPD3; sphingomyelin phosphodiesterase 3 isoform X1 [KO:K12352] [EC:3.1.4.12]
109258618  SMPD4; sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
109276822  ENPP7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 isoform X1 [KO:K12354] [EC:3.1.4.12]
109278290  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
109265253  CERK; ceramide kinase [KO:K04715] [EC:2.7.1.138]
109266799  PLPP3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
109257719  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
109246335  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
109268345  SGPP1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
109264996  SGPP2; sphingosine-1-phosphate phosphatase 2 isoform X1 [KO:K04717] [EC:3.1.3.-]
109253123  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
109276896  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
109264372  SGPL1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
109269973  UGCG; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
109256251  GBA; glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
109270162  GBA2; non-lysosomal glucosylceramidase isoform X1 [KO:K17108] [EC:3.2.1.45]
109276438  B4GALT6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
109272301  B4GALT5; beta-1,4-galactosyltransferase 5 isoform X1 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
109248704  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
109248503  UGT8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
109274421  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
109253593  GAL3ST1; galactosylceramide sulfotransferase isoform X1 [KO:K01019] [EC:2.8.2.11]
109265790  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
109260509  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
109267196  NEU3; sialidase-3 isoform X1 [KO:K12357] [EC:3.2.1.18]
109264710  NEU4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
109264889  NEU2; sialidase-2 [KO:K12357] [EC:3.2.1.18]
109258839  GLA; alpha-galactosidase A isoform X1 [KO:K01189] [EC:3.2.1.22]
109270387  B4GALNT1; beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1 [KO:K00725] [EC:2.4.1.92]
109275001  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
109262730  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
109275980  GM2A; ganglioside GM2 activator [KO:K12383]
109264383  PSAP; prosaposin isoform X1 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
ppad00260  Glycine, serine and threonine metabolism
ppad00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ppad00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ppad00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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