KEGG   PATHWAY: tup04514
Entry
tup04514                    Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Tupaia chinensis (Chinese tree shrew)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
tup04514  Cell adhesion molecule (CAM) interaction
tup04514

Other DBs
GO: 0050839
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102467860  [KO:K06752]
102468193  CDH15; cadherin 15 [KO:K06809]
102468327  CLDN19; claudin 19 [KO:K06087]
102468609  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
102468690  [KO:K10784]
102468764  CD99L2; CD99 molecule like 2 [KO:K06520]
102469339  CD4; CD4 molecule [KO:K06454]
102469395  CLDN2; claudin 2 [KO:K06087]
102469419  JAM3; junctional adhesion molecule 3 [KO:K06785]
102469429  NEGR1; neuronal growth regulator 1 [KO:K06775]
102469446  ITGB7; integrin subunit beta 7 [KO:K06590]
102469543  ITGAL; integrin subunit alpha L [KO:K05718]
102469850  ITGAV; integrin subunit alpha V [KO:K06487]
102469865  [KO:K06752]
102470538  PECAM1; platelet and endothelial cell adhesion molecule 1 [KO:K06471]
102470549  SIGLEC1; sialoadhesin [KO:K06548]
102470678  LRRC4; leucine rich repeat containing 4 [KO:K16351]
102470813  [KO:K06752]
102471054  CLDN18; claudin 18 [KO:K06087]
102471268  [KO:K06752]
102471277  CD8B; CD8b molecule [KO:K06459]
102471700  CD8A; CD8a molecule [KO:K06458]
102471737  CNTNAP2; contactin associated protein-like 2 [KO:K07380]
102471858  CD276; CD276 molecule [KO:K06746]
102471945  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
102472004  CD6; CD6 molecule [KO:K06456]
102472009  CLDN8; claudin 8 [KO:K06087]
102472093  SLITRK2; SLIT and NTRK like family member 2 [KO:K25833]
102472115  [KO:K06752]
102472434  CLDN17; claudin 17 [KO:K06087]
102472509  CLDN11; claudin 11 [KO:K06087]
102472670  CD99; CD99 molecule [KO:K06520]
102472833  CADM1; cell adhesion molecule 1 [KO:K06781]
102472858  GLG1; golgi glycoprotein 1 [KO:K06816]
102472864  CLDN12; claudin 12 [KO:K06087]
102472948  SLITRK5; SLIT and NTRK like family member 5 [KO:K25836]
102472997  [KO:K06752]
102473125  [KO:K06751]
102473522  SPN; sialophorin [KO:K06477]
102474227  NRXN2; neurexin 2 [KO:K07377]
102474781  [KO:K06751]
102474808  L1CAM; L1 cell adhesion molecule [KO:K06550]
102474908  SLITRK6; SLIT and NTRK like family member 6 [KO:K25837]
102475038  NLGN3; neuroligin 3 [KO:K07378]
102475338  SLITRK1; SLIT and NTRK like family member 1 [KO:K25832]
102475979  CLDN23; claudin 23 [KO:K06087]
102476089  CLDN15; claudin 15 [KO:K06087]
102476100  CLDN10; claudin 10 [KO:K06087]
102476250  NRXN3; neurexin 3 [KO:K07377]
102476446  SLITRK4; SLIT and NTRK like family member 4 [KO:K25835]
102476466  LRRC4C; leucine rich repeat containing 4C [KO:K07523]
102476520  MAG; myelin associated glycoprotein [KO:K06771]
102476606  PTPRD; protein tyrosine phosphatase, receptor type D [KO:K06777] [EC:3.1.3.48]
102476637  OCLN; occludin [KO:K06088]
102476925  CD22; CD22 molecule [KO:K06467]
102477148  SELL; selectin L [KO:K06495]
102477179  NECTIN3; nectin cell adhesion molecule 3 [KO:K06592]
102477324  PTPRC; protein tyrosine phosphatase, receptor type C [KO:K06478] [EC:3.1.3.48]
102477414  [KO:K06751]
102477560  SELP; selectin P [KO:K06496]
102477711  [KO:K06752]
102477725  NLGN2; neuroligin 2 [KO:K07378]
102478258  [KO:K10784]
102478707  CD86; CD86 molecule [KO:K05413]
102479721  CD80; CD80 molecule [KO:K05412]
102479840  Tube-DRB; H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
102480238  [KO:K06752]
102480676  [KO:K06752]
102480985  CNTN1; contactin 1 [KO:K06759]
102481630  [KO:K10785]
102481864  PTPRS; receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
102482073  [KO:K06752]
102482093  [KO:K06751]
102482486  [KO:K06752]
102483105  CD28; CD28 molecule [KO:K06470]
102483518  CTLA4; cytotoxic T-lymphocyte associated protein 4 [KO:K06538]
102483521  ICOSLG; inducible T-cell costimulator ligand [KO:K06710]
102483623  ITGAM; integrin subunit alpha M [KO:K06461]
102483671  PTPRF; protein tyrosine phosphatase, receptor type F [KO:K05695] [EC:3.1.3.48]
102483735  [KO:K10785]
102484266  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
102484572  ALCAM; activated leukocyte cell adhesion molecule [KO:K06547]
102484668  JAM2; junctional adhesion molecule 2 [KO:K06735]
102484753  CLDN7; claudin 7 [KO:K06087]
