KEGG   PATHWAY: pvp04145
Entry
pvp04145                    Pathway                                
Name
Phagosome - Pteropus vampyrus (large flying fox)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
pvp04145  Phagosome
pvp04145

Other DBs
GO: 0045335
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105297682  VAMP3; LOW QUALITY PROTEIN: vesicle-associated membrane protein 3 [KO:K13505]
105290520  STX12; syntaxin-12 [KO:K13813]
105291175  STX7; syntaxin-7 [KO:K08488]
105310641  syntaxin-7 [KO:K08488]
105301152  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105294565  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105304567  CORO1A; coronin-1A isoform X1 [KO:K13882]
105301840  STX18; syntaxin-18 [KO:K08492]
105296337  vesicle-trafficking protein SEC22b [KO:K08517]
105305341  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
105293481  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751]
105309601  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
105309848  HLA class I histocompatibility antigen, B-38 alpha chain-like isoform X2 [KO:K06751]
105309864  HLA class I histocompatibility antigen, B-54 alpha chain-like [KO:K06751]
105310129  HLA class I histocompatibility antigen, B-40 alpha chain-like [KO:K06751]
105311725  HLA class I histocompatibility antigen, B-54 alpha chain-like [KO:K06751]
105305274  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
105305333  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
105301039  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
105301004  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
105300960  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
105300961  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
105300962  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
105300964  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
105300969  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
105300971  HLA class II histocompatibility antigen, DM alpha chain isoform X3 [KO:K06752]
105300973  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
105309227  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
105310204  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
105310338  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
105289298  RAB5A; ras-related protein Rab-5A [KO:K07887]
105302599  RAB5B; ras-related protein Rab-5B [KO:K07888]
105306300  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
105293270  EEA1; early endosome antigen 1 [KO:K12478]
105292883  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
105309732  TFRC; transferrin receptor protein 1 [KO:K06503]
105301172  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
105303967  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105296552  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
105295753  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
105295447  ATP6V1C2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 2 [KO:K02148]
105300870  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
105309961  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
105297242  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105292922  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105290186  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
105296889  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
105305327  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
105292645  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
105299305  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
105289362  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105306292  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105306565  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105291621  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105305719  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
105302744  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
105291392  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
105303358  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105297098  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
105302499  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105309691  RAB7A; ras-related protein Rab-7a [KO:K07897]
105300653  RAB7B; ras-related protein Rab-7b [KO:K07898]
105291859  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
105299290  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
105297468  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
105290458  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
105294239  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
105305690  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
105293343  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
105297234  TUBA8; tubulin alpha-8 chain [KO:K07374]
105297536  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
105297537  tubulin alpha-1B chain-like [KO:K07374]
105297584  tubulin alpha-1C chain-like [KO:K07374]
105291036  tubulin alpha-4A chain [KO:K07374]
105291037  tubulin alpha-1B chain-like [KO:K07374]
105296776  tubulin beta-2A chain [KO:K07375]
105304852  TUBB3; tubulin beta-3 chain [KO:K07375]
105298557  TUBB4B; tubulin beta-4B chain [KO:K07375]
105306353  TUBB6; tubulin beta-6 chain [KO:K07375]
105308138  TUBB; tubulin beta chain [KO:K07375]
105301083  TUBB4A; tubulin beta-4A chain [KO:K07375]
105310590  LOW QUALITY PROTEIN: tubulin beta-1 chain-like [KO:K07375]
105296085  TUBB1; tubulin beta-1 chain [KO:K07375]
105304249  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
105305083  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
105298393  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2 [KO:K00921] [EC:2.7.1.150]
105295915  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
105289401  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105302124  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
105306474  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
105306921  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
105308899  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105303820  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
105291703  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
105310323  SEC61A1; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
105296248  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
105304388  protein transport protein Sec61 subunit gamma-like [KO:K07342]
105306139  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
105300966  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
105301037  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105307175  CALR; calreticulin [KO:K08057]
105299968  CANX; calnexin [KO:K08054]
105309973  high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06498]
105303406  low affinity immunoglobulin gamma Fc region receptor II-b-like isoform X1 [KO:K12560]
105303404  low affinity immunoglobulin gamma Fc region receptor III-B-like isoform X1 [KO:K06463]
105295937  C1R; LOW QUALITY PROTEIN: complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
105304501  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105303028  ITGB2; integrin beta-2 [KO:K06464]
105301109  C3; complement C3 [KO:K03990]
105301658  COLEC11; collectin-11 [KO:K10066]
105292314  COLEC12; collectin-12 [KO:K10062]
105288896  LOW QUALITY PROTEIN: mannose-binding protein A-like [KO:K03991]
105293124  MBL2; mannose-binding protein C [KO:K03991]
105288897  pulmonary surfactant-associated protein A-like isoform X2 [KO:K10067]
105288895  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
105289673  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
105307927  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105302702  ITGA5; integrin alpha-5 [KO:K06484]
105303008  ITGB1; integrin beta-1 [KO:K05719]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105297528  ITGB5; integrin beta-5 [KO:K06588]
105288620  THBS1; thrombospondin-1 [KO:K16857]
105296367  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105296582  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105303667  THBS4; thrombospondin-4 [KO:K04659]
105303727  THBS2; thrombospondin-2 [KO:K04659]
105291526  TLR2; toll-like receptor 2 [KO:K10159]
105295872  TLR6; toll-like receptor 6 [KO:K10169]
105292652  TLR4; toll-like receptor 4 [KO:K10160]
105306974  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105292117  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
105297736  MRC2; C-type mannose receptor 2 [KO:K06560]
105294936  MRC1; macrophage mannose receptor 1 [KO:K06560]
105307726  CD209; LOW QUALITY PROTEIN: CD209 antigen [KO:K06563]
105307727  CD209 antigen-like protein C [KO:K06563]
105295897  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
105295550  MSR1; macrophage scavenger receptor types I and II [KO:K06558]
105296129  MARCO; macrophage receptor MARCO [KO:K13884]
105295896  OLR1; oxidized low-density lipoprotein receptor 1 isoform X2 [KO:K08763]
105306721  SCARB1; scavenger receptor class B member 1 [KO:K13885]
105295518  CD36; platelet glycoprotein 4 [KO:K06259]
105299919  cytochrome b-245 light chain [KO:K08009]
105308561  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105299667  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
105295040  NCF2; neutrophil cytosol factor 2 [KO:K08010]
105288306  NCF4; neutrophil cytosol factor 4 [KO:K08012]
105310426  neutrophil cytosol factor 4-like [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
pvp04142  Lysosome
pvp04144  Endocytosis
pvp04610  Complement and coagulation cascades
pvp04612  Antigen processing and presentation
pvp04620  Toll-like receptor signaling pathway
pvp04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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