KEGG   PATHWAY: tup04530
Entry
tup04530                    Pathway                                
Name
Tight junction - Tupaia chinensis (Chinese tree shrew)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tup04530  Tight junction
tup04530

Other DBs
GO: 0005923
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102468222  DLG1; discs large MAGUK scaffold protein 1 [KO:K12076]
102468306  SYNPO; synaptopodin [KO:K21112]
102468327  CLDN19; claudin 19 [KO:K06087]
102468642  MYH10; myosin heavy chain 10 [KO:K10352]
102468661  EPB41L4B; erythrocyte membrane protein band 4.1 like 4B [KO:K21111]
102468752  ARHGEF18; Rho/Rac guanine nucleotide exchange factor 18 [KO:K21066]
102469132  WAS; Wiskott-Aldrich syndrome [KO:K05747]
102469395  CLDN2; claudin 2 [KO:K06087]
102469419  JAM3; junctional adhesion molecule 3 [KO:K06785]
102469825  SLC9A3R1; SLC9A3 regulator 1 [KO:K13365]
102470174  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102470367  DLG2; discs large MAGUK scaffold protein 2 [KO:K12075]
102470651  [KO:K07374]
102470799  [KO:K12757]
102471054  CLDN18; claudin 18 [KO:K06087]
102471120  MYL6B; myosin light chain 6B [KO:K12751]
102471174  BVES; blood vessel epicardial substance [KO:K21108]
102471322  TJP3; tight junction protein 3 [KO:K06097]
102471485  MPP5; membrane palmitoylated protein 5 [KO:K06091]
102471526  [KO:K12757]
102471560  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
102471830  MYL6; myosin light chain 6 [KO:K12751]
102471845  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
102471857  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
102472009  CLDN8; claudin 8 [KO:K06087]
102472106  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
102472233  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102472434  CLDN17; claudin 17 [KO:K06087]
102472485  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
102472509  CLDN11; claudin 11 [KO:K06087]
102472609  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
102472864  CLDN12; claudin 12 [KO:K06087]
102473466  CGNL1; cingulin like 1 [KO:K21110]
102473546  RDX; radixin [KO:K05762]
102474505  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
102474683  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
102474947  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
102475072  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102475730  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102475979  CLDN23; claudin 23 [KO:K06087]
102476089  CLDN15; claudin 15 [KO:K06087]
102476100  CLDN10; claudin 10 [KO:K06087]
102476593  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102476637  OCLN; occludin [KO:K06088]
102477154  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
102477219  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
102477318  MARVELD2; MARVEL domain containing 2 [KO:K17291]
102477439  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102477954  AFDN; afadin, adherens junction formation factor [KO:K05702]
102478144  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
102478525  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102478606  AMOT; angiomotin [KO:K16819]
102479102  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102479161  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102479926  ACTB; actin beta [KO:K05692]
102480185  TUBAL3; tubulin alpha like 3 [KO:K07374]
102480580  ARHGEF2; Rho/Rac guanine nucleotide exchange factor 2 [KO:K12791]
102480799  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102480902  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
102480946  MYH11; myosin heavy chain 11 [KO:K10352]
102480959  TJAP1; tight junction associated protein 1 [KO:K06105]
102480993  MICALL2; MICAL like 2 [KO:K21068]
102481136  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
102481330  TUBA8; tubulin alpha 8 [KO:K07374]
102481346  MYH14; myosin heavy chain 14 [KO:K10352]
102481524  PCNA; proliferating cell nuclear antigen [KO:K04802]
102481645  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
102481788  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102482323  GATA4; GATA binding protein 4 [KO:K09183]
102482678  TJP2; tight junction protein 2 [KO:K06098]
102482877  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
102483194  RAP2C; RAP2C, member of RAS oncogene family [KO:K07839]
102483224  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
102483320  MYL9; myosin light chain 9 [KO:K12755]
102483602  DLG3; discs large MAGUK scaffold protein 3 [KO:K21098]
102483890  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102484668  JAM2; junctional adhesion molecule 2 [KO:K06735]
102484753  CLDN7; claudin 7 [KO:K06087]
102484770  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102485306  YBX3; Y-box binding protein 3 [KO:K06099]
102485560  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102485790  NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
