Entry Name Pancreatic secretion - Sarcophilus harrisii (Tasmanian devil)
Description The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Other DBs Organism Sarcophilus harrisii (Tasmanian devil) [GN:
shr ]
Gene 100913257 CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027 ]
100913495 SLC12A2; solute carrier family 12 member 2 isoform X1 [KO:K10951 ]
100914612 CTRL; chymotrypsin-like protease CTRL-1 [KO:K09632 ] [EC:3.4.21.-]
100915426 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
100915602 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
100916183 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
100916996 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960 ]
100918532 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X7 [KO:K04958 ]
100919657 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
100922504 KCNMA1; LOW QUALITY PROTEIN: calcium-activated potassium channel subunit alpha-1 [KO:K04936 ]
100929015 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100929307 FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X2 [KO:K01538 ]
100930666 GNAS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632 ]
100931490 CLCA2; calcium-activated chloride channel regulator 2 [KO:K05028 ]
100932658 KCNQ1; LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 1 [KO:K04926 ]
100933827 TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
100934049 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100934284 SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575 ]
100934311 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100935132 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540 ]
100935197 RAB8A; LOW QUALITY PROTEIN: ras-related protein Rab-8A [KO:K07901 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C13051 Nicotinic acid adenine dinucleotide phosphate
Reference Authors Petersen OH, Tepikin AV
Title Polarized calcium signaling in exocrine gland cells.
Journal Reference Authors Williams JA
Title Regulation of acinar cell function in the pancreas.
Journal Reference Authors Williams JA
Title Regulation of pancreatic acinar cell function.
Journal Reference Authors Bi Y, Williams JA
Title Receptor biology and signal transduction in pancreatic acinar cells.
Journal Reference Authors Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
Title Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
Journal Reference Authors Kanno T
Title Ca2+ signaling in the pancreatic acinus.
Journal Pancreas 16:273-6 (1998)
Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
Title Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
Journal Reference Authors Chu JY, Yung WH, Chow BK
Title Secretin: a pleiotrophic hormone.
Journal Reference Authors Siu FK, Lam IP, Chu JY, Chow BK
Title Signaling mechanisms of secretin receptor.
Journal Reference Authors Steward MC, Ishiguro H, Case RM
Title Mechanisms of bicarbonate secretion in the pancreatic duct.
Journal Reference Authors Kim D, Steward MC
Title The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
Journal Reference Authors Whitcomb DC, Lowe ME
Title Human pancreatic digestive enzymes.
Journal Reference Authors Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
Title Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
Journal Reference Authors Cancela JM, Churchill GC, Galione A
Title Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
Journal Reference Authors Parekh AB
Title Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
Journal Reference Authors Williams JA, Chen X, Sabbatini ME
Title Small G proteins as key regulators of pancreatic digestive enzyme secretion.
Journal Related shr04973 Carbohydrate digestion and absorption
shr04974 Protein digestion and absorption
shr04977 Vitamin digestion and absorption
KO pathway
