Entry
Name
Lysosome biogenesis - Pteropus vampyrus (large flying fox)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Other DBs
Organism
Pteropus vampyrus (large flying fox) [GN:
pvp ]
Gene
105288495 SLC29A1; equilibrative nucleoside transporter 1 isoform X1 [KO:K15014 ]
105288647 VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181 ]
105288723 BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188 ]
105289189 VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
105289214 VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467 ]
105289312 SNAP29; synaptosomal-associated protein 29 isoform X1 [KO:K08509 ]
105289362 ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
105289783 LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
105289975 OSBPL6; oxysterol-binding protein-related protein 6 isoform X2 [KO:K20463 ]
105290929 LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363 ]
105291003 MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455 ]
105291065 SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347 ]
105291621 ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
105292268 OSBPL1A; oxysterol-binding protein-related protein 1 isoform X2 [KO:K20174 ]
105292513 OSTM1; osteopetrosis-associated transmembrane protein 1 [KO:K23863 ]
105293349 GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404 ]
105293465 MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307 ]
105294201 SLC36A4; proton-coupled amino acid transporter 4 isoform X1 [KO:K14209 ]
105294316 VPS13C; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 13C [KO:K19525 ]
105295447 ATP6V1C2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 2 [KO:K02148 ]
105295753 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
105296552 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
105296752 BLOC1S5; biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X1 [KO:K20187 ]
105297098 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661 ]
105297415 BLOC1S3; biogenesis of lysosome-related organelles complex 1 subunit 3 [KO:K20186 ]
105297565 SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398 ]
105297942 SLC29A2; equilibrative nucleoside transporter 2 isoform X5 [KO:K15014 ]
105298321 VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
105298591 SLC2A6; solute carrier family 2, facilitated glucose transporter member 6 isoform X2 [KO:K08144 ]
105298609 ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
105298757 LAMP5; lysosome-associated membrane glycoprotein 5 isoform X1 [KO:K28774 ]
105299470 SLC36A1; proton-coupled amino acid transporter 1 isoform X1 [KO:K14209 ]
105299760 LAMTOR4; ragulator complex protein LAMTOR4 isoform X2 [KO:K20399 ]
105300104 VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466 ]
105300606 LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387 ]
105300870 ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148 ]
105301189 VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468 ]
105301864 TMEM175; endosomal/lysosomal potassium channel TMEM175 [KO:K24915 ]
105302461 VPS13A; vacuolar protein sorting-associated protein 13A [KO:K19525 ]
105302611 BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1 [KO:K20185 ]
105302932 VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466 ]
105303076 NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125 ] [EC:3.1.4.45 ]
105303203 VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
105303298 GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087 ]
105303305 TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137 ]
105303344 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
105303358 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
105303520 PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
105304249 LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
105304482 BLOC1S4; biogenesis of lysosome-related organelles complex 1 subunit 4 [KO:K08366 ]
105304621 BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X2 [KO:K16750 ]
105305675 IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564 ]
105305719 ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146 ]
105306292 ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
105306565 TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
105307269 OSBPL7; oxysterol-binding protein-related protein 7 isoform X1 [KO:K20463 ]
105307307 LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562 ]
105308113 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 [KO:K19027 ]
105308858 VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179 ]
105310616 GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X2 [KO:K08239 ] [EC:2.7.8.17 ]
105311584 GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404 ]
Compound
Reference
Authors
Eskelinen EL, Tanaka Y, Saftig P
Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal
Reference
Authors
Neufeld EF
Title
Lysosomal storage diseases.
Journal
Reference
Authors
von Figura K, Hasilik A
Title
Lysosomal enzymes and their receptors.
Journal
Reference
Authors
Janvier K, Bonifacino JS
Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal
Reference
Authors
Vergarajauregui S, Puertollano R
Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal
Reference
Authors
Jaskolka MC, Winkley SR, Kane PM
Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal
Reference
Authors
Majdoul S, Compton AA
Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal
Reference
Authors
Saftig P, Klumperman J
Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
Journal
Reference
Authors
Savini M, Zhao Q, Wang MC
Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
Journal
Reference
Authors
Meyer-Schwesinger C
Title
Lysosome function in glomerular health and disease.
Journal
Reference
Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
Journal
Reference
Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
Journal
Reference
Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
Title
The host mannose-6-phosphate pathway and viral infection.
Journal
Reference
Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
Journal
Reference
Authors
Radulovic M, Yang C, Stenmark H
Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
Journal
Reference
Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
Journal
Related pathway
pvp04130 SNARE interactions in vesicular transport
pvp04620 Toll-like receptor signaling pathway
KO pathway