Entry Name mTOR signaling pathway - Sceloporus undulatus (fence lizard)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Sceloporus undulatus (fence lizard) [GN:
sund ]
Gene 121914538 SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780 ]
121914969 TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137 ]
121916019 SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519 ]
121916727 CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421 ]
121916968 CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081 ]
121919718 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
121921174 RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267 ]
121921457 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
121922423 EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259 ]
121922485 SLC38A9; LOW QUALITY PROTEIN: sodium-coupled neutral amino acid transporter 9 [KO:K14995 ]
121923252 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
121923808 STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532 ]
121924302 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
121925257 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121925478 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
121925596 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
121925693 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
121927270 SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099 ]
121927832 DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
121928669 PRKAA2; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198 ] [EC:2.7.11.31 ]
121930669 LRP6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
121931287 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
121931540 EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259 ]
121933363 DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
121934162 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
121934299 STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
121936258 CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080 ]
121936860 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
121936999 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410 ]
121937300 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
121937494 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related KO pathway