102485840  LLGL1; LLGL1, scribble cell polarity complex component [KO:K06094]
102486512  RAB8B; RAB8B, member RAS oncogene family [KO:K07902]
102486539  [KO:K06087]
102486767  CTTN; cortactin [KO:K06106]
102487039  RHOA; ras homolog family member A [KO:K04513]
102487164  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102487562  CGN; cingulin [KO:K06102]
102487950  [KO:K04382] [EC:3.1.3.16]
102487965  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
102488344  CDC42; cell division cycle 42 [KO:K04393]
102488439  CLDN20; claudin 20 [KO:K06087]
102488449  CLDN16; claudin 16 [KO:K06087]
102488546  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102488870  CLDN1; claudin 1 [KO:K06087]
102488880  SYMPK; symplekin [KO:K06100]
102489284  ITGB1; integrin subunit beta 1 [KO:K05719]
102489663  CRB3; crumbs 3, cell polarity complex component [KO:K06090]
102489916  WHAMM; WAS protein homolog associated with actin, golgi membranes and microtubules [KO:K20479]
102489974  CD1D; CD1d molecule [KO:K06448]
102490073  EZR; ezrin [KO:K08007]
102490242  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
102490651  CCND1; cyclin D1 [KO:K04503]
102490714  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102490845  AMOTL1; angiomotin like 1 [KO:K06104]
102491061  CLDN3; claudin 3 [KO:K06087]
102491119  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102491473  CLDN4; claudin 4 [KO:K06087]
102491657  CD1C; T-cell surface glycoprotein CD1c [KO:K06448]
102491696  ARHGAP17; Rho GTPase activating protein 17 [KO:K20638]
102491807  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102492072  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
102492330  [KO:K07374]
102492663  LLGL2; LLGL2, scribble cell polarity complex component [KO:K06094]
102492802  NF2; neurofibromin 2 [KO:K16684]
102492946  PATJ; PATJ, crumbs cell polarity complex component [KO:K06092]
102493060  RAB13; RAB13, member RAS oncogene family [KO:K06109]
102493291  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102493334  MSN; moesin [KO:K05763]
102493456  PARD3; par-3 family cell polarity regulator [KO:K04237]
102493767  F11R; F11 receptor [KO:K06089]
102493901  ACTN4; actinin alpha 4 [KO:K05699]
102494006  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
102494430  ACTN1; actinin alpha 1 [KO:K05699]
102494567  [KO:K06785]
102494910  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102495244  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102495457  MARVELD3; MARVEL domain containing 3 [KO:K21099]
102495919  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
102495990  CLDN5; claudin 5 [KO:K06087]
102496008  TUBA4A; tubulin alpha-4A chain [KO:K07374]
102496042  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
102496134  RUNX1; runt-related transcription factor 1 [KO:K08367]
102496359  CLDN14; claudin 14 [KO:K06087]
102496711  SCRIB; scribbled planar cell polarity protein [KO:K16175]
102496850  [KO:K07374]
102496870  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102496946  MPDZ; multiple PDZ domain crumbs cell polarity complex component [KO:K06095]
102497057  [KO:K06448]
102497079  AMOTL2; angiomotin like 2 [KO:K06104]
102497095  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102497477  CD1E; CD1e molecule [KO:K06448]
102497910  HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
102498064  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
102498431  ACTG1; actin gamma 1 [KO:K05692]
102498498  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
102498905  CLDN25; claudin 25 [KO:K06087]
102500173  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102500394  CLDN6; claudin 6 [KO:K06087]
102500520  [KO:K07839]
102500732  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102500733  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
102500801  CLDN9; claudin 9 [KO:K06087]
102501396  TUBA3E; tubulin alpha 3e [KO:K07374]
102501839  MPP4; membrane palmitoylated protein 4 [KO:K21109]
102502025  PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
102502097  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
102502102  TJP1; tight junction protein 1 [KO:K05701]
102502422  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102502456  CLDN24; putative claudin-24 [KO:K06087]
102502505  MYL2; myosin light chain 2 [KO:K10351]
102502506  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102502946  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
102502947  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
102503329  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
102503375  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
102503378  TUBA3D; tubulin alpha 3d [KO:K07374]
106733869  [KO:K07374]
106735707  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
tup04520  Adherens junction
tup04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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