102484826  ITGA8; integrin subunit alpha 8 [KO:K06584]
102485402  [KO:K10785]
102485684  CD2; CD2 molecule [KO:K06449]
102485720  [KO:K06752]
102486015  [KO:K06736]
102486164  [KO:K06752]
102486217  CNTNAP1; contactin associated protein 1 [KO:K07379]
102486266  [KO:K10785]
102486373  PVR; poliovirus receptor [KO:K06539]
102486539  [KO:K06087]
102486572  [KO:K06752]
102486955  VTCN1; V-set domain containing T cell activation inhibitor 1 [KO:K06747]
102487127  SELPLG; selectin P ligand [KO:K06544]
102487508  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
102487577  SDC4; syndecan 4 [KO:K16338]
102487875  CDH3; cadherin 3 [KO:K06796]
102487946  NTNG1; netrin G1 [KO:K07522]
102488139  NLGN1; neuroligin 1 [KO:K07378]
102488439  CLDN20; claudin 20 [KO:K06087]
102488449  CLDN16; claudin 16 [KO:K06087]
102488465  NECTIN2; nectin cell adhesion molecule 2 [KO:K06531]
102488470  NRXN1; neurexin 1 [KO:K07377]
102488619  CD40LG; CD40 ligand [KO:K03161]
102488870  CLDN1; claudin 1 [KO:K06087]
102489284  ITGB1; integrin subunit beta 1 [KO:K05719]
102489413  CD40; CD40 molecule [KO:K03160]
102489823  SDC3; syndecan 3 [KO:K16337]
102490219  CDH5; cadherin 5 [KO:K06533]
102490323  [KO:K06751]
102490572  [KO:K06751]
102490747  [KO:K06751]
102491061  CLDN3; claudin 3 [KO:K06087]
102491473  CLDN4; claudin 4 [KO:K06087]
102491637  MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
102491642  ESAM; endothelial cell adhesion molecule [KO:K06787]
102491861  NCAM1; neural cell adhesion molecule 1 [KO:K06491]
102492528  NLGN4X; neuroligin 4, X-linked [KO:K07378]
102492567  ITGA4; integrin subunit alpha 4 [KO:K06483]
102492852  VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
102492922  [KO:K06585]
102493443  [KO:K06752]
102493748  [KO:K06752]
102493767  F11R; F11 receptor [KO:K06089]
102493828  CADM3; cell adhesion molecule 3 [KO:K06780]
102493834  [KO:K06788]
102494250  [KO:K06751]
102494356  PDCD1; programmed cell death 1 [KO:K06744]
102494567  [KO:K06785]
102494720  CD58; CD58 molecule [KO:K06492]
102494722  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
102495199  ITGB8; integrin subunit beta 8 [KO:K06591]
102495272  [KO:K06752]
102495990  CLDN5; claudin 5 [KO:K06087]
102496148  [KO:K06752]
102496359  CLDN14; claudin 14 [KO:K06087]
102496941  [KO:K06751]
102496982  SDC1; syndecan 1 [KO:K06257]
102497134  ICOS; inducible T-cell costimulator [KO:K06713]
102497478  CD34; CD34 molecule [KO:K06474]
102497506  [KO:K06751]
102497567  [KO:K06464]
102497624  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102497674  SLITRK3; SLIT and NTRK like family member 3 [KO:K25834]
102497745  NFASC; neurofascin [KO:K06757]
102498024  [KO:K10784]
102498428  LRRC4B; leucine rich repeat containing 4B [KO:K16360]
102498495  [KO:K06752]
102498819  CDH4; cadherin 4 [KO:K06797]
102498905  CLDN25; claudin 25 [KO:K06087]
102499062  VSIR; V-set immunoregulatory receptor [KO:K23268]
102499120  SDC2; syndecan 2 [KO:K16336]
102499336  NEO1; neogenin 1 [KO:K06766]
102499381  CDH1; cadherin 1 [KO:K05689]
102499572  PTPRM; protein tyrosine phosphatase, receptor type M [KO:K05693] [EC:3.1.3.48]
102499993  CD226; CD226 molecule [KO:K06567]
102500039  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
102500081  ITGA6; integrin subunit alpha 6 [KO:K06485]
102500394  CLDN6; claudin 6 [KO:K06087]
102500713  PVRL1; nectin-1 [KO:K06081]
102500801  CLDN9; claudin 9 [KO:K06087]
102500826  JAML; junction adhesion molecule like [KO:K28137]
102500862  CD274; CD274 molecule [KO:K06745]
102501274  ITGB2; integrin beta-2 [KO:K06464]
102501374  [KO:K06751]
102501696  [KO:K06752]
102502020  CNTN2; contactin 2 [KO:K06760]
102502456  CLDN24; putative claudin-24 [KO:K06087]
102502625  MPZ; myelin protein zero [KO:K06770]
102502643  [KO:K06751]
102503084  CXADR; coxsackie virus and adenovirus receptor [KO:K06788]
102503183  NRCAM; neuronal cell adhesion molecule [KO:K06756]
102503204  [KO:K06752]
102503362  NTNG2; netrin G2 [KO:K16359]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
tup04520  Adherens junction
tup04530  Tight junction
tup04610  Complement and coagulation cascades
tup04660  T cell receptor signaling pathway
tup04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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