Entry
Name
Homologous recombination - Tachysurus fulvidraco (yellow catfish)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Tachysurus fulvidraco (yellow catfish) [GN:
tfd ]
Gene
113645890 ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111 ]
113640330 mre11a; double-strand break repair protein MRE11 isoform X1 [KO:K10865 ]
113652818 rbbp8; DNA endonuclease RBBP8 isoform X3 [KO:K20773 ] [EC:3.1.-.-]
113661827 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728 ]
113647564 brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864 ] [EC:3.4.19.-]
113649412 brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775 ]
113643510 rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466 ]
113644653 rpa2; replication protein A 32 kDa subunit isoform X2 [KO:K10739 ]
113642790 rad54l; DNA repair and recombination protein RAD54-like [KO:K10875 ] [EC:5.6.2.-]
113659528 rad54b; DNA repair and recombination protein RAD54B [KO:K10877 ] [EC:5.6.2.-]
113635178 mus81; crossover junction endonuclease MUS81 [KO:K08991 ] [EC:3.1.22.-]
113648463 eme1; crossover junction endonuclease EME1 [KO:K10882 ] [EC:3.1.22.-]
Reference
Authors
Maloisel L, Fabre F, Gangloff S.
Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Journal
Reference
Authors
Haruta-Takahashi N, Iwasaki H.
Title
[Recombination mediators]
Journal
Seikagaku 79:449-53 (2007)
Reference
Authors
Ouyang KJ, Woo LL, Ellis NA.
Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Journal
Reference
Authors
Kawabata M, Kawabata T, Nishibori M.
Title
Role of recA/RAD51 family proteins in mammals.
Journal
Reference
Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Title
Mitotic recombination in Saccharomyces cerevisiae.
Journal
Reference
Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Title
Rad54: the Swiss Army knife of homologous recombination?
Journal
Reference
Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Title
Recombination proteins and rescue of arrested replication forks.
Journal
KO pathway
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