KEGG    Network variation - GHRH-GH-IGF signaling
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ENTRYnt06324
NameGHRH-GH-IGF signaling
CategoryPathway view; Endocrine system
DiseaseH02035 Isolated growth hormone deficiency (IGHD)
Display drug-target relation   disease type
   D7
 |		              
N00910    GHRH→GHRHR→GNAS→ADCY→cAMP→PKA→CREB⇒POU1F1⇒(GH1,GH2)
    IGHD4   GHRHR*
    Acromegaly     GNAS*↗
    CPHD1               POU1F1*
 
   D1,D2,D3,D4,D5,D6
 |		      
N00907    GH→GHR→JAK2→STAT5⇒IGF1
    IGHD1 GH*
    Laron syndrome   GHR*
 
   D2
 |		            
N00233    IGF→IGF1R→GRB2→SOS→RAS→RAF→MEK→ERK
    IGF-I deficiency IGF*
    IGF1RES   IGF1R*
 
N01782    GHRL→(GHSR,MRAP2)→(GNA11,GNAQ)
    Genetic obesity GHRL*
    GHDP   GHSR*
    Genetic obesity   MRAP2*

Disease nameDisease category
IGHD4H02035Isolated growth hormone deficiencyEndocrine and metabolic disease
AcromegalyH01483AcromegalyEndocrine and metabolic disease
CPHD1H02036Combined pituitary hormone deficiencyEndocrine and metabolic disease
H00254Growth hormone deficiencyEndocrine and metabolic disease
IGHD1H02035Isolated growth hormone deficiencyEndocrine and metabolic disease
Laron syndromeH02037Laron syndromeEndocrine and metabolic disease
IGF-I deficiencyH02040Insulin-like growth factor I deficiencyEndocrine and metabolic disease
IGF1RESH01274Growth delay due to insulin-like growth factor I resistanceEndocrine and metabolic disease
Genetic obesityH02106Genetic obesityEndocrine and metabolic disease
GHDPH00254Growth hormone deficiencyEndocrine and metabolic disease


Drug name
D1D02691Somatropin (USP/INN)
D2D03297Mecasermin (USAN/INN)
D3D05394Pegvisomant (USAN/INN)
D4D10990Somatrogon (USAN/INN)
D5D11194Somapacitan (USAN/INN)
D6D11486Lonapegsomatropin (USAN/INN)
D7D09015Tesamorelin acetate (USAN)