KEGG   PATHWAY: xhe00600
Entry
xhe00600                    Pathway                                
Name
Sphingolipid metabolism - Xiphophorus hellerii (green swordtail)
Class
Metabolism; Lipid metabolism
Pathway map
xhe00600  Sphingolipid metabolism
xhe00600

Module
xhe_M00066  Lactosylceramide biosynthesis [PATH:xhe00600]
xhe_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:xhe00600]
xhe_M00094  Ceramide biosynthesis [PATH:xhe00600]
xhe_M00099  Sphingosine biosynthesis [PATH:xhe00600]
xhe_M00100  Sphingosine degradation [PATH:xhe00600]
Other DBs
GO: 0006665
Organism
Xiphophorus hellerii (green swordtail) [GN:xhe]
Gene
116707888  [KO:K04715] [EC:2.7.1.138]
116708203  [KO:K23727]
116708311  [KO:K24622]
116708894  plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
116708982  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
116709385  galc; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
116709596  [KO:K00654] [EC:2.3.1.50]
116709640  [KO:K04716] [EC:3.1.3.-]
116710398  [KO:K12353] [EC:3.1.4.12]
116710545  [KO:K12373] [EC:3.2.1.52]
116710610  smpd4; sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
116710701  cers5; ceramide synthase 5 [KO:K23727]
116710988  [KO:K00725] [EC:2.4.1.92]
116710989  [KO:K00725] [EC:2.4.1.92]
116711097  smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
116712798  degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
116713073  psap; prosaposin isoform X1 [KO:K12382]
116713366  sgpl1; sphingosine-1-phosphate lyase 1 isoform X1 [KO:K01634] [EC:4.1.2.27]
116713534  sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
116713560  sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
116714683  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
116714799  gm2a; ganglioside GM2 activator [KO:K12383]
116716877  [KO:K12354] [EC:3.1.4.12]
116717032  [KO:K12352] [EC:3.1.4.12]
116717124  [KO:K04718] [EC:2.7.1.91]
116717375  cers2; ceramide synthase 2 [KO:K24621]
116717823  gba; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
116718874  [KO:K24622]
116719553  asah1; LOW QUALITY PROTEIN: acid ceramidase [KO:K12348] [EC:3.5.1.23]
116719917  sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
116720056  [KO:K12309] [EC:3.2.1.23]
116720325  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
116720421  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
116720548  [KO:K12357] [EC:3.2.1.18]
116720660  [KO:K01080] [EC:3.1.3.4]
116720844  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
116721149  [KO:K01080] [EC:3.1.3.4]
116721301  kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
116721356  [KO:K24621]
116722749  cers6; ceramide synthase 6 [KO:K23727]
116723766  [KO:K12357] [EC:3.2.1.18]
116723830  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
116723859  [KO:K01019] [EC:2.8.2.11]
116723978  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
116724273  [KO:K12357] [EC:3.2.1.18]
116724274  [KO:K12357] [EC:3.2.1.18]
116724275  [KO:K12357] [EC:3.2.1.18]
116724277  [KO:K12357] [EC:3.2.1.18]
116724278  [KO:K12357] [EC:3.2.1.18]
116724309  plpp1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
116724957  [KO:K12382]
116725045  hexb; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
116725441  cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
116725986  [KO:K01080] [EC:3.1.3.4]
116726320  [KO:K24621]
116726445  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
116726475  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
116726892  [KO:K04715] [EC:2.7.1.138]
116726955  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
116727168  [KO:K00725] [EC:2.4.1.92]
116727521  samd8; sphingomyelin synthase-related protein 1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
116727823  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
116728182  b4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
116728426  acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
116728661  [KO:K12357] [EC:3.2.1.18]
116730302  [KO:K01080] [EC:3.1.3.4]
116730343  [KO:K12382]
116730464  gal3st1; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
116730843  [KO:K24621]
116731929  neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
116732603  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
116733466  arsa; LOW QUALITY PROTEIN: arylsulfatase A [KO:K01134] [EC:3.1.6.8]
116733505  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
116734139  [KO:K04716] [EC:3.1.3.-]
116734200  [KO:K00654] [EC:2.3.1.50]
116735376  [KO:K01080] [EC:3.1.3.4]
116735389  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
116736174  [KO:K04718] [EC:2.7.1.91]
116736184  [KO:K12354] [EC:3.1.4.12]
116736583  cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
116736990  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
116737385  sgpp2; sphingosine-1-phosphate phosphatase 2 isoform X1 [KO:K04717] [EC:3.1.3.-]
116737467  [KO:K12357] [EC:3.2.1.18]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
C23072  Oxidized ceramide
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
xhe00260  Glycine, serine and threonine metabolism
xhe00601  Glycosphingolipid biosynthesis - lacto and neolacto series
xhe00603  Glycosphingolipid biosynthesis - globo and isoglobo series
xhe00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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