KEGG   PATHWAY: pvp04142
Entry
pvp04142                    Pathway                                
Name
Lysosome biogenesis - Pteropus vampyrus (large flying fox)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
pvp04142  Lysosome biogenesis
pvp04142

Other DBs
GO: 0005764
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288426  TFEB; transcription factor EB [KO:K15590]
105288495  SLC29A1; equilibrative nucleoside transporter 1 isoform X1 [KO:K15014]
105288647  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
105288671  VPS39; vam6/Vps39-like protein [KO:K20183]
105288692  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
105288707  SPG11; spatacsin isoform X4 [KO:K19026]
105288723  BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188]
105288749  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
105288817  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
105288871  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
105288964  PSAP; prosaposin [KO:K12382]
105289067  DNASE2B; LOW QUALITY PROTEIN: deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
105289071  CTBS; di-N-acetylchitobiase [KO:K12310] [EC:3.2.1.-]
105289074  MCOLN2; mucolipin-2 [KO:K04993]
105289075  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
105289145  [KO:K12310] [EC:3.2.1.-]
105289189  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
105289214  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
105289240  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
105289312  SNAP29; synaptosomal-associated protein 29 isoform X1 [KO:K08509]
105289362  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105289370  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
105289410  CLTCL1; LOW QUALITY PROTEIN: clathrin heavy chain 2 [KO:K04646]
105289448  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
105289783  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
105289975  OSBPL6; oxysterol-binding protein-related protein 6 isoform X2 [KO:K20463]
105290029  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
105290139  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
105290167  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
105290186  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
105290226  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
105290258  GPR155; integral membrane protein GPR155 isoform X1 [KO:K28455]
105290457  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
105290693  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
105290850  AP3S1; AP-3 complex subunit sigma-1 [KO:K12399]
105290857  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
105290929  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
105291003  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
105291065  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
105291152  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
105291219  CD68; macrosialin isoform X2 [KO:K06501]
105291247  BORCS6; BLOC-1-related complex subunit 6 [KO:K20820]
105291392  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
105291573  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
105291621  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105291816  CTNS; cystinosin isoform X1 [KO:K12386]
105292226  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
105292254  [KO:K20402]
105292268  OSBPL1A; oxysterol-binding protein-related protein 1 isoform X2 [KO:K20174]
105292308  NPC1; Niemann-Pick C1 protein [KO:K12385]
105292366  SCARB2; lysosome membrane protein 2 isoform X1 [KO:K12384]
105292391  [KO:K08515]
105292513  OSTM1; osteopetrosis-associated transmembrane protein 1 [KO:K23863]
105292645  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
105292739  WDR7; WD repeat-containing protein 7 isoform X2 [KO:K24738]
105292922  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105293028  MANBA; beta-mannosidase isoform X4 [KO:K01192] [EC:3.2.1.25]
105293038  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105293102  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
105293204  OSBPL3; oxysterol-binding protein-related protein 3 [KO:K20463]
105293349  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
105293465  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
105293528  CLTB; clathrin light chain B [KO:K04645]
105293947  DTNBP1; dysbindin isoform X1 [KO:K20189]
105293980  TLR7; toll-like receptor 7 [KO:K05404]
105293981  TLR8; toll-like receptor 8 [KO:K10170]
105294005  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
105294191  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
105294201  SLC36A4; proton-coupled amino acid transporter 4 isoform X1 [KO:K14209]
105294316  VPS13C; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 13C [KO:K19525]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105294605  AP5Z1; AP-5 complex subunit zeta-1 [KO:K19025]
105294691  TLR3; toll-like receptor 3 [KO:K05401]
105294756  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
105295114  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
105295147  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
105295148  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
105295149  HYAL3; LOW QUALITY PROTEIN: hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
105295170  SUMF1; sulfatase-modifying factor 1 [KO:K13444] [EC:1.8.3.7]
105295240  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
105295246  CD164; sialomucin core protein 24 [KO:K06546]
105295447  ATP6V1C2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 2 [KO:K02148]
105295539  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
105295591  RRAGA; ras-related GTP-binding protein A [KO:K16185]
105295753  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
105295915  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
105296094  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
105296219  CLTA; clathrin light chain A [KO:K04644]
105296251  STX17; syntaxin-17 [KO:K08491]
105296351  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
105296369  GBA; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
105296514  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
105296552  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
