KEGG   PATHWAY: tfd03440
Entry
tfd03440                    Pathway                                
Name
Homologous recombination - Tachysurus fulvidraco (yellow catfish)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
tfd03440  Homologous recombination
tfd03440

Other DBs
GO: 0000724
Organism
Tachysurus fulvidraco (yellow catfish) [GN:tfd]
Gene
113645890  ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
113647527  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
113640330  mre11a; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
113646901  nbn; nibrin [KO:K10867]
113653740  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
113662646  breast cancer type 1 susceptibility protein homolog isoform X1 [KO:K10605] [EC:2.3.2.27]
113655910  BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
113652818  rbbp8; DNA endonuclease RBBP8 isoform X3 [KO:K20773] [EC:3.1.-.-]
113643762  brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
113661827  topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
113638627  abraxas1; BRCA1-A complex subunit Abraxas 1 [KO:K20774]
113662451  uimc1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
113657925  babam1; BRISC and BRCA1-A complex member 1 [KO:K20776]
113656926  babam2; BRISC and BRCA1-A complex member 2 [KO:K12173]
113647564  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
113640290  palb2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
113649412  brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
113636196  sycp3; synaptonemal complex protein 3 [KO:K19528]
113643510  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
113644653  rpa2; replication protein A 32 kDa subunit isoform X2 [KO:K10739]
113654688  replication protein A 32 kDa subunit-like isoform X1 [KO:K10739]
113658991  rpa3; replication protein A 14 kDa subunit [KO:K10740]
113651700  rad51; DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
113636169  rad52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
113650273  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
113663397  rad51d; DNA repair protein RAD51 homolog 4 [KO:K10871]
113656632  xrcc2; DNA repair protein XRCC2 isoform X1 [KO:K10879]
113644345  xrcc3; DNA repair protein XRCC3 [KO:K10880]
113642790  rad54l; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
113659528  rad54b; DNA repair and recombination protein RAD54B [KO:K10877] [EC:5.6.2.-]
113641171  pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
113656822  pold2; DNA polymerase delta subunit 2 [KO:K02328]
113651971  pold3; DNA polymerase delta subunit 3 [KO:K03504]
113642481  pold4; DNA polymerase delta subunit 4 [KO:K03505]
113652558  blm; Bloom syndrome protein homolog isoform X1 [KO:K10901] [EC:5.6.2.4]
113643970  top3a; DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
113653296  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
113635178  mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
113648463  eme1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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