105296566  BORCS8; BLOC-1-related complex subunit 8 [KO:K20822]
105296591  KXD1; kxDL motif-containing protein 1 isoform X1 [KO:K20818]
105296650  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
105296748  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
105296752  BLOC1S5; biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X1 [KO:K20187]
105296889  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
105296976  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
105297046  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
105297098  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
105297242  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105297275  SORT1; sortilin [KO:K12388]
105297318  AP2S1; AP-2 complex subunit sigma [KO:K11827]
105297415  BLOC1S3; biogenesis of lysosome-related organelles complex 1 subunit 3 [KO:K20186]
105297565  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
105297747  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
105297912  AP5B1; AP-5 complex subunit beta-1 isoform X2 [KO:K19022]
105297919  CTSW; cathepsin W isoform X2 [KO:K08569] [EC:3.4.22.-]
105297942  SLC29A2; equilibrative nucleoside transporter 2 isoform X5 [KO:K15014]
105297949  CTSF; LOW QUALITY PROTEIN: cathepsin F [KO:K01373] [EC:3.4.22.41]
105297980  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
105298028  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
105298196  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
105298321  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
105298393  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2 [KO:K00921] [EC:2.7.1.150]
105298515  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
105298529  AP5S1; AP-5 complex subunit sigma-1 [KO:K19024]
105298591  SLC2A6; solute carrier family 2, facilitated glucose transporter member 6 isoform X2 [KO:K08144]
105298609  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
105298757  LAMP5; lysosome-associated membrane glycoprotein 5 isoform X1 [KO:K28774]
105298852  TLDC1; TLD domain-containing protein 1 isoform X1 [KO:K27947]
105298937  ABCA5; ATP-binding cassette sub-family A member 5 [KO:K05648]
105299234  NPC2; epididymal secretory protein E1 [KO:K13443]
105299305  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
105299369  [KO:K14995]
105299465  GM2A; ganglioside GM2 activator [KO:K12383]
105299466  SLC36A3; proton-coupled amino acid transporter 3 [KO:K14209]
105299467  SLC36A2; proton-coupled amino acid transporter 2 [KO:K14209]
105299470  SLC36A1; proton-coupled amino acid transporter 1 isoform X1 [KO:K14209]
105299519  OSBPL5; oxysterol-binding protein-related protein 5 [KO:K20464]
105299530  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
105299609  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
105299723  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
105299760  LAMTOR4; ragulator complex protein LAMTOR4 isoform X2 [KO:K20399]
105299912  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
105300104  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
105300127  SLC29A3; equilibrative nucleoside transporter 3 [KO:K15014]
105300456  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
105300511  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
105300551  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
105300555  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
105300606  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
105300736  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
105300792  LGMN; LOW QUALITY PROTEIN: legumain [KO:K01369] [EC:3.4.22.34]
105300796  TMEM251; transmembrane protein 251 isoform X1 [KO:K26747]
105300870  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
105300952  AP1B1; AP-1 complex subunit beta-1 [KO:K12392]
105301026  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
105301186  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105301189  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
105301409  OSBPL2; oxysterol-binding protein-related protein 2 [KO:K20174]
105301620  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
105301716  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
105301726  AKT1S1; proline-rich AKT1 substrate 1 isoform X2 [KO:K16184]
105301729  AP2A1; AP-2 complex subunit alpha-1 [KO:K11824]
105301864  TMEM175; endosomal/lysosomal potassium channel TMEM175 [KO:K24915]
105301866  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
105302106  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
105302121  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
105302163  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
105302461  VPS13A; vacuolar protein sorting-associated protein 13A [KO:K19525]
105302499  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105302516  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
105302610  CD63; CD63 antigen [KO:K06497]
105302611  BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1 [KO:K20185]
105302744  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
105302797  BORCS5; BLOC-1-related complex subunit 5 isoform X1 [KO:K20819]
105302863  AP3B2; AP-3 complex subunit beta-2 isoform X2 [KO:K12397]
105302932  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
105303046  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
105303076  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
105303078  ROGDI; protein rogdi homolog isoform X2 [KO:K24628]
105303203  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
105303298  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
105303301  CLCN7; H(+)/Cl(-) exchange transporter 7 [KO:K05016]
105303305  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
105303344  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
105303358  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105303520  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
105303556  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
105303660  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
105303820  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
105303821  CTSK; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
105303967  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105304064  PPT1; palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
105304175  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
105304249  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
105304369  CLN8; protein CLN8 isoform X2 [KO:K12360]
105304482  BLOC1S4; biogenesis of lysosome-related organelles complex 1 subunit 4 [KO:K08366]
105304492  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
105304574  CLN3; battenin isoform X3 [KO:K12389]
105304621  BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X2 [KO:K16750]
105304713  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
105304972  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
105305041  SLC15A3; solute carrier family 15 member 3 [KO:K14638]
105305054  OSBP; oxysterol-binding protein 1 [KO:K20456]
105305083  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
105305184  AP3S2; AP-3 complex subunit sigma-2 [KO:K12399]
105305235  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
105305237  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
105305280  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
105305300  NEU1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
105305327  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
105305606  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
105305635  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
105305675  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
105305719  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
105305748  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
105305812  [KO:K14995]
105305844  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
105305962  AP2A2; AP-2 complex subunit alpha-2 [KO:K11824]
105306115  SLC17A5; sialin isoform X1 [KO:K12301]
105306154  SNAPIN; SNARE-associated protein Snapin [KO:K20002]
105306291  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
105306292  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105306386  RRAGC; ras-related GTP-binding protein C [KO:K16186]
105306474  [KO:K01365] [EC:3.4.22.15]
105306565  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105306724  SLC15A4; solute carrier family 15 member 4 [KO:K14638]
105306921  [KO:K01365] [EC:3.4.22.15]
105307108  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
105307155  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
105307170  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
105307269  OSBPL7; oxysterol-binding protein-related protein 7 isoform X1 [KO:K20463]
105307307  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
105307429  [KO:K04992]
105308056  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
105308113  ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 [KO:K19027]
105308268  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
105308858  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
105308899  [KO:K01365] [EC:3.4.22.15]
105308979  RRAGB; ras-related GTP-binding protein B isoform X7 [KO:K16185]
105309005  AP5M1; AP-5 complex subunit mu-1 isoform X1 [KO:K19023]
105309083  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
105309094  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
105309241  [KO:K08515]
105309409  [KO:K01319] [EC:3.4.21.20]
105309413  [KO:K01319] [EC:3.4.21.20]
105309494  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
105309650  BORCS7; BLOC-1-related complex subunit 7 isoform X1 [KO:K20821]
105309679  CLN6; ceroid-lipofuscinosis neuronal protein 6 [KO:K12359]
105309691  RAB7A; ras-related protein Rab-7a [KO:K07897]
105309961  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
105309972  [KO:K14077]
105309997  TFE3; transcription factor E3 isoform X1 [KO:K09105]
105310220  AP4M1; AP-4 complex subunit mu-1 isoform X2 [KO:K12402]
105310408  [KO:K20002]
105310616  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X2 [KO:K08239] [EC:2.7.8.17]
105310718  [KO:K07955]
105311411  [KO:K01195] [EC:3.2.1.31]
105311584  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
105311653  [KO:K01379] [EC:3.4.23.5]
105311654  [KO:K01379] [EC:3.4.23.5]
Compound
C00002  ATP
C00008  ADP
Reference
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Reference
  Authors
Saftig P, Klumperman J
  Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
  Journal
Nat Rev Mol Cell Biol 10:623-35 (2009)
DOI:10.1038/nrm2745
Reference
  Authors
Savini M, Zhao Q, Wang MC
  Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
  Journal
Trends Cell Biol 29:876-887 (2019)
DOI:10.1016/j.tcb.2019.08.008
Reference
  Authors
Meyer-Schwesinger C
  Title
Lysosome function in glomerular health and disease.
  Journal
Cell Tissue Res 385:371-392 (2021)
DOI:10.1007/s00441-020-03375-7
Reference
  Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
  Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
  Journal
Int J Nanomedicine 16:5065-5098 (2021)
DOI:10.2147/IJN.S321343
Reference
  Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
  Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
  Journal
Nat Commun 13:5351 (2022)
DOI:10.1038/s41467-022-33025-1
Reference
  Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
  Title
The host mannose-6-phosphate pathway and viral infection.
  Journal
Front Cell Infect Microbiol 14:1349221 (2024)
DOI:10.3389/fcimb.2024.1349221
Reference
  Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
  Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
  Journal
Med Res Rev 44:2472-2509 (2024)
DOI:10.1002/med.22047
Reference
  Authors
Radulovic M, Yang C, Stenmark H
  Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
  Journal
Nat Rev Mol Cell Biol 27:71-87 (2026)
DOI:10.1038/s41580-025-00873-w
Reference
  Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
  Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
  Journal
Nat Rev Mol Cell Biol 26:940-956 (2025)
DOI:10.1038/s41580-025-00907-3
Related
pathway
pvp00511  Other glycan degradation
pvp00531  Glycosaminoglycan degradation
pvp04130  SNARE interactions in vesicular transport
pvp04140  Autophagy - animal
pvp04144  Endocytosis
pvp04145  Phagosome
pvp04150  mTOR signaling pathway
pvp04620  Toll-like receptor signaling pathway
KO pathway
ko04142   

DBGET integrated database retrieval system